Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/ios-press/emerging-roles-for-histone-deacetylases-in-age-related-muscle-atrophy-BNSkyCHcmD
References (338)
-
( Dupré-Aucouturier S , Castells J , Freyssenet D , Desplanches D . Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. Journal of Applied Physiology. 2015:jap.01031.2014.)
Dupré-Aucouturier S , Castells J , Freyssenet D , Desplanches D . Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. Journal of Applied Physiology. 2015:jap.01031.2014., Dupré-Aucouturier S , Castells J , Freyssenet D , Desplanches D . Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. Journal of Applied Physiology. 2015:jap.01031.2014.
-
( Goodpaster B , Park S , Harris T , Kritchevsky S , Nevitt M , Schwartz A , et al The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006;6110:1059–64.)
Goodpaster B , Park S , Harris T , Kritchevsky S , Nevitt M , Schwartz A , et al The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006;6110:1059–64., Goodpaster B , Park S , Harris T , Kritchevsky S , Nevitt M , Schwartz A , et al The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2006;6110:1059–64.
-
K. Pasanen, J. Parkkari, M. Pasanen, H. Hiilloskorpi, Tanja Mäkinen, M. Järvinen, Pekka Kannus (2008)
Neuromuscular training and the risk of leg injuries in female floorball players: cluster randomised controlled studyBMJ : British Medical Journal, 337
-
( Campbell MJ , McComas AJ , Petito F . Physiological changes in ageing muscles. Journal of Neurology, Neurosurgery, and Psychiatry. 1973;362:174–82.)
Campbell MJ , McComas AJ , Petito F . Physiological changes in ageing muscles. Journal of Neurology, Neurosurgery, and Psychiatry. 1973;362:174–82., Campbell MJ , McComas AJ , Petito F . Physiological changes in ageing muscles. Journal of Neurology, Neurosurgery, and Psychiatry. 1973;362:174–82.
-
D. Bouchard, M. Héroux, I. Janssen (2011)
Association Between Muscle Mass, Leg Strength, and Fat Mass With Physical Function in Older Adults: Influence of Age and SexJournal of Aging and Health, 23
-
D. Attaix, L. Mosoni, D. Dardevet, L. Combaret, P. Mirand, J. Grizard (2005)
Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods.The international journal of biochemistry & cell biology, 37 10
-
( Gerhart-Hines Z , Rodgers J , Bare O , Lerin C , Kim S-H , Mostoslavsky R , et al Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. The EMBO Journal. 2007;267:1913–23.17347648)
Gerhart-Hines Z , Rodgers J , Bare O , Lerin C , Kim S-H , Mostoslavsky R , et al Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. The EMBO Journal. 2007;267:1913–23.17347648, Gerhart-Hines Z , Rodgers J , Bare O , Lerin C , Kim S-H , Mostoslavsky R , et al Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. The EMBO Journal. 2007;267:1913–23.17347648
-
( Smith R , Lin B . Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Current Opinion in Supportive and Palliative Care. 2013;74:352–60.24157714)
Smith R , Lin B . Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Current Opinion in Supportive and Palliative Care. 2013;74:352–60.24157714, Smith R , Lin B . Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Current Opinion in Supportive and Palliative Care. 2013;74:352–60.24157714
-
( Hwee D , Baehr L , Philp A , Baar K , Bodine S . Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age. Aging Cell. 2014;131:92–101.23941502)
Hwee D , Baehr L , Philp A , Baar K , Bodine S . Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age. Aging Cell. 2014;131:92–101.23941502, Hwee D , Baehr L , Philp A , Baar K , Bodine S . Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age. Aging Cell. 2014;131:92–101.23941502
-
A. Trendelenburg, Angelika Meyer, C. Jacobi, J. Feige, D. Glass (2012)
TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin ASkeletal Muscle, 2
-
( Marcell T . Review article: Sarcopenia: Causes, consequences, and preventions. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2003;5810:M911–M6.)
Marcell T . Review article: Sarcopenia: Causes, consequences, and preventions. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2003;5810:M911–M6., Marcell T . Review article: Sarcopenia: Causes, consequences, and preventions. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2003;5810:M911–M6.
-
( Gillick MR . Long-term care options for the frail elderly. Journal of the American Geriatrics Society. 1989;3712:1198–203.2512338)
Gillick MR . Long-term care options for the frail elderly. Journal of the American Geriatrics Society. 1989;3712:1198–203.2512338, Gillick MR . Long-term care options for the frail elderly. Journal of the American Geriatrics Society. 1989;3712:1198–203.2512338
-
Adam Beharry, Pooja Sandesara, B. Roberts, L. Ferreira, Sarah Senf, A. Judge (2014)
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophyJournal of Cell Science, 127
-
B. Goodpaster, S. Park, T. Harris, S. Kritchevsky, M. Nevitt, A. Schwartz, E. Simonsick, F. Tylavsky, M. Visser, A. Newman (2006)
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.The journals of gerontology. Series A, Biological sciences and medical sciences, 61 10
-
( Zhai G , Stankovich J , Ding C , Scott F , Cicuttini F , Jones G . The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: A sibpair study. Arthritis and Rheumatism. 2004;503:805–10.15022322)
Zhai G , Stankovich J , Ding C , Scott F , Cicuttini F , Jones G . The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: A sibpair study. Arthritis and Rheumatism. 2004;503:805–10.15022322, Zhai G , Stankovich J , Ding C , Scott F , Cicuttini F , Jones G . The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: A sibpair study. Arthritis and Rheumatism. 2004;503:805–10.15022322
-
Ruiz (2008)
Association between muscular strength and mortality in men: Prospective cohort studyBMJ
-
( Fling B , Knight C , Kamen G . Relationships between motor unit size and recruitment threshold in older adults: Implications for size principle. Experimental Brain Research. 2009;1972:125–33.19565231)
Fling B , Knight C , Kamen G . Relationships between motor unit size and recruitment threshold in older adults: Implications for size principle. Experimental Brain Research. 2009;1972:125–33.19565231, Fling B , Knight C , Kamen G . Relationships between motor unit size and recruitment threshold in older adults: Implications for size principle. Experimental Brain Research. 2009;1972:125–33.19565231
-
Audrey Wang, M. Kruhlak, Jiong Wu, N. Bertos, Marko Vezmar, B. Posner, D. Bazett-Jones, Xiang-Jiao Yang (2000)
Regulation of Histone Deacetylase 4 by Binding of 14-3-3 ProteinsMolecular and Cellular Biology, 20
-
V. Moresi, M. Carrer, Chad Grueter, O. Rifki, J. Shelton, J. Richardson, R. Bassel-Duby, E. Olson (2012)
Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in miceProceedings of the National Academy of Sciences, 109
-
( Visser M , Deeg D , Lips P . Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. The Journal of Clinical Endocrinology and Metabolism. 2003;8812:5766–72.14671166)
Visser M , Deeg D , Lips P . Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. The Journal of Clinical Endocrinology and Metabolism. 2003;8812:5766–72.14671166, Visser M , Deeg D , Lips P . Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. The Journal of Clinical Endocrinology and Metabolism. 2003;8812:5766–72.14671166
-
( McKinsey T , Zhang C-L , Lu J , Olson E . Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;4086808:106–11.11081517)
McKinsey T , Zhang C-L , Lu J , Olson E . Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;4086808:106–11.11081517, McKinsey T , Zhang C-L , Lu J , Olson E . Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;4086808:106–11.11081517
-
C. Winbanks, Bo Wang, C. Beyer, Phillip Koh, L. White, P. Kantharidis, P. Gregorevic (2011)
TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4The Journal of Biological Chemistry, 286
-
( Sartorelli V , Puri PL , Hamamori Y , Ogryzko V , Chung G , Nakatani Y , et al Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Molecular Cell. 1999;45:725–34.10619020)
Sartorelli V , Puri PL , Hamamori Y , Ogryzko V , Chung G , Nakatani Y , et al Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Molecular Cell. 1999;45:725–34.10619020, Sartorelli V , Puri PL , Hamamori Y , Ogryzko V , Chung G , Nakatani Y , et al Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Molecular Cell. 1999;45:725–34.10619020
-
Alice Lebreton, G. Lakisic, L. Fritsch, T. Tham, Ana Camejo, Pierre‐Jean Matteï, B. Regnault, M. Nahori, D. Cabanes, A. Gautreau, A. Dessen, P. Cossart, H. Bierne (2011)
A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid MetabolismScience, 331
-
T. Phillips, C. Leeuwenburgh (2005)
Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restrictionThe FASEB Journal, 19
-
Michael Walsh, A. Bhattacharya, K. Sataranatarajan, R. Qaisar, L. Sloane, M. Rahman, M. Kinter, H. Remmen (2015)
The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during agingAging Cell, 14
-
Michael Walsh, A. Bhattacharya, Yuhong Liu, H. Remmen (2015)
Butyrate prevents muscle atrophy after sciatic nerve crushMuscle & Nerve, 52
-
Victoria Siriett, M. Salerno, C. Berry, G. Nicholas, Rob Bower, R. Kambadur, Mridula Sharma (2007)
Antagonism of myostatin enhances muscle regeneration during sarcopenia.Molecular therapy : the journal of the American Society of Gene Therapy, 15 8
-
( Christensen D , Dahllöf M , Lundh M , Rasmussen D , Nielsen M , Billestrup N , et al Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Molecular Medicine (Cambridge, Mass). 2011;175-6:378–90.)
Christensen D , Dahllöf M , Lundh M , Rasmussen D , Nielsen M , Billestrup N , et al Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Molecular Medicine (Cambridge, Mass). 2011;175-6:378–90., Christensen D , Dahllöf M , Lundh M , Rasmussen D , Nielsen M , Billestrup N , et al Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Molecular Medicine (Cambridge, Mass). 2011;175-6:378–90.
