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Limited usefulness of antithyroperoxidase and antithyroglobulin assays in Jamaicans with Graves' disease

Limited usefulness of antithyroperoxidase and antithyroglobulin assays in Jamaicans with Graves'... The clinical usefulness of commercially prepared haemagglutination kits for thyroperoxidase (TPO) antibody and thyroglobulin (TG) antibody was evaluated in 145 consecutive Jamaicans with Graves' disease. Sixty two (43%) of the patients were newly diagnosed, 12 (8%) (49%) antibodies. The TPO antibodies were found in 43% antibodies in 12% antibodies. Similar prevalences of TPO antibody were found in newly diagnosed patients and those who had relapsed (44% patients in remission was significantly higher (75%; prevalence of TPO antibody increased significantly with age at onset before age 35 years compared to later onset (56% presence of both TPO antibody (64% antibody (22% ophthalmopathy. Neither of the tests was adequately sensitive in detecting GD in Jamaicans but we recommend testing for TPO antibody without TG antibody as a cost-effective approach. The presence and titres of TPO antibody and TG antibody do not correlate with disease activity and are not reliable enough for monitoring antithyroid drug therapy in GD. There is a need for antibody tests which are efficacious in diagnosing and monitoring antithyroid drug therapy in GD, and suitable for use in diveloping countries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

Limited usefulness of antithyroperoxidase and antithyroglobulin assays in Jamaicans with Graves' disease

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Publisher
IOS Press
Copyright
Copyright © 1999 by IOS Press, Inc
ISSN
1093-2607
eISSN
1875-869X
Publisher site
See Article on Publisher Site

Abstract

The clinical usefulness of commercially prepared haemagglutination kits for thyroperoxidase (TPO) antibody and thyroglobulin (TG) antibody was evaluated in 145 consecutive Jamaicans with Graves' disease. Sixty two (43%) of the patients were newly diagnosed, 12 (8%) (49%) antibodies. The TPO antibodies were found in 43% antibodies in 12% antibodies. Similar prevalences of TPO antibody were found in newly diagnosed patients and those who had relapsed (44% patients in remission was significantly higher (75%; prevalence of TPO antibody increased significantly with age at onset before age 35 years compared to later onset (56% presence of both TPO antibody (64% antibody (22% ophthalmopathy. Neither of the tests was adequately sensitive in detecting GD in Jamaicans but we recommend testing for TPO antibody without TG antibody as a cost-effective approach. The presence and titres of TPO antibody and TG antibody do not correlate with disease activity and are not reliable enough for monitoring antithyroid drug therapy in GD. There is a need for antibody tests which are efficacious in diagnosing and monitoring antithyroid drug therapy in GD, and suitable for use in diveloping countries.

Journal

Human AntibodiesIOS Press

Published: Jan 1, 1999

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