Induction of neutralizing autoantibodies to interferon- \gamma in patients with polyneuropathy
Induction of neutralizing autoantibodies to interferon- \gamma in patients with polyneuropathy
Rihab A. Elkarim ; Maha Mustafa ; Hams Link ; Moiz Bakhiet ; Christina Ekerfelt ; Magnus Vrethem ; Jan Ernerudh
1999-01-01 00:00:00
We previously demonstrated the induction of IFN- \gamma in polyneuropathy patients associated with monoclonal gammopathy, but not in patients with presumably non-immuno-logical types of neuropathy. We herein examined mechanism involving release of neutralizing autoantibodies (Aabs) to IFN- \gamma in sera from those pateints. In contrast to polyneuropathy patients with monoclonal gammopathy, patients with polyneuropathy of presumably non-immunological types showed increased production of neutralizing Aabs specific for IFN- \gamma . These results demonstrate a role for autoimmunity in cytokine regulation. However, their association to the clinical manifestations of the disease requires further investigations, which are necessary for future consideration in therapeutic strategies.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngHuman AntibodiesIOS Presshttp://www.deepdyve.com/lp/ios-press/induction-of-neutralizing-autoantibodies-to-interferon-gamma-in-btwf2zmXHK
Induction of neutralizing autoantibodies to interferon- \gamma in patients with polyneuropathy
We previously demonstrated the induction of IFN- \gamma in polyneuropathy patients associated with monoclonal gammopathy, but not in patients with presumably non-immuno-logical types of neuropathy. We herein examined mechanism involving release of neutralizing autoantibodies (Aabs) to IFN- \gamma in sera from those pateints. In contrast to polyneuropathy patients with monoclonal gammopathy, patients with polyneuropathy of presumably non-immunological types showed increased production of neutralizing Aabs specific for IFN- \gamma . These results demonstrate a role for autoimmunity in cytokine regulation. However, their association to the clinical manifestations of the disease requires further investigations, which are necessary for future consideration in therapeutic strategies.
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