-
Asoke Mal, Michael Sturniolo, R. Schiltz, Mrinal Ghosh, M. Harter (2001)
A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic programThe EMBO Journal, 20
-
Katherine Bricceno, P. Sampognaro, James Meerbeke, C. Sumner, K. Fischbeck, Barrington Burnett (2012)
Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice.Human molecular genetics, 21 20
-
( Fulco M , Schiltz L , Iezzi S , King T , Zhao P , Kashiwaya Y , et al Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Molecular Cell. 2003;121:51–62.12887892)
Fulco M , Schiltz L , Iezzi S , King T , Zhao P , Kashiwaya Y , et al Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Molecular Cell. 2003;121:51–62.12887892, Fulco M , Schiltz L , Iezzi S , King T , Zhao P , Kashiwaya Y , et al Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Molecular Cell. 2003;121:51–62.12887892
-
R. Rudolf, M. Khan, S. Labeit, M. Deschenes (2014)
Degeneration of Neuromuscular Junction in Age and DystrophyFrontiers in Aging Neuroscience, 6
-
M. Sandri, L. Barberi, A. Bijlsma, A. Bijlsma, B. Blaauw, K. Dyar, G. Milan, C. Mammucari, C. Meskers, G. Pallafacchina, A. Paoli, D. Pion, M. Roceri, V. Romanello, A. Serrano, L. Toniolo, L. Larsson, L. Larsson, A. Maier, P. Muñoz-Cánoves, A. Musarò, M. Pende, C. Reggiani, R. Rizzuto, S. Schiaffino (2013)
Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathwayBiogerontology, 14
-
( D’Andrea M , Pisaniello A , Serra C , Senni MI , Castaldi L , Molinaro M , et al Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. Journal of Cellular Physiology. 2006;2072:379–88.16419034)
D’Andrea M , Pisaniello A , Serra C , Senni MI , Castaldi L , Molinaro M , et al Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. Journal of Cellular Physiology. 2006;2072:379–88.16419034, D’Andrea M , Pisaniello A , Serra C , Senni MI , Castaldi L , Molinaro M , et al Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. Journal of Cellular Physiology. 2006;2072:379–88.16419034
-
Z. Erim, M. Beg, David Burke, C. Luca (1999)
Effects of aging on motor-unit control properties.Journal of neurophysiology, 82 5
-
( Lundby A , Lage K , Weinert B , Bekker-Jensen D , Secher A , Skovgaard T , et al Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports. 2012;22:419–31.22902405)
Lundby A , Lage K , Weinert B , Bekker-Jensen D , Secher A , Skovgaard T , et al Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports. 2012;22:419–31.22902405, Lundby A , Lage K , Weinert B , Bekker-Jensen D , Secher A , Skovgaard T , et al Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Reports. 2012;22:419–31.22902405
-
( Pardo P , Boriek A . The physiological roles of Sirt1 in skeletal muscle. Aging. 2011;34:430–7.21483036)
Pardo P , Boriek A . The physiological roles of Sirt1 in skeletal muscle. Aging. 2011;34:430–7.21483036, Pardo P , Boriek A . The physiological roles of Sirt1 in skeletal muscle. Aging. 2011;34:430–7.21483036
-
( Yousef H , Conboy M , Morgenthaler A , Schlesinger C , Bugaj L , Paliwal P , et al Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 2015;614:11959–78.26003168)
Yousef H , Conboy M , Morgenthaler A , Schlesinger C , Bugaj L , Paliwal P , et al Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 2015;614:11959–78.26003168, Yousef H , Conboy M , Morgenthaler A , Schlesinger C , Bugaj L , Paliwal P , et al Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 2015;614:11959–78.26003168
-
P. Pardo, A. Boriek (2011)
The physiological roles of Sirt1 in skeletal muscleAging (Albany NY), 3
-
M. Vinciguerra, M. Fulco, A. Ladurner, V. Sartorelli, N. Rosenthal (2010)
SirT1 in muscle physiology and disease: lessons from mouse modelsDisease Models & Mechanisms, 3
-
( Marzetti E , Lawler J , Hiona A , Manini T , Seo A , Leeuwenburgh C . Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radical Biology and Medicine. 2008;442:160–8.18191752)
Marzetti E , Lawler J , Hiona A , Manini T , Seo A , Leeuwenburgh C . Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radical Biology and Medicine. 2008;442:160–8.18191752, Marzetti E , Lawler J , Hiona A , Manini T , Seo A , Leeuwenburgh C . Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radical Biology and Medicine. 2008;442:160–8.18191752
-
Hyung‐Lyun Kang, S. Benzer, K. Min (2002)
Life extension in Drosophila by feeding a drugProceedings of the National Academy of Sciences of the United States of America, 99
-
T. McKinsey, Chun-li Zhang, Jian-rong Lu, E. Olson (2000)
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiationNature, 408
-
( Miska EA , Karlsson C , Langley E , Nielsen SJ , Pines J , Kouzarides T . HDAC4 deacetylase associates with and represses the MEF2 transcription factor. The EMBO Journal. 1999;1818:5099–107.10487761)
Miska EA , Karlsson C , Langley E , Nielsen SJ , Pines J , Kouzarides T . HDAC4 deacetylase associates with and represses the MEF2 transcription factor. The EMBO Journal. 1999;1818:5099–107.10487761, Miska EA , Karlsson C , Langley E , Nielsen SJ , Pines J , Kouzarides T . HDAC4 deacetylase associates with and represses the MEF2 transcription factor. The EMBO Journal. 1999;1818:5099–107.10487761
-
( Reed T , Fabsitz RR , Selby JV , Carmelli D . Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Annals of Human Biology. 1991;185:425–32.1952800)
Reed T , Fabsitz RR , Selby JV , Carmelli D . Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Annals of Human Biology. 1991;185:425–32.1952800, Reed T , Fabsitz RR , Selby JV , Carmelli D . Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Annals of Human Biology. 1991;185:425–32.1952800
-
( McBrian M , Behbahan IS , Ferrari R , Su T , Huang T-W , Li K , et al Histone acetylation regulates intracellular pH. Molecular Cell. 2013;492:310–21.23201122)
McBrian M , Behbahan IS , Ferrari R , Su T , Huang T-W , Li K , et al Histone acetylation regulates intracellular pH. Molecular Cell. 2013;492:310–21.23201122, McBrian M , Behbahan IS , Ferrari R , Su T , Huang T-W , Li K , et al Histone acetylation regulates intracellular pH. Molecular Cell. 2013;492:310–21.23201122
-
R. Bassel-Duby, E. Olson (2006)
Signaling pathways in skeletal muscle remodeling.Annual review of biochemistry, 75
-
( Liu N , Williams A , Maxeiner J , Bezprozvannaya S , Shelton J , Richardson J , et al microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. Journal of Clinical Investigation. 2012;1226:2054–65.22546853)
Liu N , Williams A , Maxeiner J , Bezprozvannaya S , Shelton J , Richardson J , et al microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. Journal of Clinical Investigation. 2012;1226:2054–65.22546853, Liu N , Williams A , Maxeiner J , Bezprozvannaya S , Shelton J , Richardson J , et al microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. Journal of Clinical Investigation. 2012;1226:2054–65.22546853
-
Jian-rong Lu, T. McKinsey, Chun-li Zhang, E. Olson (2000)
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.Molecular cell, 6 2
-
D. Hwee, Leslie Baehr, A. Philp, K. Baar, S. Bodine (2013)
Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with ageAging Cell, 13
-
Dympna Gallagher, Marjolein Visser, R. Meersman, Dennis Sepúlveda, R. Baumgartner, R. Pierson, T. Harris, S. Heymsfield (1997)
Appendicular skeletal muscle mass: effects of age, gender, and ethnicity.Journal of applied physiology, 83 1
-
( Kang H-L , Benzer S , Min K-T . Life extension in Drosophila by feeding a drug. Proceedings of the National Academy of Sciences of the United States of America. 2002;992:838–43.11792861)
Kang H-L , Benzer S , Min K-T . Life extension in Drosophila by feeding a drug. Proceedings of the National Academy of Sciences of the United States of America. 2002;992:838–43.11792861, Kang H-L , Benzer S , Min K-T . Life extension in Drosophila by feeding a drug. Proceedings of the National Academy of Sciences of the United States of America. 2002;992:838–43.11792861
-
Pedro Sousa‐Victor, Susana Gutarra, Laura Garcia-Prat, J. Rodríguez-Ubreva, L. Ortet, Vanessa Ruiz-Bonilla, M. Jardí, E. Ballestar, S. González, A. Serrano, Eusebio Perdiguero, P. Muñoz-Cánoves (2014)
Geriatric muscle stem cells switch reversible quiescence into senescenceNature, 506
-
( Fry C , Lee J , Mula J , Kirby T , Jackson J , Liu F , et al Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015;211:76–80.25501907)
Fry C , Lee J , Mula J , Kirby T , Jackson J , Liu F , et al Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015;211:76–80.25501907, Fry C , Lee J , Mula J , Kirby T , Jackson J , Liu F , et al Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015;211:76–80.25501907
-
G. Zhai, J. Stankovich, C. Ding, F. Scott, F. Cicuttini, G. Jones (2004)
The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study.Arthritis and rheumatism, 50 3
-
M. Cree, B. Newcomer, C. Katsanos, M. Sheffield-Moore, D. Chinkes, A. Aarsland, R. Urban, R. Wolfe (2004)
Intramuscular and liver triglycerides are increased in the elderly.The Journal of clinical endocrinology and metabolism, 89 8
-
P. Balagopal, O. Rooyackers, D. Adey, P. Ades, K. Nair (1997)
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans.American journal of physiology. Endocrinology and metabolism, 273 4
-
V. Sartorelli, P. Puri, P. Puri, Y. Hamamori, V. Ogryzko, Gene Chung, Y. Nakatani, Jean Wang, L. Kedes (1999)
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.Molecular cell, 4 5
-
( Burton L , Sumukadas D . Optimal management of sarcopenia. Clinical Interventions in Aging. 2010;5, 217–28.20852669)
Burton L , Sumukadas D . Optimal management of sarcopenia. Clinical Interventions in Aging. 2010;5, 217–28.20852669, Burton L , Sumukadas D . Optimal management of sarcopenia. Clinical Interventions in Aging. 2010;5, 217–28.20852669
-
S. Consalvi, C. Mozzetta, P. Bettica, M. Germani, F. Fiorentini, F. Bene, M. Rocchetti, F. Leoni, V. Monzani, P. Mascagni, P. Puri, V. Saccone (2013)
Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor GivinostatMolecular Medicine, 19
-
( Faulkner J , Larkin L , Claflin D , Brooks S . Age-related changes in the structure and function of skeletal muscles. Clinical and Experimental Pharmacology & Physiology. 2007;3411:1091–6.17880359)
Faulkner J , Larkin L , Claflin D , Brooks S . Age-related changes in the structure and function of skeletal muscles. Clinical and Experimental Pharmacology & Physiology. 2007;3411:1091–6.17880359, Faulkner J , Larkin L , Claflin D , Brooks S . Age-related changes in the structure and function of skeletal muscles. Clinical and Experimental Pharmacology & Physiology. 2007;3411:1091–6.17880359
-
S. Carnio, Francesca LoVerso, M. Baraibar, E. Longa, M. Khan, M. Maffei, M. Reischl, M. Canepari, S. Loefler, H. Kern, B. Blaauw, B. Friguet, R. Bottinelli, R. Rudolf, M. Sandri (2014)
Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious AgingCell Reports, 8
-
( Chen L , Nelson D , Zhao Y , Cui Z , Johnston J . Relationship between muscle mass and muscle strength, and the impact of comorbidities: A population-based, cross-sectional study of older adults in the United States. BMC Geriatrics. 2013;131:74.23865675)
Chen L , Nelson D , Zhao Y , Cui Z , Johnston J . Relationship between muscle mass and muscle strength, and the impact of comorbidities: A population-based, cross-sectional study of older adults in the United States. BMC Geriatrics. 2013;131:74.23865675, Chen L , Nelson D , Zhao Y , Cui Z , Johnston J . Relationship between muscle mass and muscle strength, and the impact of comorbidities: A population-based, cross-sectional study of older adults in the United States. BMC Geriatrics. 2013;131:74.23865675
-
Kewei Ma, J. Chan, G. Zhu, Zhenguo Wu (2005)
Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcriptional Activity, and Myogenic DifferentiationMolecular and Cellular Biology, 25
-
K. Opalach, S. Rangaraju, Irina Madorsky, C. Leeuwenburgh, L. Notterpek (2010)
Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves.Rejuvenation research, 13 1
-
( Verdijk L , Gleeson B , Jonkers R , Meijer K , Savelberg H , Dendale P , et al Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type–specific increase in satellite cell content in elderly men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2009;64A3:332–9.)
Verdijk L , Gleeson B , Jonkers R , Meijer K , Savelberg H , Dendale P , et al Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type–specific increase in satellite cell content in elderly men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2009;64A3:332–9., Verdijk L , Gleeson B , Jonkers R , Meijer K , Savelberg H , Dendale P , et al Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type–specific increase in satellite cell content in elderly men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2009;64A3:332–9.
-
( Velloso CP . Regulation of muscle mass by growth hormone and IGF-I. British Journal of Pharmacology. 2008;1543:557–68.18500379)
Velloso CP . Regulation of muscle mass by growth hormone and IGF-I. British Journal of Pharmacology. 2008;1543:557–68.18500379, Velloso CP . Regulation of muscle mass by growth hormone and IGF-I. British Journal of Pharmacology. 2008;1543:557–68.18500379
-
( Erim Z , Beg F , Burke D , de Luca C . Effects of Aging on Motor-Unit Control Properties. Journal of Neurophysiology. 1999;825:2081–91.10561389)
Erim Z , Beg F , Burke D , de Luca C . Effects of Aging on Motor-Unit Control Properties. Journal of Neurophysiology. 1999;825:2081–91.10561389, Erim Z , Beg F , Burke D , de Luca C . Effects of Aging on Motor-Unit Control Properties. Journal of Neurophysiology. 1999;825:2081–91.10561389
-
( Lanza I , Zabielski P , Klaus K , Morse D , Heppelmann C , Bergen R , et al Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metabolism. 2012;166:777–88.23217257)
Lanza I , Zabielski P , Klaus K , Morse D , Heppelmann C , Bergen R , et al Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metabolism. 2012;166:777–88.23217257, Lanza I , Zabielski P , Klaus K , Morse D , Heppelmann C , Bergen R , et al Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metabolism. 2012;166:777–88.23217257
-
( Sinha M , Jang Y , Oh J , Khong D , Wu E , Manohar R , et al Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014;3446184:649–52.24797481)
Sinha M , Jang Y , Oh J , Khong D , Wu E , Manohar R , et al Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014;3446184:649–52.24797481, Sinha M , Jang Y , Oh J , Khong D , Wu E , Manohar R , et al Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014;3446184:649–52.24797481
-
( Gomes A , Price N , Ling A , Moslehi J , Montgomery M , Rajman L , et al Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;1557:1624–38.24360282)
Gomes A , Price N , Ling A , Moslehi J , Montgomery M , Rajman L , et al Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;1557:1624–38.24360282, Gomes A , Price N , Ling A , Moslehi J , Montgomery M , Rajman L , et al Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;1557:1624–38.24360282
-
( Pietrangelo T , Puglielli C , Mancinelli R , Beccafico S , Fanò G , Fulle S . Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology. 2009;448:523–31.19457451)
Pietrangelo T , Puglielli C , Mancinelli R , Beccafico S , Fanò G , Fulle S . Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology. 2009;448:523–31.19457451, Pietrangelo T , Puglielli C , Mancinelli R , Beccafico S , Fanò G , Fulle S . Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology. 2009;448:523–31.19457451
-
( Charette SL , McEvoy L , Pyka G , Snow-Harter C , Guido D , Wiswell RA , et al Muscle hypertrophy response to resistance training in older women. Journal of Applied Physiology (Bethesda, Md: 1985). 1991;705:1912–6.)
