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Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT

Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT BACKGROUND:X-ray CT/micro-CT methods with photon-counting detectors (PCDs) and high Z materials are a hot research topic. One method using PCDs allows for spectral imaging in 5 energy windows while conventional X-ray detectors only collect energy-integrating data.OBJECTIVE:To demonstrate the enhanced separation of contrast materials by using PCDs, multivariate analysis, and linear discriminant methods.METHODS:Phantoms containing iodine and aqueous nanomaterials were scanned on a MARS spectral micro-CT. Image volumes were segmented into separate material-specific populations. Contrast comparisons were made by calculating T2 test statistics in the univariate, pseudo-conventional and multivariate, spectral CT data sets. Separability after Fisher discriminant analysis (FDA) was also assessed.RESULTS:The T2 values calculated for material comparisons increased as a result of the spectral expansion. The majority of the tested contrast agents showed increased T2 values by a factor of ∼2 -3. The total significant T2 statistics in the pure and mixed lanthanide image sets increased in the spectral data set.CONCLUSION:This work consolidates the groundwork for photon-counting-based material decomposition with micro-CT, facilitating future development of novel nanomaterials and their preclinical applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of X-Ray Science and Technology IOS Press

Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT

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References (30)

Publisher
IOS Press
Copyright
Copyright © 2018 © 2018 – IOS Press and the authors. All rights reserved
ISSN
0895-3996
eISSN
1095-9114
DOI
10.3233/XST-18382
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND:X-ray CT/micro-CT methods with photon-counting detectors (PCDs) and high Z materials are a hot research topic. One method using PCDs allows for spectral imaging in 5 energy windows while conventional X-ray detectors only collect energy-integrating data.OBJECTIVE:To demonstrate the enhanced separation of contrast materials by using PCDs, multivariate analysis, and linear discriminant methods.METHODS:Phantoms containing iodine and aqueous nanomaterials were scanned on a MARS spectral micro-CT. Image volumes were segmented into separate material-specific populations. Contrast comparisons were made by calculating T2 test statistics in the univariate, pseudo-conventional and multivariate, spectral CT data sets. Separability after Fisher discriminant analysis (FDA) was also assessed.RESULTS:The T2 values calculated for material comparisons increased as a result of the spectral expansion. The majority of the tested contrast agents showed increased T2 values by a factor of ∼2 -3. The total significant T2 statistics in the pure and mixed lanthanide image sets increased in the spectral data set.CONCLUSION:This work consolidates the groundwork for photon-counting-based material decomposition with micro-CT, facilitating future development of novel nanomaterials and their preclinical applications.

Journal

Journal of X-Ray Science and TechnologyIOS Press

Published: Jan 1, 2018

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