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Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study

Long-term calorie restriction in humans is not associated with indices of delayed immunologic... BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species. However, in non-obese humans, the effect of CR on the immune system has been understudied relative to its effects on the cardiometabolic system.OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans.METHODS: We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell telomeres compared to gender-, race/ethnicity-, age-, and education-matched “healthy” Body Mass Index (BMI) and “overweight”/“obese” BMI groups.RESULTS: Long-term human CR practitioners had lower BMI (p <  0.001) and fasting glucose (p <  0.001), as expected. They showed similar frequencies of pre-senescent cells (CD8+CD28– T cells and CD57 and PD-1 expressing T cells) to the comparison groups. Even after adjusting for covariates, including cytomegalovirus status, we observed shorter peripheral blood mononuclear cell telomeres in the CR group (p = 0.012) and no difference in granulocyte telomeres between groups (p = 0.42).CONCLUSIONS: We observed no clear evidence that CR as it is currently practiced in humans delays immune aging related to telomere length or T cell immunosenescent markers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition and Healthy Aging IOS Press

Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study

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Publisher
IOS Press
Copyright
Copyright © 2017 IOS Press and the authors. All rights reserved
ISSN
2451-9480
eISSN
2451-9502
DOI
10.3233/NHA-160017
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species. However, in non-obese humans, the effect of CR on the immune system has been understudied relative to its effects on the cardiometabolic system.OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans.METHODS: We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell telomeres compared to gender-, race/ethnicity-, age-, and education-matched “healthy” Body Mass Index (BMI) and “overweight”/“obese” BMI groups.RESULTS: Long-term human CR practitioners had lower BMI (p <  0.001) and fasting glucose (p <  0.001), as expected. They showed similar frequencies of pre-senescent cells (CD8+CD28– T cells and CD57 and PD-1 expressing T cells) to the comparison groups. Even after adjusting for covariates, including cytomegalovirus status, we observed shorter peripheral blood mononuclear cell telomeres in the CR group (p = 0.012) and no difference in granulocyte telomeres between groups (p = 0.42).CONCLUSIONS: We observed no clear evidence that CR as it is currently practiced in humans delays immune aging related to telomere length or T cell immunosenescent markers

Journal

Nutrition and Healthy Aging – IOS Press

Published: Jan 1, 2017

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