Charette SL , McEvoy L , Pyka G , Snow-Harter C , Guido D , Wiswell RA , et al Muscle hypertrophy response to resistance training in older women. Journal of Applied Physiology (Bethesda, Md: 1985). 1991;705:1912–6., Charette SL , McEvoy L , Pyka G , Snow-Harter C , Guido D , Wiswell RA , et al Muscle hypertrophy response to resistance training in older women. Journal of Applied Physiology (Bethesda, Md: 1985). 1991;705:1912–6.
-
( Heredia J , Mukundan L , Chen F , Mueller A , Deo R , Locksley R , et al Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013;1532:376–88.23582327)
Heredia J , Mukundan L , Chen F , Mueller A , Deo R , Locksley R , et al Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013;1532:376–88.23582327, Heredia J , Mukundan L , Chen F , Mueller A , Deo R , Locksley R , et al Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013;1532:376–88.23582327
-
T. Chatterjee, Joshua Basford, Kan Yiew, D. Stepp, D. Hui, N. Weintraub (2014)
Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic diseaseAdipocyte, 3
-
Diem-Hang Nguyen-Tran, N. Hait, Henrik Sperber, Junlin Qi, Karin Fischer, N. Ieronimakis, M. Pantoja, Aislinn Hays, J. Allegood, M. Reyes, S. Spiegel, H. Ruohola-Baker (2013)
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophyDisease Models & Mechanisms, 7
-
E. Merritt, Michael Stec, A. Thalacker-Mercer, S. Windham, J. Cross, David Shelley, S. Tuggle, David Kosek, Jeong-Su Kim, M. Bamman (2013)
Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans.Journal of applied physiology, 115 6
-
J. Backs, Thea Backs, S. Bezprozvannaya, T. McKinsey, E. Olson (2008)
Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4Molecular and Cellular Biology, 28
-
( Ebert S , Dyle M , Bullard S , Dierdorff J , Murry D , Fox D , et al Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy. The Journal of Biological Chemistry. 2015;29042:25497–511.26338703)
Ebert S , Dyle M , Bullard S , Dierdorff J , Murry D , Fox D , et al Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy. The Journal of Biological Chemistry. 2015;29042:25497–511.26338703, Ebert S , Dyle M , Bullard S , Dierdorff J , Murry D , Fox D , et al Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy. The Journal of Biological Chemistry. 2015;29042:25497–511.26338703
-
( Egerman M , Cadena S , Gilbert J , Meyer A , Nelson H , Swalley S , et al GDF11 increases with age and inhibits skeletal muscle regeneration. Cell Metabolism. 2015;221:164–74.26001423)
Egerman M , Cadena S , Gilbert J , Meyer A , Nelson H , Swalley S , et al GDF11 increases with age and inhibits skeletal muscle regeneration. Cell Metabolism. 2015;221:164–74.26001423, Egerman M , Cadena S , Gilbert J , Meyer A , Nelson H , Swalley S , et al GDF11 increases with age and inhibits skeletal muscle regeneration. Cell Metabolism. 2015;221:164–74.26001423
-
( Joe A , Yi L , Natarajan A , Le Grand F , So L , Wang J , et al Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nature Cell Biology. 2010;122:153–63.20081841)
Joe A , Yi L , Natarajan A , Le Grand F , So L , Wang J , et al Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nature Cell Biology. 2010;122:153–63.20081841, Joe A , Yi L , Natarajan A , Le Grand F , So L , Wang J , et al Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nature Cell Biology. 2010;122:153–63.20081841
-
( Mozzetta C , Consalvi S , Saccone V , Tierney M , Diamantini A , Mitchell K , et al Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Molecular Medicine. 2013;54:626–39.23505062)
Mozzetta C , Consalvi S , Saccone V , Tierney M , Diamantini A , Mitchell K , et al Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Molecular Medicine. 2013;54:626–39.23505062, Mozzetta C , Consalvi S , Saccone V , Tierney M , Diamantini A , Mitchell K , et al Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Molecular Medicine. 2013;54:626–39.23505062
-
R. Chai, J. Vukovic, S. Dunlop, M. Grounds, T. Shavlakadze (2011)
Striking Denervation of Neuromuscular Junctions without Lumbar Motoneuron Loss in Geriatric Mouse MusclePLoS ONE, 6
-
C. Velloso (2008)
Regulation of muscle mass by growth hormone and IGF‐IBritish Journal of Pharmacology, 154
-
Rosamund Smith, B. Lin (2013)
Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disordersCurrent Opinion in Supportive and Palliative Care, 7
-
T. Pietrangelo, C. Puglielli, R. Mancinelli, S. Beccafico, G. Fanó, S. Fulle (2009)
Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiationExperimental Gerontology, 44
-
A. Husom, E. Peters, Erin Kolling, N. Fugere, L. Thompson, D. Ferrington (2004)
Altered proteasome function and subunit composition in aged muscle.Archives of biochemistry and biophysics, 421 1
-
( Sandri M , Barberi L , Bijlsma AY , Blaauw B , Dyar KA , Milan G , et al Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology. 2013;143:303–23.23686362)
Sandri M , Barberi L , Bijlsma AY , Blaauw B , Dyar KA , Milan G , et al Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology. 2013;143:303–23.23686362, Sandri M , Barberi L , Bijlsma AY , Blaauw B , Dyar KA , Milan G , et al Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology. 2013;143:303–23.23686362
-
( Siriett V , Salerno MS , Berry C , Nicholas G , Bower R , Kambadur R , et al Antagonism of myostatin enhances muscle regeneration during sarcopenia. Molecular Therapy: The Journal of the American Society of Gene Therapy. 2007;158:1463–70.17551508)
Siriett V , Salerno MS , Berry C , Nicholas G , Bower R , Kambadur R , et al Antagonism of myostatin enhances muscle regeneration during sarcopenia. Molecular Therapy: The Journal of the American Society of Gene Therapy. 2007;158:1463–70.17551508, Siriett V , Salerno MS , Berry C , Nicholas G , Bower R , Kambadur R , et al Antagonism of myostatin enhances muscle regeneration during sarcopenia. Molecular Therapy: The Journal of the American Society of Gene Therapy. 2007;158:1463–70.17551508
-
R. Maughan, J. Watson, J. Weir (1983)
Strength and cross‐sectional area of human skeletal muscle.The Journal of Physiology, 338
-
Ning Liu, Andrew Williams, Johanna Maxeiner, S. Bezprozvannaya, J. Shelton, J. Richardson, R. Bassel-Duby, E. Olson (2012)
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.The Journal of clinical investigation, 122 6
-
A. Lundby, K. Lage, B. Weinert, Dorte Bekker-Jensen, A. Secher, T. Skovgaard, C. Kelstrup, Anatoliy Dmytriyev, Chunaram Choudhary, C. Lundby, J. Olsen (2012)
Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular PatternsCell reports, 2
-
M. Mihaylova, Debbie Vasquez, Kim Ravnskjaer, Pierre-Damien Denechaud, R. Yu, J. Alvarez, M. Downes, R. Evans, M. Montminy, R. Shaw (2011)
Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose HomeostasisCell, 145
-
( Chargé S , Brack A , Hughes S . Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy. American Journal of Physiology Cell Physiology. 2002);2834.)
Chargé S , Brack A , Hughes S . Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy. American Journal of Physiology Cell Physiology. 2002);2834., Chargé S , Brack A , Hughes S . Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy. American Journal of Physiology Cell Physiology. 2002);2834.
-
( Conboy I , Conboy M , Wagers A , Girma E , Weissman I , Rando T . Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;4337027:760–4.15716955)
Conboy I , Conboy M , Wagers A , Girma E , Weissman I , Rando T . Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;4337027:760–4.15716955, Conboy I , Conboy M , Wagers A , Girma E , Weissman I , Rando T . Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;4337027:760–4.15716955
-
T. Wenz, S. Rossi, R. Rotundo, B. Spiegelman, C. Moraes (2009)
Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during agingProceedings of the National Academy of Sciences, 106
-
I. Conboy, M. Conboy, A. Wagers, Eric Girma, I. Weissman, T. Rando (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentNature, 433
-
( Hepple R , Qin M , Nakamoto H , Goto S . Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: Implications for sarcopenia. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2008);2954.)
Hepple R , Qin M , Nakamoto H , Goto S . Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: Implications for sarcopenia. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2008);2954., Hepple R , Qin M , Nakamoto H , Goto S . Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: Implications for sarcopenia. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2008);2954.
-
( Wenz T , Rossi S , Rotundo R , Spiegelman B , Moraes C . Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences. 2009;10648:20405–10.)
Wenz T , Rossi S , Rotundo R , Spiegelman B , Moraes C . Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences. 2009;10648:20405–10., Wenz T , Rossi S , Rotundo R , Spiegelman B , Moraes C . Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences. 2009;10648:20405–10.
-
M. Tajrishi, Shuichi Sato, Jonghyun Shin, T. Zheng, L. Burkly, Ashok Kumar (2014)
The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle.Biochemical and biophysical research communications, 446 4
-
Louise Burton, D. Sumukadas (2010)
Optimal management of sarcopeniaClinical Interventions in Aging, 5
-
Tadahiro Shimazu, M. Hirschey, John Newman, Wenjuan He, Kotaro Shirakawa, Natacha Moan, Carrie Grueter, H. Lim, L. Saunders, R. Stevens, C. Newgard, Robert Farese, R. Cabo, S. Ulrich, K. Akassoglou, E. Verdin (2013)
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase InhibitorScience, 339
-
G. Shefer, Daniel Mark, Joshua Richardson, Z. Yablonka-Reuveni (2006)
Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle.Developmental biology, 294 1
-
T. Marcell (2003)
Sarcopenia: causes, consequences, and preventions.The journals of gerontology. Series A, Biological sciences and medical sciences, 58 10
-
( Galmozzi A , Mitro N , Ferrari A , Gers E , Gilardi F , Godio C , et al Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes. 2013;623:732–42.23069623)
Galmozzi A , Mitro N , Ferrari A , Gers E , Gilardi F , Godio C , et al Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes. 2013;623:732–42.23069623, Galmozzi A , Mitro N , Ferrari A , Gers E , Gilardi F , Godio C , et al Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes. 2013;623:732–42.23069623
-
M. Sehl, F. Yates (2001)
Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people.The journals of gerontology. Series A, Biological sciences and medical sciences, 56 5
-
( Hughes V , Roubenoff R , Wood M , Frontera W , Evans W , Fiatarone Singh M . Anthropometric assessment of 10-y changes in body composition in the elderly. The American Journal of Clinical Nutrition. 2004;802:475–82.15277173)
Hughes V , Roubenoff R , Wood M , Frontera W , Evans W , Fiatarone Singh M . Anthropometric assessment of 10-y changes in body composition in the elderly. The American Journal of Clinical Nutrition. 2004;802:475–82.15277173, Hughes V , Roubenoff R , Wood M , Frontera W , Evans W , Fiatarone Singh M . Anthropometric assessment of 10-y changes in body composition in the elderly. The American Journal of Clinical Nutrition. 2004;802:475–82.15277173
-
U. Dressel, P. Bailey, S.-C. Wang, M. Downes, R. Evans, G. Muscat (2001)
A Dynamic Role for HDAC7 in MEF2-mediated Muscle Differentiation*The Journal of Biological Chemistry, 276
-
L. Verdijk, Benjamin Gleeson, R. Jonkers, K. Meijer, H. Savelberg, P. Dendale, L. Loon (2009)
Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men.The journals of gerontology. Series A, Biological sciences and medical sciences, 64 3
-
( Walsh M , Bhattacharya A , Sataranatarajan K , Qaisar R , Sloane L , Rahman M , et al The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell. 2015;146:957–70.26290460)
Walsh M , Bhattacharya A , Sataranatarajan K , Qaisar R , Sloane L , Rahman M , et al The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell. 2015;146:957–70.26290460, Walsh M , Bhattacharya A , Sataranatarajan K , Qaisar R , Sloane L , Rahman M , et al The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell. 2015;146:957–70.26290460
-
( Wiswell R , Hawkins S , Jaque V , Hyslop D , Constantino N , Tarpenning K , et al Relationship between physiological loss, performance decrement, and age in master athletes. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2001;5610:M618–M26.)
Wiswell R , Hawkins S , Jaque V , Hyslop D , Constantino N , Tarpenning K , et al Relationship between physiological loss, performance decrement, and age in master athletes. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2001;5610:M618–M26., Wiswell R , Hawkins S , Jaque V , Hyslop D , Constantino N , Tarpenning K , et al Relationship between physiological loss, performance decrement, and age in master athletes. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2001;5610:M618–M26.
-
A. Hinken, Janine Powers, G. Luo, J. Holt, A. Billin, A. Russell (2016)
Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cellsAging Cell, 15
-
B. Léger, Romain Cartoni, M. Praz, S. Lamon, O. Deriaz, Antoinette Crettenand, C. Gobelet, Paul Rohmer, M. Konzelmann, F. Luthi, A. Russell (2006)
Akt signalling through GSK‐3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophyThe Journal of Physiology, 576
-
V. Kadhiresan, C. Hassett, J. Faulkner (1996)
Properties of single motor units in medial gastrocnemius muscles of adult and old rats.The Journal of Physiology, 493
-
( Kadhiresan VA , Hassett CA , Faulkner JA . Properties of single motor units in medial gastrocnemius muscles of adult and old rats. The Journal of Physiology. 1996;493Pt 2:543–52.8782115)
Kadhiresan VA , Hassett CA , Faulkner JA . Properties of single motor units in medial gastrocnemius muscles of adult and old rats. The Journal of Physiology. 1996;493Pt 2:543–52.8782115, Kadhiresan VA , Hassett CA , Faulkner JA . Properties of single motor units in medial gastrocnemius muscles of adult and old rats. The Journal of Physiology. 1996;493Pt 2:543–52.8782115
-
Susan, L. Charette, Lawrence, McEVOY, Gisela, Pyka, Christine, Snow-Harter, David, Guido, Robert, A. Wiswell, Marcus (1992)
Muscle hypertrophy response to resistance training in older women.Journal of applied physiology, 70 5
-
( Huygens W , Thomis MA , Peeters MW , Aerssens J , Vlietinck R , Beunen GP . Quantitative trait loci for human muscle strength: Linkage analysis of myostatin pathway genes. Physiological Genomics. 2005;223:390–7.15914581)
Huygens W , Thomis MA , Peeters MW , Aerssens J , Vlietinck R , Beunen GP . Quantitative trait loci for human muscle strength: Linkage analysis of myostatin pathway genes. Physiological Genomics. 2005;223:390–7.15914581, Huygens W , Thomis MA , Peeters MW , Aerssens J , Vlietinck R , Beunen GP . Quantitative trait loci for human muscle strength: Linkage analysis of myostatin pathway genes. Physiological Genomics. 2005;223:390–7.15914581
-
E. Miska, C. Karlsson, E. Langley, S. Nielsen, J. Pines, T. Kouzarides (1999)
HDAC4 deacetylase associates with and represses the MEF2 transcription factorThe EMBO Journal, 18
-
( Edwards C , Canfield J , Copes N , Rehan M , Lipps D , Bradshaw P . D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 2014;68:621–44.25127866)
Edwards C , Canfield J , Copes N , Rehan M , Lipps D , Bradshaw P . D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 2014;68:621–44.25127866, Edwards C , Canfield J , Copes N , Rehan M , Lipps D , Bradshaw P . D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 2014;68:621–44.25127866
-
( Cohen T , Waddell D , Barrientos T , Lu Z , Feng G , Cox G , et al The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. The Journal of Biological Chemistry. 2007;28246:33752–9.17873280)
Cohen T , Waddell D , Barrientos T , Lu Z , Feng G , Cox G , et al The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. The Journal of Biological Chemistry. 2007;28246:33752–9.17873280, Cohen T , Waddell D , Barrientos T , Lu Z , Feng G , Cox G , et al The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. The Journal of Biological Chemistry. 2007;28246:33752–9.17873280
-
Makoto Minamiyama, M. Katsuno, H. Adachi, M. Waza, Chen Sang, Yasushi Kobayashi, F. Tanaka, M. Doyu, A. Inukai, G. Sobue (2004)
Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.Human molecular genetics, 13 11
-
B. Cosgrove, P. Gilbert, E. Porpiglia, F. Mourkioti, Steven Lee, S. Corbel, Michael Llewellyn, S. Delp, H. Blau (2014)
Rejuvenation of the aged muscle stem cell population restores strength to injured aged musclesNature medicine, 20
-
M. Gillick (1989)
Long‐Term Care Options for the Frail ElderlyJournal of the American Geriatrics Society, 37
-
J. Karlsson, P. Komi, J. Viitasalo (1979)
Muscle strength and muscle characteristics in monozygous and dizygous twins.Acta physiologica Scandinavica, 106 3
-
( Gregoretti I , Lee Y-M , Goodson H . Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis. Journal of Molecular Biology. 2004;3381:17–31.15050820)
Gregoretti I , Lee Y-M , Goodson H . Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis. Journal of Molecular Biology. 2004;3381:17–31.15050820, Gregoretti I , Lee Y-M , Goodson H . Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis. Journal of Molecular Biology. 2004;3381:17–31.15050820
-
J. Lexell, C. Taylor, M. Sjöström (1988)
What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old menJournal of the Neurological Sciences, 84
-
M. Fulco, R. Schiltz, S. Iezzi, M. King, P. Zhao, Y. Kashiwaya, E. Hoffman, R. Veech, V. Sartorelli (2003)
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.Molecular cell, 12 1
-
( Iannuzzi-Sucich M , Prestwood K , Kenny A . Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2002;5712.)
Iannuzzi-Sucich M , Prestwood K , Kenny A . Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2002;5712., Iannuzzi-Sucich M , Prestwood K , Kenny A . Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2002;5712.
-
( Tilstra J , Robinson A , Wang J , Gregg S , Clauson C , Reay D , et al NF-κB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of Clinical Investigation. 2012;1227:2601–12.22706308)
Tilstra J , Robinson A , Wang J , Gregg S , Clauson C , Reay D , et al NF-κB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of Clinical Investigation. 2012;1227:2601–12.22706308, Tilstra J , Robinson A , Wang J , Gregg S , Clauson C , Reay D , et al NF-κB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of Clinical Investigation. 2012;1227:2601–12.22706308
-
( Janssen I , Shepard D , Katzmarzyk P , Roubenoff R . The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society. 2004;521:80–5.14687319)
Janssen I , Shepard D , Katzmarzyk P , Roubenoff R . The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society. 2004;521:80–5.14687319, Janssen I , Shepard D , Katzmarzyk P , Roubenoff R . The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society. 2004;521:80–5.14687319
-
Michele Iannuzzi-sucich, K. Prestwood, A. Kenny (2002)
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women.The journals of gerontology. Series A, Biological sciences and medical sciences, 57 12
-
R. Baumgartner, K. Koehler, D. Gallagher, L. Romero, S. Heymsfield, R. Ross, P. Garry, R. Lindeman (1998)
Epidemiology of sarcopenia among the elderly in New Mexico.American journal of epidemiology, 147 8
-
( Winbanks C , Wang B , Beyer C , Koh P , White L , Kantharidis P , et al TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. The Journal of Biological Chemistry. 2011;28616:13805–14.21324893)
Winbanks C , Wang B , Beyer C , Koh P , White L , Kantharidis P , et al TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. The Journal of Biological Chemistry. 2011;28616:13805–14.21324893, Winbanks C , Wang B , Beyer C , Koh P , White L , Kantharidis P , et al TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. The Journal of Biological Chemistry. 2011;28616:13805–14.21324893
-
Z. Gerhart-Hines, J. Rodgers, Olivia Baré, C. Lerin, Seung-hee Kim, R. Mostoslavsky, F. Alt, Zhidan Wu, P. Puigserver (2007)
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1αThe EMBO Journal, 26
-
( Dufour A , Hannan M , Murabito J , Kiel D , McLean R . Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: The Framingham Study. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2013;682:168–74.)
Dufour A , Hannan M , Murabito J , Kiel D , McLean R . Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: The Framingham Study. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2013;682:168–74., Dufour A , Hannan M , Murabito J , Kiel D , McLean R . Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: The Framingham Study. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2013;682:168–74.
-
( Consalvi S , Mozzetta C , Bettica P , Germani M , Fiorentini F , Del Bene F , et al Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat. Molecular Medicine (Cambridge, Mass). 2013;19, 79–87.)
Consalvi S , Mozzetta C , Bettica P , Germani M , Fiorentini F , Del Bene F , et al Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat. Molecular Medicine (Cambridge, Mass). 2013;19, 79–87., Consalvi S , Mozzetta C , Bettica P , Germani M , Fiorentini F , Del Bene F , et al Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat. Molecular Medicine (Cambridge, Mass). 2013;19, 79–87.
-
Christina Tse, T. Sera, A. Wolffe, J. Hansen (1998)
Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase IIIMolecular and Cellular Biology, 18
-
( Minetti G , Colussi C , Adami R , Serra C , Mozzetta C , Parente V , et al Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat Med. 2006advanced online publication(10):1147–50.)
Minetti G , Colussi C , Adami R , Serra C , Mozzetta C , Parente V , et al Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat Med. 2006advanced online publication(10):1147–50., Minetti G , Colussi C , Adami R , Serra C , Mozzetta C , Parente V , et al Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat Med. 2006advanced online publication(10):1147–50.
-
( Jang Y , Lustgarten M , Liu Y , Van Remmen H . Calorie Restriction (CR) Protects against oxidative stress-induced muscle atrophy by preserving mitochondrial function and muscle integrity even in the absence of antioxidant enzyme CuZnSOD. Free Radical Biology and Medicine. 2010;49, S81.)
Jang Y , Lustgarten M , Liu Y , Van Remmen H . Calorie Restriction (CR) Protects against oxidative stress-induced muscle atrophy by preserving mitochondrial function and muscle integrity even in the absence of antioxidant enzyme CuZnSOD. Free Radical Biology and Medicine. 2010;49, S81., Jang Y , Lustgarten M , Liu Y , Van Remmen H . Calorie Restriction (CR) Protects against oxidative stress-induced muscle atrophy by preserving mitochondrial function and muscle integrity even in the absence of antioxidant enzyme CuZnSOD. Free Radical Biology and Medicine. 2010;49, S81.
-
T. White, N. LeBrasseur (2014)
Myostatin and Sarcopenia: Opportunities and Challenges - A Mini-ReviewGerontology, 60
-
( Wang AH , Kruhlak MJ , Wu J , Bertos NR , Vezmar M , Posner BI , et al Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Molecular and Cellular Biology. 2000;2018:6904–12.10958686)
Wang AH , Kruhlak MJ , Wu J , Bertos NR , Vezmar M , Posner BI , et al Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Molecular and Cellular Biology. 2000;2018:6904–12.10958686, Wang AH , Kruhlak MJ , Wu J , Bertos NR , Vezmar M , Posner BI , et al Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Molecular and Cellular Biology. 2000;2018:6904–12.10958686
-
A. Newman, V. Kupelian, M. Visser, E. Simonsick, B. Goodpaster, S. Kritchevsky, F. Tylavsky, S. Rubin, T. Harris (2006)
Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort.The journals of gerontology. Series A, Biological sciences and medical sciences, 61 1
-
A. Dufour, M. Hannan, J. Murabito, D. Kiel, R. McLean (2013)
Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: the Framingham Study.The journals of gerontology. Series A, Biological sciences and medical sciences, 68 2
-
( Cosgrove B , Gilbert P , Porpiglia E , Mourkioti F , Lee S , Corbel S , et al Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine. 2014;203:255–64.)
Cosgrove B , Gilbert P , Porpiglia E , Mourkioti F , Lee S , Corbel S , et al Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine. 2014;203:255–64., Cosgrove B , Gilbert P , Porpiglia E , Mourkioti F , Lee S , Corbel S , et al Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine. 2014;203:255–64.
-
D. Owen, Prisca Ornaghi, Ji-Chun Yang, Nicholas Lowe, P. Evans, P. Ballario, D. Neuhaus, P. Filetici, A. Travers (2000)
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5pThe EMBO Journal, 19
-
( Kohrt WM , Malley MT , Dalsky GP , Holloszy JO . Body composition of healthy sedentary and trained, young and older men and women. Medicine and Science in Sports and Exercise. 1992;247:832–7.1501570)
Kohrt WM , Malley MT , Dalsky GP , Holloszy JO . Body composition of healthy sedentary and trained, young and older men and women. Medicine and Science in Sports and Exercise. 1992;247:832–7.1501570, Kohrt WM , Malley MT , Dalsky GP , Holloszy JO . Body composition of healthy sedentary and trained, young and older men and women. Medicine and Science in Sports and Exercise. 1992;247:832–7.1501570
-
( Dokmanovic M , Clarke C , Marks P . Histone deacetylase inhibitors: Overview and perspectives. Molecular Cancer Research. 2007;510:981–9.17951399)
Dokmanovic M , Clarke C , Marks P . Histone deacetylase inhibitors: Overview and perspectives. Molecular Cancer Research. 2007;510:981–9.17951399, Dokmanovic M , Clarke C , Marks P . Histone deacetylase inhibitors: Overview and perspectives. Molecular Cancer Research. 2007;510:981–9.17951399
-
( Rudolf R , Khan MM , Labeit S , Deschenes M . Degeneration of neuromuscular junction in age and dystrophy. Frontiers in Aging Neuroscience. 2014;6.24570662)
Rudolf R , Khan MM , Labeit S , Deschenes M . Degeneration of neuromuscular junction in age and dystrophy. Frontiers in Aging Neuroscience. 2014;6.24570662, Rudolf R , Khan MM , Labeit S , Deschenes M . Degeneration of neuromuscular junction in age and dystrophy. Frontiers in Aging Neuroscience. 2014;6.24570662
-
J. Tidball (2015)
Faculty Opinions recommendation of Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. -
( Bricceno K , Sampognaro P , Van Meerbeke J , Sumner C , Fischbeck K , Burnett B . Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice. Human Molecular Genetics. 2012;2120:4448–59.22798624)
Bricceno K , Sampognaro P , Van Meerbeke J , Sumner C , Fischbeck K , Burnett B . Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice. Human Molecular Genetics. 2012;2120:4448–59.22798624, Bricceno K , Sampognaro P , Van Meerbeke J , Sumner C , Fischbeck K , Burnett B . Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice. Human Molecular Genetics. 2012;2120:4448–59.22798624
-
( Minamiyama M , Katsuno M , Adachi H , Waza M , Sang C , Kobayashi Y , et al Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Human Molecular Genetics. 2004;1311.)
Minamiyama M , Katsuno M , Adachi H , Waza M , Sang C , Kobayashi Y , et al Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Human Molecular Genetics. 2004;1311., Minamiyama M , Katsuno M , Adachi H , Waza M , Sang C , Kobayashi Y , et al Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Human Molecular Genetics. 2004;1311.
-
( Lexell J , Taylor C , Sjöström M . What is the cause of the ageing atrophy? Journal of the Neurological Sciences 1988;842-3:275–94.3379447)
Lexell J , Taylor C , Sjöström M . What is the cause of the ageing atrophy? Journal of the Neurological Sciences 1988;842-3:275–94.3379447, Lexell J , Taylor C , Sjöström M . What is the cause of the ageing atrophy? Journal of the Neurological Sciences 1988;842-3:275–94.3379447
-
L. Combaret, D. Dardevet, D. Béchet, D. Taillandier, L. Mosoni, D. Attaix (2009)
Skeletal muscle proteolysis in agingCurrent Opinion in Clinical Nutrition and Metabolic Care, 12
-
( Puri PL , Sartorelli V , Yang XJ , Hamamori Y , Ogryzko VV , Howard BH , et al Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Molecular Cell. 1997;11:35–45.9659901)
Puri PL , Sartorelli V , Yang XJ , Hamamori Y , Ogryzko VV , Howard BH , et al Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Molecular Cell. 1997;11:35–45.9659901, Puri PL , Sartorelli V , Yang XJ , Hamamori Y , Ogryzko VV , Howard BH , et al Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Molecular Cell. 1997;11:35–45.9659901
-
( Shimazu T , Hirschey M , Newman J , He W , Shirakawa K , Le Moan N , et al Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, NY). 2013;3396116:211–4.)
Shimazu T , Hirschey M , Newman J , He W , Shirakawa K , Le Moan N , et al Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, NY). 2013;3396116:211–4., Shimazu T , Hirschey M , Newman J , He W , Shirakawa K , Le Moan N , et al Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, NY). 2013;3396116:211–4.
-
( Merritt E , Stec M , Thalacker-Mercer A , Windham S , Cross J , Shelley D , et al Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. Journal of Applied Physiology. 2013;1156:937–48.23681911)
Merritt E , Stec M , Thalacker-Mercer A , Windham S , Cross J , Shelley D , et al Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. Journal of Applied Physiology. 2013;1156:937–48.23681911, Merritt E , Stec M , Thalacker-Mercer A , Windham S , Cross J , Shelley D , et al Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. Journal of Applied Physiology. 2013;1156:937–48.23681911
-
( Combaret L , Dardevet D , Béchet D , Taillandier D , Mosoni L , Attaix D . Skeletal muscle proteolysis in aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2009;121:37–41.19057185)
Combaret L , Dardevet D , Béchet D , Taillandier D , Mosoni L , Attaix D . Skeletal muscle proteolysis in aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2009;121:37–41.19057185, Combaret L , Dardevet D , Béchet D , Taillandier D , Mosoni L , Attaix D . Skeletal muscle proteolysis in aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2009;121:37–41.19057185
-
O. Rooyackers, D. Adey, P. Ades, K. Nair (1996)
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America, 93 26
-
( Balagopal P , Rooyackers OE , Adey DB , Ades PA , Nair KS . Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol. 1997;2734 Pt 1:E790–800.9357810)
Balagopal P , Rooyackers OE , Adey DB , Ades PA , Nair KS . Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol. 1997;2734 Pt 1:E790–800.9357810, Balagopal P , Rooyackers OE , Adey DB , Ades PA , Nair KS . Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol. 1997;2734 Pt 1:E790–800.9357810
-
(2014)
D-beta-hydroxybutyrate extends lifespan in C. elegansAging (Albany NY), 6
-
( Luo L , Lu AM , Wang Y , Hong A , Chen Y , Hu J , et al Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Experimental Gerontology. 2013;484:427–36.23419688)
Luo L , Lu AM , Wang Y , Hong A , Chen Y , Hu J , et al Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Experimental Gerontology. 2013;484:427–36.23419688, Luo L , Lu AM , Wang Y , Hong A , Chen Y , Hu J , et al Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Experimental Gerontology. 2013;484:427–36.23419688
-
Lei Chen, D. Nelson, Yang Zhao, Z. Cui, J. Johnston (2013)
Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United StatesBMC Geriatrics, 13
-
( Ma K , Chan J , Zhu G , Wu Z . Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Molecular and Cellular Biology. 2005;259:3575–82.15831463)
Ma K , Chan J , Zhu G , Wu Z . Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Molecular and Cellular Biology. 2005;259:3575–82.15831463, Ma K , Chan J , Zhu G , Wu Z . Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Molecular and Cellular Biology. 2005;259:3575–82.15831463
-
( Williams A , Valdez G , Moresi V , Qi X , McAnally J , Elliott J , et al MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;3265959:1549–54.20007902)
Williams A , Valdez G , Moresi V , Qi X , McAnally J , Elliott J , et al MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;3265959:1549–54.20007902, Williams A , Valdez G , Moresi V , Qi X , McAnally J , Elliott J , et al MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;3265959:1549–54.20007902
-
S. McGee, B. Denderen, K. Howlett, J. Mollica, J. Schertzer, B. Kemp, M. Hargreaves (2008)
AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5Diabetes, 57
-
( Bigot A , Jacquemin V , Debacq-Chainiaux F , Butler-Browne G , Toussaint O , Furling D , et al Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 2008;1003:189–99.)
Bigot A , Jacquemin V , Debacq-Chainiaux F , Butler-Browne G , Toussaint O , Furling D , et al Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 2008;1003:189–99., Bigot A , Jacquemin V , Debacq-Chainiaux F , Butler-Browne G , Toussaint O , Furling D , et al Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 2008;1003:189–99.
-
M. Egerman, S. Cadena, J. Gilbert, Angelika Meyer, Hallie Nelson, Susanne Swalley, Carolyn Mallozzi, C. Jacobi, L. Jennings, I. Clay, G. Laurent, Shengling Ma, S. Brachat, E. Lach‐Trifilieff, T. Shavlakadze, A. Trendelenburg, A. Brack, D. Glass (2015)
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.Cell metabolism, 22 1
-
Li Luo, A-Ming Lu, Yan Wang, Anlan Hong, Yulan Chen, Juan Hu, Xiaoning Li, Zheng-Hong Qin (2013)
Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged ratsExperimental Gerontology, 48
-
E. Marzetti, J. Lawler, A. Hiona, T. Manini, Arnold Seo, C. Leeuwenburgh (2008)
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.Free radical biology & medicine, 44 2
-
W. Oh, David Gardner, M. Devonald (2008)
Current opinion in clinical nutrition and metabolic care.Current opinion in clinical nutrition and metabolic care, 11 5
-
A. Joe, L. Yi, Anuradha Natarajan, F. Grand, L. So, Joyce Wang, M. Rudnicki, F. Rossi (2010)
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesisNature Cell Biology, 12
-
( Raichur S , Teh SH , Ohwaki K , Gaur V , Long YC , Hargreaves M , et al Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells. Journal of Molecular Endocrinology. 2012;493:203–11.22991226)
Raichur S , Teh SH , Ohwaki K , Gaur V , Long YC , Hargreaves M , et al Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells. Journal of Molecular Endocrinology. 2012;493:203–11.22991226, Raichur S , Teh SH , Ohwaki K , Gaur V , Long YC , Hargreaves M , et al Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells. Journal of Molecular Endocrinology. 2012;493:203–11.22991226
-
Young-eun Yoo, C. Ko (2011)
Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosisExperimental Neurology, 231
-
L. Edström, L. Larsson (1987)
Effects of age on contractile and enzyme‐histochemical properties of fast‐ and slow‐twitch single motor units in the rat.The Journal of Physiology, 392
-
I. Janssen, D. Shepard, P. Katzmarzyk, R. Roubenoff (2004)
The Healthcare Costs of Sarcopenia in the United StatesJournal of the American Geriatrics Society, 52
-
A. Gomes, Nathan Price, A. Ling, J. Moslehi, M. Montgomery, Luis Rajman, James White, J. Teodoro, C. Wrann, Basil Hubbard, E. Mercken, C. Palmeira, R. Cabo, A. Rolo, N. Turner, Eric Bell, D. Sinclair (2013)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during AgingCell, 155
-
R. Berdeaux, N. Goebel, Laura Banaszynski, H. Takemori, T. Wandless, Diane Shelton, M. Montminy (2007)
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytesNature Medicine, 13
-
Nashwa Cheema, Allen Herbst, D. McKenzie, J. Aiken (2015)
Apoptosis and necrosis mediate skeletal muscle fiber loss in age‐induced mitochondrial enzymatic abnormalitiesAging Cell, 14
-
A. Cruz-Jentoft, J. Baeyens, J. Bauer, Y. Boirie, T. Cederholm, F. Landi, F. Martin, J. Michel, Y. Rolland, S. Schneider, E. Topinkova, M. Vandewoude, M. Zamboni (2010)
Sarcopenia: European consensus on definition and diagnosisAge and Ageing, 39
-
( Koopman R , Verdijk L , Manders R , Gijsen A , Gorselink M , Pijpers E , et al Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. The American Journal of Clinical Nutrition. 2006;843:623–32.16960178)
Koopman R , Verdijk L , Manders R , Gijsen A , Gorselink M , Pijpers E , et al Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. The American Journal of Clinical Nutrition. 2006;843:623–32.16960178, Koopman R , Verdijk L , Manders R , Gijsen A , Gorselink M , Pijpers E , et al Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. The American Journal of Clinical Nutrition. 2006;843:623–32.16960178
-
( Opalach K , Rangaraju S , Madorsky I , Leeuwenburgh C , Notterpek L . Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Research. 2010;131:65–74.20230280)
Opalach K , Rangaraju S , Madorsky I , Leeuwenburgh C , Notterpek L . Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Research. 2010;131:65–74.20230280, Opalach K , Rangaraju S , Madorsky I , Leeuwenburgh C , Notterpek L . Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Research. 2010;131:65–74.20230280
-
( Morley J . Sarcopenia in the elderly. Family Practice. 2012;29suppl 1:i44–i8.22399555)
Morley J . Sarcopenia in the elderly. Family Practice. 2012;29suppl 1:i44–i8.22399555, Morley J . Sarcopenia in the elderly. Family Practice. 2012;29suppl 1:i44–i8.22399555
-
J. Faulkner, L. Larkin, D. Claflin, S. Brooks (2007)
AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLESClinical and Experimental Pharmacology and Physiology, 34
-
R. Roubenoff, H. Parise, H. Payette, L. Abad, R. D'Agostino, P. Jacques, P. Wilson, C. Dinarello, T. Harris (2003)
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study.The American journal of medicine, 115 6
-
T. Reed, R. Fabsitz, J. Selby, D. Carmelli (1991)
Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69.Annals of human biology, 18 5
-
( Moresi V , Carrer M , Grueter C , Rifki O , Shelton J , Richardson J , et al Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2012;1095:1649–54.22307625)
Moresi V , Carrer M , Grueter C , Rifki O , Shelton J , Richardson J , et al Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2012;1095:1649–54.22307625, Moresi V , Carrer M , Grueter C , Rifki O , Shelton J , Richardson J , et al Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2012;1095:1649–54.22307625
-
Jian-rong Lu, T. McKinsey, R. Nicol, E. Olson (2000)
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.Proceedings of the National Academy of Sciences of the United States of America, 97 8
-
Ivan Gregoretti, Yun-Mi Lee, H. Goodson (2004)
Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.Journal of molecular biology, 338 1
-
Audrey Wang, N. Bertos, Marko Vezmar, N. Pelletier, M. Crosato, H. Heng, J. Th’ng, Jiahuai Han, Xiang-Jiao Yang (1999)
HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional CorepressorMolecular and Cellular Biology, 19
-
( Metter J , Talbot L , Schrager M , Conwit R . Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;5710:B359–65.12242311)
Metter J , Talbot L , Schrager M , Conwit R . Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;5710:B359–65.12242311, Metter J , Talbot L , Schrager M , Conwit R . Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;5710:B359–65.12242311
-
( Johnston A , Murphy K , Jenkinson L , Laine D , Emmrich K , Faou P , et al Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival. Cell. 2015;1626:1365–78.26359988)
Johnston A , Murphy K , Jenkinson L , Laine D , Emmrich K , Faou P , et al Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival. Cell. 2015;1626:1365–78.26359988, Johnston A , Murphy K , Jenkinson L , Laine D , Emmrich K , Faou P , et al Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival. Cell. 2015;1626:1365–78.26359988
-
Matthew Potthoff, Hai Wu, Michael Arnold, J. Shelton, J. Backs, J. McAnally, J. Richardson, R. Bassel-Duby, E. Olson (2007)
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.The Journal of clinical investigation, 117 9
-
Y. Jang, Yuhong Liu, C. Hayworth, A. Bhattacharya, M. Lustgarten, Florian Muller, A. Chaudhuri, W. Qi, Yan Li, Jing-Yi Huang, E. Verdin, A. Richardson, H. Remmen (2012)
Dietary restriction attenuates age‐associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSODAging Cell, 11
-
D. Carmelli, Terry Reed (2000)
Stability and change in genetic and environmental influences on hand-grip strength in older male twins.Journal of applied physiology, 89 5
-
( Shefer G , Van de Mark D , Richardson J , Yablonka-Reuveni Z . Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle. Developmental Biology. 2006;2941:50–66.16554047)
Shefer G , Van de Mark D , Richardson J , Yablonka-Reuveni Z . Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle. Developmental Biology. 2006;2941:50–66.16554047, Shefer G , Van de Mark D , Richardson J , Yablonka-Reuveni Z . Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle. Developmental Biology. 2006;2941:50–66.16554047
-
( Castillo E , Goodman-Gruen D , Kritz-Silverstein D , Morton D , Wingard D , Barrett-Connor E . Sarcopenia in elderly men and women: The Rancho Bernardo study. American Journal of Preventive Medicine. 2003;253:226–31.14507529)
Castillo E , Goodman-Gruen D , Kritz-Silverstein D , Morton D , Wingard D , Barrett-Connor E . Sarcopenia in elderly men and women: The Rancho Bernardo study. American Journal of Preventive Medicine. 2003;253:226–31.14507529, Castillo E , Goodman-Gruen D , Kritz-Silverstein D , Morton D , Wingard D , Barrett-Connor E . Sarcopenia in elderly men and women: The Rancho Bernardo study. American Journal of Preventive Medicine. 2003;253:226–31.14507529
-
( Bouchard D , Héroux M , Janssen I . Association between muscle mass, leg strength, and fat mass with physical function in older adults: Influence of age and sex. Journal of Aging and Health. 2011;232:313–28.21081704)
Bouchard D , Héroux M , Janssen I . Association between muscle mass, leg strength, and fat mass with physical function in older adults: Influence of age and sex. Journal of Aging and Health. 2011;232:313–28.21081704, Bouchard D , Héroux M , Janssen I . Association between muscle mass, leg strength, and fat mass with physical function in older adults: Influence of age and sex. Journal of Aging and Health. 2011;232:313–28.21081704
-
( Kim S , Benguria A , Lai CY , Jazwinski SM . Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Molecular Biology of the Cell. 1999;1010:3125–36.10512855)
Kim S , Benguria A , Lai CY , Jazwinski SM . Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Molecular Biology of the Cell. 1999;1010:3125–36.10512855, Kim S , Benguria A , Lai CY , Jazwinski SM . Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Molecular Biology of the Cell. 1999;1010:3125–36.10512855
-
( Yoo Y-E , Ko C-P . Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 2011;2311:147–59.21712032)
Yoo Y-E , Ko C-P . Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 2011;2311:147–59.21712032, Yoo Y-E , Ko C-P . Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 2011;2311:147–59.21712032
-
D. Christensen, M. Dahllöf, M. Lundh, D. Rasmussen, M. Nielsen, N. Billestrup, L. Grunnet, T. Mandrup-Poulsen (2011)
Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes MellitusMolecular Medicine, 17
-
W. Huygens, M. Thomis, M. Peeters, Jeroen Aerssens, Jeroen Aerssens, R. Vlietinck, R. Vlietinck, G. Beunen (2005)
Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes.Physiological genomics, 22 3
-
( Rantanen T , Harris T , Leveille S , Visser M , Foley D , Masaki K , et al Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2000;553:M168–73.)
Rantanen T , Harris T , Leveille S , Visser M , Foley D , Masaki K , et al Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2000;553:M168–73., Rantanen T , Harris T , Leveille S , Visser M , Foley D , Masaki K , et al Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2000;553:M168–73.
-
Huibin Tang, P. Macpherson, Michael Marvin, Eric Meadows, W. Klein, Xiang-Jiao Yang, D. Goldman (2009)
A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression.Molecular biology of the cell, 20 4
-
Zhanguo Gao, Jun-yi Yin, Jin Zhang, R. Ward, Roy Martin, M. Lefevre, W. Cefalu, Jianping Ye (2009)
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in MiceDiabetes, 58
-
Ian Lanza, P. Zabielski, Katherine Klaus, Dawn Morse, C. Heppelmann, H. Bergen, S. Dasari, S. Walrand, K. Short, Matthew Johnson, M. Robinson, J. Schimke, D. Jakaitis, Y. Asmann, Zhi-fu Sun, K. Nair (2012)
Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.Cell metabolism, 16 6
-
( Cheema N , Herbst A , McKenzie D , Aiken J . Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell. 2015;146:1085–93.26365892)
Cheema N , Herbst A , McKenzie D , Aiken J . Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell. 2015;146:1085–93.26365892, Cheema N , Herbst A , McKenzie D , Aiken J . Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell. 2015;146:1085–93.26365892
-
P. Srikanthan, A. Karlamangla (2014)
Muscle mass index as a predictor of longevity in older adults.The American journal of medicine, 127 6
-
T. Buford, M. Cooke, T. Manini, C. Leeuwenburgh, D. Willoughby (2010)
Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men.The journals of gerontology. Series A, Biological sciences and medical sciences, 65 5
-
G. Minetti, C. Colussi, R. Adami, C. Serra, C. Mozzetta, V. Parente, S. Fortuni, S. Straino, M. Sampaolesi, M. Padova, B. Illi, P. Gallinari, C. Steinkühler, M. Capogrossi, V. Sartorelli, R. Bottinelli, C. Gaetano, P. Puri (2006)
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitorsNature Medicine, 12
-
( Cree M , Newcomer B , Katsanos C , Sheffield-Moore M , Chinkes D , Aarsland A , et al Intramuscular and liver triglycerides are increased in the elderly. The Journal of Clinical Endocrinology and Metabolism. 2004;898:3864–71.15292319)
Cree M , Newcomer B , Katsanos C , Sheffield-Moore M , Chinkes D , Aarsland A , et al Intramuscular and liver triglycerides are increased in the elderly. The Journal of Clinical Endocrinology and Metabolism. 2004;898:3864–71.15292319, Cree M , Newcomer B , Katsanos C , Sheffield-Moore M , Chinkes D , Aarsland A , et al Intramuscular and liver triglycerides are increased in the elderly. The Journal of Clinical Endocrinology and Metabolism. 2004;898:3864–71.15292319
-
A. Galmozzi, N. Mitro, A. Ferrari, E. Gers, F. Gilardi, C. Godio, G. Cermenati, A. Gualerzi, E. Donetti, D. Rotili, S. Valente, U. Guerrini, D. Caruso, A. Mai, E. Saez, E. Fabiani, M. Crestani (2013)
Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose TissueDiabetes, 62
-
( Hawkins S , Wiswell R , Marcell T . Exercise and the master athlete— a model of successful aging? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2003;5811:M1009–M11.)
Hawkins S , Wiswell R , Marcell T . Exercise and the master athlete— a model of successful aging? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2003;5811:M1009–M11., Hawkins S , Wiswell R , Marcell T . Exercise and the master athlete— a model of successful aging? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2003;5811:M1009–M11.
-
H. Yousef, M. Conboy, Adam Morgenthaler, C. Schlesinger, Lukasz Bugaj, P. Paliwal, Christopher Greer, I. Conboy, D. Schaffer (2015)
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammalOncotarget, 6
-
( Tse C , Sera T , Wolffe AP , Hansen JC . Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Molecular and Cellular Biology. 1998;188:4629–38.9671473)
Tse C , Sera T , Wolffe AP , Hansen JC . Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Molecular and Cellular Biology. 1998;188:4629–38.9671473, Tse C , Sera T , Wolffe AP , Hansen JC . Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Molecular and Cellular Biology. 1998;188:4629–38.9671473
-
( Hamilton R , Bhattacharya A , Walsh M , Shi Y , Wei R , Zhang Y , et al Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and sod1–/– mice: Plausible link between oxidative stress and demyelination. PloS One. 2013;86:e65725.23750273)
Hamilton R , Bhattacharya A , Walsh M , Shi Y , Wei R , Zhang Y , et al Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and sod1–/– mice: Plausible link between oxidative stress and demyelination. PloS One. 2013;86:e65725.23750273, Hamilton R , Bhattacharya A , Walsh M , Shi Y , Wei R , Zhang Y , et al Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and sod1–/– mice: Plausible link between oxidative stress and demyelination. PloS One. 2013;86:e65725.23750273
-
Victoria Siriett, Leanne Platt, M. Salerno, Nicholas Ling, R. Kambadur, Mridula Sharma (2006)
Prolonged absence of myostatin reduces sarcopeniaJournal of Cellular Physiology, 209
-
( Yabumoto C , Akazawa H , Yamamoto R , Yano M , Kudo-Sakamoto Y , Sumida T , et al Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports. 2015;5, 14453.26571361)
Yabumoto C , Akazawa H , Yamamoto R , Yano M , Kudo-Sakamoto Y , Sumida T , et al Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports. 2015;5, 14453.26571361, Yabumoto C , Akazawa H , Yamamoto R , Yano M , Kudo-Sakamoto Y , Sumida T , et al Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression. Scientific Reports. 2015;5, 14453.26571361
-
( Senf S , Sandesara P , Reed S , Judge A . p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. American Journal of Physiology Cell Physiology. 2011);3006.)
Senf S , Sandesara P , Reed S , Judge A . p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. American Journal of Physiology Cell Physiology. 2011);3006., Senf S , Sandesara P , Reed S , Judge A . p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. American Journal of Physiology Cell Physiology. 2011);3006.
-
( Husom A , Peters E , Kolling E , Fugere N , Thompson L , Ferrington D . Altered proteasome function and subunit composition in aged muscle. Archives of Biochemistry and Biophysics. 2004;4211:67–76.14678786)
Husom A , Peters E , Kolling E , Fugere N , Thompson L , Ferrington D . Altered proteasome function and subunit composition in aged muscle. Archives of Biochemistry and Biophysics. 2004;4211:67–76.14678786, Husom A , Peters E , Kolling E , Fugere N , Thompson L , Ferrington D . Altered proteasome function and subunit composition in aged muscle. Archives of Biochemistry and Biophysics. 2004;4211:67–76.14678786
-
Chizuru Yabumoto, H. Akazawa, R. Yamamoto, M. Yano, Yoko Kudo-Sakamoto, Tomokazu Sumida, Takehiro Kamo, Hiroki Yagi, Yu Shimizu, A. Saga-Kamo, A. Naito, T. Oka, Jong-Kook Lee, J. Suzuki, Y. Sakata, E. Uejima, I. Komuro (2015)
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expressionScientific Reports, 5
-
R. Hepple, Maggie Qin, H. Nakamoto, S. Goto (2008)
Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia.American journal of physiology. Regulatory, integrative and comparative physiology, 295 4
-
T. Cohen, D. Waddell, T. Barrientos, Zhonghua Lu, G. Feng, G. Cox, S. Bodine, T. Yao (2007)
The Histone Deacetylase HDAC4 Connects Neural Activity to Muscle Transcriptional Reprogramming*Journal of Biological Chemistry, 282
-
( Carnio S , LoVerso F , Baraibar M , Longa E , Khan M , Maffei M , et al Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Reports. 2014;85:1509–21.25176656)
Carnio S , LoVerso F , Baraibar M , Longa E , Khan M , Maffei M , et al Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Reports. 2014;85:1509–21.25176656, Carnio S , LoVerso F , Baraibar M , Longa E , Khan M , Maffei M , et al Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging. Cell Reports. 2014;85:1509–21.25176656
-
( Potthoff M , Wu H , Arnold M , Shelton J , Backs J , McAnally J , et al Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. The Journal of Clinical Investigation. 2007;1179:2459–67.17786239)
Potthoff M , Wu H , Arnold M , Shelton J , Backs J , McAnally J , et al Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. The Journal of Clinical Investigation. 2007;1179:2459–67.17786239, Potthoff M , Wu H , Arnold M , Shelton J , Backs J , McAnally J , et al Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. The Journal of Clinical Investigation. 2007;1179:2459–67.17786239
-
( Symons B , Sheffield-Moore M , Wolfe R , Paddon-Jones D . A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. Journal of the American Dietetic Association. 2009;1099:1582–6.19699838)
Symons B , Sheffield-Moore M , Wolfe R , Paddon-Jones D . A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. Journal of the American Dietetic Association. 2009;1099:1582–6.19699838, Symons B , Sheffield-Moore M , Wolfe R , Paddon-Jones D . A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. Journal of the American Dietetic Association. 2009;1099:1582–6.19699838
-
( Tajrishi M , Sato S , Shin J , Zheng T , Burkly L , Kumar A . The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle. Biochemical and Biophysical Research Communications. 2014;4464:1219–24.24680686)
Tajrishi M , Sato S , Shin J , Zheng T , Burkly L , Kumar A . The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle. Biochemical and Biophysical Research Communications. 2014;4464:1219–24.24680686, Tajrishi M , Sato S , Shin J , Zheng T , Burkly L , Kumar A . The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle. Biochemical and Biophysical Research Communications. 2014;4464:1219–24.24680686
-
Y. Jang, M. Lustgarten, Yuhong Liu, H. Remmen (2010)
Calorie Restriction (CR) Protects against Oxidative Stress-induced Muscle Atrophy by Preserving Mitochondrial Function and Muscle Integrity Even in the Absence of Antioxidant Enzyme CuZnSODFree Radical Biology and Medicine, 49
-
V. Moresi, Andrew Williams, Eric Meadows, Jesse Flynn, Matthew Potthoff, J. McAnally, J. Shelton, J. Backs, W. Klein, J. Richardson, R. Bassel-Duby, E. Olson (2010)
Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin LigasesCell, 143
-
E. Edström, M. Altun, Martin Hägglund, B. Ulfhake (2006)
Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.The journals of gerontology. Series A, Biological sciences and medical sciences, 61 7
-
Marjolein Visser, Marjolein Visser (2009)
Towards a definition of sarcopenia — results from epidemiologic studiesJNHA - The Journal of Nutrition, Health and Aging, 13
-
( Lee J-Y , Koga H , Kawaguchi Y , Tang W , Wong E , Gao Y-S , et al HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. advance online publication. 2010;5 969–80.)
Lee J-Y , Koga H , Kawaguchi Y , Tang W , Wong E , Gao Y-S , et al HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. advance online publication. 2010;5 969–80., Lee J-Y , Koga H , Kawaguchi Y , Tang W , Wong E , Gao Y-S , et al HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. advance online publication. 2010;5 969–80.
-
( Colussi C , Mozzetta C , Gurtner A , Illi B , Rosati J , Straino S , et al HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proceedings of the National Academy of Sciences. 2008;10549:19183–7.)
Colussi C , Mozzetta C , Gurtner A , Illi B , Rosati J , Straino S , et al HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proceedings of the National Academy of Sciences. 2008;10549:19183–7., Colussi C , Mozzetta C , Gurtner A , Illi B , Rosati J , Straino S , et al HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proceedings of the National Academy of Sciences. 2008;10549:19183–7.
-
M. Sinha, Young Jang, Juhyun Oh, D. Khong, Elizabeth Wu, R. Manohar, Christine Miller, Samuel Regalado, F. Loffredo, James Pancoast, M. Hirshman, Jessica Lebowitz, J. Shadrach, M. Cerletti, Mi‐jeong Kim, T. Serwold, L. Goodyear, B. Rosner, Richard Lee, A. Wagers (2014)
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal MuscleScience, 344
-
J. Tilstra, A. Robinson, Jin Wang, Siobhán Gregg, Cheryl Clauson, D. Reay, L. Nasto, C. Croix, A. Usas, N. Vo, J. Huard, P. Clemens, D. Stolz, D. Guttridge, Simon Watkins, G. Garinis, Yinsheng Wang, L. Niedernhofer, P. Robbins (2012)
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.The Journal of clinical investigation, 122 7
-
A. Bigot, V. Jacquemin, F. Debacq-Chainiaux, G. Butler-Browne, O. Toussaint, D. Furling, V. Mouly (2008)
Replicative aging down‐regulates the myogenic regulatory factors in human myoblastsBiology of the Cell, 100
-
( Cruz-Jentoft A , Baeyens J , Bauer J , Boirie Y , Cederholm T , Landi F , et al Sarcopenia: European consensus on definition and diagnosis. Age and Ageing. 2010;394:412–23.20392703)
Cruz-Jentoft A , Baeyens J , Bauer J , Boirie Y , Cederholm T , Landi F , et al Sarcopenia: European consensus on definition and diagnosis. Age and Ageing. 2010;394:412–23.20392703, Cruz-Jentoft A , Baeyens J , Bauer J , Boirie Y , Cederholm T , Landi F , et al Sarcopenia: European consensus on definition and diagnosis. Age and Ageing. 2010;394:412–23.20392703
-
J. Morley (2012)
Sarcopenia in the elderly.Family practice, 29 Suppl 1
-
( Dietz K , Casaccia P . HDAC inhibitors and neurodegeneration: At the edge between protection and damage. Pharmacological Research: The Official Journal of the Italian Pharmacological Society. 2010;621:11–7.)
Dietz K , Casaccia P . HDAC inhibitors and neurodegeneration: At the edge between protection and damage. Pharmacological Research: The Official Journal of the Italian Pharmacological Society. 2010;621:11–7., Dietz K , Casaccia P . HDAC inhibitors and neurodegeneration: At the edge between protection and damage. Pharmacological Research: The Official Journal of the Italian Pharmacological Society. 2010;621:11–7.
-
B. Fling, C. Knight, G. Kamen (2009)
Relationships between motor unit size and recruitment threshold in older adults: implications for size principleExperimental Brain Research, 197
-
Jan-Gowth Chang, H. Hsieh-Li, Y. Jong, Nancy Wang, C. Tsai, Hung Li (2001)
Treatment of spinal muscular atrophy by sodium butyrateProceedings of the National Academy of Sciences of the United States of America, 98
-
Sorabh Sharma, R. Taliyan, Shruti Ramagiri (2014)
Histone Deacetylase Inhibitor, Trichostatin A, Improves Learning and Memory in High-Fat Diet-Induced Cognitive Deficits in MiceJournal of Molecular Neuroscience, 56
-
E. Metter, L. Talbot, M. Schrager, M. Schrager, R. Conwit (2002)
Skeletal muscle strength as a predictor of all-cause mortality in healthy men.The journals of gerontology. Series A, Biological sciences and medical sciences, 57 10
-
R. Wiswell, S. Hawkins, S. Jaque, D. Hyslop, N. Constantino, K. Tarpenning, T. Marcell, E. Schroeder (2001)
Relationship between physiological loss, performance decrement, and age in master athletes.The journals of gerontology. Series A, Biological sciences and medical sciences, 56 10
-
( Beharry A , Sandesara P , Roberts B , Ferreira L , Senf S , Judge A . HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Journal of Cell Science. 2014;127Pt 7:1441–53.24463822)
Beharry A , Sandesara P , Roberts B , Ferreira L , Senf S , Judge A . HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Journal of Cell Science. 2014;127Pt 7:1441–53.24463822, Beharry A , Sandesara P , Roberts B , Ferreira L , Senf S , Judge A . HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Journal of Cell Science. 2014;127Pt 7:1441–53.24463822
-
Sean McGee, C. Swinton, Shona Morrison, Vidhi Gaur, Duncan Campbell, Duncan Campbell, S. Jørgensen, Bruce Kemp, K. Baar, Gregory Steinberg, Mark Hargreaves (2014)
Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stressThe FASEB Journal, 28
-
Sophie Chargé, A. Brack, S. Hughes (2002)
Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy.American journal of physiology. Cell physiology, 283 4
-
( Attaix D , Mosoni L , Dardevet D , Combaret L , Mirand PP , Grizard J . Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. The International Journal of Biochemistry & Cell Biology. 2005;3710:1962–73.15905114)
Attaix D , Mosoni L , Dardevet D , Combaret L , Mirand PP , Grizard J . Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. The International Journal of Biochemistry & Cell Biology. 2005;3710:1962–73.15905114, Attaix D , Mosoni L , Dardevet D , Combaret L , Mirand PP , Grizard J . Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. The International Journal of Biochemistry & Cell Biology. 2005;3710:1962–73.15905114
-
S. Dupré-Aucouturier, J. Castells, D. Freyssenet, D. Desplanches (2015)
Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy.Journal of applied physiology, 119 4
-
T. Rantanen, S. Volpato, MD Ferrucci, MD Heikkinen, L. Fried, J. Guralnik (2003)
Handgrip Strength and Cause‐Specific and Total Mortality in Older Disabled Women: Exploring the MechanismJournal of the American Geriatrics Society, 51
-
( Chatterjee T , Basford J , Yiew KH , Stepp D , Hui D , Weintraub N . Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease. Adipocyte. 2014;34:333–8.26317058)
Chatterjee T , Basford J , Yiew KH , Stepp D , Hui D , Weintraub N . Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease. Adipocyte. 2014;34:333–8.26317058, Chatterjee T , Basford J , Yiew KH , Stepp D , Hui D , Weintraub N . Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease. Adipocyte. 2014;34:333–8.26317058
-
Samia Metwally, J. Rowland, Lizhe Xu, S. Zaki, S. Nichol, P. Rollin, J. Towner, Brigid Batten, Tara Sealy, C. Carrillo, K. Moran, A. Bracht, G. Mayr, Magdalena Sirios-Cruz, Davinio Catbagan, E. Lautner, T. Ksiazek, W. White, M. McIntosh (2009)
Caloric Restriction Delays Disease Onset and Mortality in Rhesus MonkeysScience, 325
-
( Ropero S , Esteller M . The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology. 2007;11:19–25.19383284)
Ropero S , Esteller M . The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology. 2007;11:19–25.19383284, Ropero S , Esteller M . The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology. 2007;11:19–25.19383284
-
Sangkyu Kim, A. Benguría, Chi-Yung Lai, S. Jazwinski (1999)
Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.Molecular biology of the cell, 10 10
-
R. Hamilton, A. Bhattacharya, Michael Walsh, Yun Shi, Rochelle Wei, Yiqiang Zhang, K. Rodriguez, R. Buffenstein, A. Chaudhuri, H. Remmen (2013)
Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and DemyelinationPLoS ONE, 8
-
( Tang H , Macpherson P , Marvin M , Meadows E , Klein W , Yang X-J , et al A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Molecular Biology of the Cell. 2009;204:1120–31.19109424)
Tang H , Macpherson P , Marvin M , Meadows E , Klein W , Yang X-J , et al A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Molecular Biology of the Cell. 2009;204:1120–31.19109424, Tang H , Macpherson P , Marvin M , Meadows E , Klein W , Yang X-J , et al A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Molecular Biology of the Cell. 2009;204:1120–31.19109424
-
( Sehl ME , Yates FE . Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2001;565.)
Sehl ME , Yates FE . Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2001;565., Sehl ME , Yates FE . Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2001;565.
-
T. Rantanen, T. Harris, Suzanne Leveille, M. Visser, D. Foley, K. Masaki, J. Guralnik (2000)
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men.The journals of gerontology. Series A, Biological sciences and medical sciences, 55 3
-
J. Lexell (1997)
Evidence for nervous system degeneration with advancing age.The Journal of nutrition, 127 5 Suppl
-
T. Symons, M. Sheffield-Moore, Robert Wolfe, D. Paddon-Jones (2009)
A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects.Journal of the American Dietetic Association, 109 9
-
Mi-Sung Kim, J. Fielitz, John McAnally, J. Shelton, D. Lemon, T. McKinsey, J. Richardson, R. Bassel-Duby, E. Olson (2008)
Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle PerformanceMolecular and Cellular Biology, 28
-
( Mal A , Sturniolo M , Schiltz RL , Ghosh MK , Harter ML . A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: Inhibition of the myogenic program. The EMBO Journal. 2001;207:1739–53.11285237)
Mal A , Sturniolo M , Schiltz RL , Ghosh MK , Harter ML . A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: Inhibition of the myogenic program. The EMBO Journal. 2001;207:1739–53.11285237, Mal A , Sturniolo M , Schiltz RL , Ghosh MK , Harter ML . A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: Inhibition of the myogenic program. The EMBO Journal. 2001;207:1739–53.11285237
-
( Léger B , Cartoni R , Praz M , Lamon S , Dériaz O , Crettenand A , et al Akt signalling through GSK-3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. The Journal of Physiology. 2006;5763:923–33.16916907)
Léger B , Cartoni R , Praz M , Lamon S , Dériaz O , Crettenand A , et al Akt signalling through GSK-3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. The Journal of Physiology. 2006;5763:923–33.16916907, Léger B , Cartoni R , Praz M , Lamon S , Dériaz O , Crettenand A , et al Akt signalling through GSK-3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. The Journal of Physiology. 2006;5763:923–33.16916907
-
( Chang JG , Hsieh-Li HM , Jong YJ , Wang NM , Tsai CH , Li H . Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A. 2001;9817:9808–13.11504946)
Chang JG , Hsieh-Li HM , Jong YJ , Wang NM , Tsai CH , Li H . Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A. 2001;9817:9808–13.11504946, Chang JG , Hsieh-Li HM , Jong YJ , Wang NM , Tsai CH , Li H . Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A. 2001;9817:9808–13.11504946
-
P. Puri, P. Puri, Vittorio Sartorelli, Vittorio Sartorelli, Xiang-Jiao Yang, Yasuo Hamamori, Vasily Ogryzko, Bruce Howard, L. Kedes, Jean Wang, Adolf Graessmann, Yoshihiro Nakatani, Massimo Levrero, Massimo Levrero (1997)
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.Molecular cell, 1 1
-
( Newman A , Haggerty C , Goodpaster B , Harris T , Kritchevsky S , Nevitt M , et al Strength and muscle quality in a well-functioning cohort of older adults: The Health, Aging and Body Composition Study. Journal of the American Geriatrics Society. 2003;513:323–30.12588575)
Newman A , Haggerty C , Goodpaster B , Harris T , Kritchevsky S , Nevitt M , et al Strength and muscle quality in a well-functioning cohort of older adults: The Health, Aging and Body Composition Study. Journal of the American Geriatrics Society. 2003;513:323–30.12588575, Newman A , Haggerty C , Goodpaster B , Harris T , Kritchevsky S , Nevitt M , et al Strength and muscle quality in a well-functioning cohort of older adults: The Health, Aging and Body Composition Study. Journal of the American Geriatrics Society. 2003;513:323–30.12588575
-
C. Colussi, C. Mozzetta, A. Gurtner, B. Illi, Jessica Rosati, S. Straino, G. Ragone, M. Pescatori, G. Zaccagnini, A. Antonini, G. Minetti, F. Martelli, G. Piaggio, P. Gallinari, C. Steinkuhler, E. Clementi, C. Dell'Aversana, L. Altucci, A. Mai, M. Capogrossi, P. Puri, C. Gaetano (2008)
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatmentProceedings of the National Academy of Sciences, 105
-
M. Visser, D. Deeg, P. Lips (2003)
Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam.The Journal of clinical endocrinology and metabolism, 88 12
-
Milos Dokmanovic, Cathy Clarke, P. Marks (2007)
Histone Deacetylase Inhibitors: Overview and PerspectivesMolecular Cancer Research, 5
-
S. Ropero, M. Esteller (2007)
The role of histone deacetylases (HDACs) in human cancerMolecular Oncology, 1
-
S. Hawkins, R. Wiswell, T. Marcell (2003)
Exercise and the master athlete--a model of successful aging?The journals of gerontology. Series A, Biological sciences and medical sciences, 58 11
-
Shaun Calvert, Robi Tacutu, Samim Sharifi, R. Teixeira, P. Ghosh, J. Magalhães (2015)
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegansAging Cell, 15
-
( Sousa-Victor P , García-Prat L , Serrano A , Perdiguero E , Muñoz-Cánoves P . Muscle stem cell aging: Regulation and rejuvenation. Trends in Endocrinology & Metabolism. 2016;266:287–96.)
Sousa-Victor P , García-Prat L , Serrano A , Perdiguero E , Muñoz-Cánoves P . Muscle stem cell aging: Regulation and rejuvenation. Trends in Endocrinology & Metabolism. 2016;266:287–96., Sousa-Victor P , García-Prat L , Serrano A , Perdiguero E , Muñoz-Cánoves P . Muscle stem cell aging: Regulation and rejuvenation. Trends in Endocrinology & Metabolism. 2016;266:287–96.
-
( McGee S , Fairlie E , Garnham A , Hargreaves M . Exercise-induced histone modifications in human skeletal muscle. The Journal of Physiology. 2009;587Pt 24:5951–8.19884317)
McGee S , Fairlie E , Garnham A , Hargreaves M . Exercise-induced histone modifications in human skeletal muscle. The Journal of Physiology. 2009;587Pt 24:5951–8.19884317, McGee S , Fairlie E , Garnham A , Hargreaves M . Exercise-induced histone modifications in human skeletal muscle. The Journal of Physiology. 2009;587Pt 24:5951–8.19884317
-
( Feng D , Liu T , Sun Z , Bugge A , Mullican S , Alenghat T , et al A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011;3316022:1315–9.21393543)
Feng D , Liu T , Sun Z , Bugge A , Mullican S , Alenghat T , et al A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011;3316022:1315–9.21393543, Feng D , Liu T , Sun Z , Bugge A , Mullican S , Alenghat T , et al A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011;3316022:1315–9.21393543
-
( Sharma S , Taliyan R , Ramagiri S . Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. Journal of Molecular Neuroscience: MN. 2015;561:1–11.25391764)
Sharma S , Taliyan R , Ramagiri S . Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. Journal of Molecular Neuroscience: MN. 2015;561:1–11.25391764, Sharma S , Taliyan R , Ramagiri S . Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. Journal of Molecular Neuroscience: MN. 2015;561:1–11.25391764
-
( Buford T , Cooke M , Manini T , Leeuwenburgh C , Willoughby D . Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2010;655:532–7.)
Buford T , Cooke M , Manini T , Leeuwenburgh C , Willoughby D . Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2010;655:532–7., Buford T , Cooke M , Manini T , Leeuwenburgh C , Willoughby D . Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2010;655:532–7.
-
( Calvert S , Tacutu R , Sharifi S , Teixeira R , Ghosh P , de Magalhães J . A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell. 2015):n/a-n/a.)
Calvert S , Tacutu R , Sharifi S , Teixeira R , Ghosh P , de Magalhães J . A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell. 2015):n/a-n/a., Calvert S , Tacutu R , Sharifi S , Teixeira R , Ghosh P , de Magalhães J . A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell. 2015):n/a-n/a.
-
( Lu J , McKinsey T , Zhang C-L , Olson E . Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Molecular Cell. 2000;62:233–44.10983972)
Lu J , McKinsey T , Zhang C-L , Olson E . Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Molecular Cell. 2000;62:233–44.10983972, Lu J , McKinsey T , Zhang C-L , Olson E . Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Molecular Cell. 2000;62:233–44.10983972
-
( Roubenoff R , Parise H , Payette H , Abad L , D’Agostino R , Jacques P , et al Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: The Framingham Heart Study. The American Journal of Medicine. 2003;1156:429–35.14563498)
Roubenoff R , Parise H , Payette H , Abad L , D’Agostino R , Jacques P , et al Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: The Framingham Heart Study. The American Journal of Medicine. 2003;1156:429–35.14563498, Roubenoff R , Parise H , Payette H , Abad L , D’Agostino R , Jacques P , et al Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: The Framingham Heart Study. The American Journal of Medicine. 2003;1156:429–35.14563498
-
( Maughan RJ , Watson JS , Weir J . Strength and cross-sectional area of human skeletal muscle. The Journal of Physiology. 1983;3381:37–49.6875963)
Maughan RJ , Watson JS , Weir J . Strength and cross-sectional area of human skeletal muscle. The Journal of Physiology. 1983;3381:37–49.6875963, Maughan RJ , Watson JS , Weir J . Strength and cross-sectional area of human skeletal muscle. The Journal of Physiology. 1983;3381:37–49.6875963
-
( Radák Z , Takahashi R , Kumiyama A , Nakamoto H , Ohno H , Ookawara T , et al Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Experimental Gerontology. 2002;3712:1423–30.12559411)
Radák Z , Takahashi R , Kumiyama A , Nakamoto H , Ohno H , Ookawara T , et al Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Experimental Gerontology. 2002;3712:1423–30.12559411, Radák Z , Takahashi R , Kumiyama A , Nakamoto H , Ohno H , Ookawara T , et al Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Experimental Gerontology. 2002;3712:1423–30.12559411
-
( Ruiz J , Sui X , Lobelo F , Morrow J , Jackson A , Sjöström M , et al Association between muscular strength and mortality in men: Prospective cohort study. BMJ. 2008;337.)
Ruiz J , Sui X , Lobelo F , Morrow J , Jackson A , Sjöström M , et al Association between muscular strength and mortality in men: Prospective cohort study. BMJ. 2008;337., Ruiz J , Sui X , Lobelo F , Morrow J , Jackson A , Sjöström M , et al Association between muscular strength and mortality in men: Prospective cohort study. BMJ. 2008;337.
-
( Rooyackers OE , Adey DB , Ades PA , Nair KS . Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 1996;9326:15364–9.8986817)
Rooyackers OE , Adey DB , Ades PA , Nair KS . Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 1996;9326:15364–9.8986817, Rooyackers OE , Adey DB , Ades PA , Nair KS . Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 1996;9326:15364–9.8986817
-
Scott Ebert, Michael Dyle, S. Bullard, Jason Dierdorff, D. Murry, Daniel Fox, K. Bongers, V. Lira, D. Meyerholz, J. Talley, C. Adams (2015)
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and AtrophyThe Journal of Biological Chemistry, 290
-
Shali Chen, B. Feng, Biju George, R. Chakrabarti, Megan Chen, S. Chakrabarti (2010)
Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells.American journal of physiology. Endocrinology and metabolism, 298 1
-
E. Castillo, D. Goodman-gruen, D. Kritz-Silverstein, D. Morton, D. Wingard, E. Barrett-Connor (2003)
Sarcopenia in elderly men and women: the Rancho Bernardo study.American journal of preventive medicine, 25 3
-
J. Heredia, Lata Mukundan, Francis Chen, Alisa Mueller, R. Deo, R. Locksley, T. Rando, A. Chawla (2013)
Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle RegenerationCell, 153
-
S. Iezzi, G. Cossu, C. Nervi, V. Sartorelli, P. Puri (2002)
Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylasesProceedings of the National Academy of Sciences of the United States of America, 99
-
( Hinken A , Powers J , Luo G , Holt J , Billin A , Russell A . Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells. Aging Cell. 2016:n/a-n/a.)
Hinken A , Powers J , Luo G , Holt J , Billin A , Russell A . Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells. Aging Cell. 2016:n/a-n/a., Hinken A , Powers J , Luo G , Holt J , Billin A , Russell A . Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells. Aging Cell. 2016:n/a-n/a.
-
(2003)
Gut microbiota for healthy aging Aging and Body Composition Study -
Jian-Fu Chen, Elizabeth Mandel, J. Thomson, Qiulian Wu, E. Thomas, Callis, Scott Hammond, Frank Conlon, Da-Zhi Wang (2006)
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiationNature Genetics, 38
-
W. Kohrt, M. Malley, G. Dalsky, J. Holloszy (1992)
Body composition of healthy sedentary and trained, young and older men and women.Medicine and science in sports and exercise, 24 7
-
( Trendelenburg AU , Meyer A , Jacobi C , Feige J , Glass D . TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skeletal Muscle. 2012;21.)
Trendelenburg AU , Meyer A , Jacobi C , Feige J , Glass D . TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skeletal Muscle. 2012;21., Trendelenburg AU , Meyer A , Jacobi C , Feige J , Glass D . TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skeletal Muscle. 2012;21.
-
( Carmelli D , Reed T . Stability and change in genetic and environmental influences on hand-grip strength in older male twins. Journal of Applied Physiology. 2000;895:1879–83.11053339)
Carmelli D , Reed T . Stability and change in genetic and environmental influences on hand-grip strength in older male twins. Journal of Applied Physiology. 2000;895:1879–83.11053339, Carmelli D , Reed T . Stability and change in genetic and environmental influences on hand-grip strength in older male twins. Journal of Applied Physiology. 2000;895:1879–83.11053339
-
( Srikanthan P , Karlamangla A . Muscle mass index as a predictor of longevity in older adults. The American Journal of Medicine. 2014;1276:547–53.24561114)
Srikanthan P , Karlamangla A . Muscle mass index as a predictor of longevity in older adults. The American Journal of Medicine. 2014;1276:547–53.24561114, Srikanthan P , Karlamangla A . Muscle mass index as a predictor of longevity in older adults. The American Journal of Medicine. 2014;1276:547–53.24561114
-
( Vinciguerra M , Fulco M , Ladurner A , Sartorelli V , Rosenthal N . SirT1 in muscle physiology and disease: Lessons from mouse models. Disease Models & Mechanisms. 2010;35-6:298–303.20354108)
Vinciguerra M , Fulco M , Ladurner A , Sartorelli V , Rosenthal N . SirT1 in muscle physiology and disease: Lessons from mouse models. Disease Models & Mechanisms. 2010;35-6:298–303.20354108, Vinciguerra M , Fulco M , Ladurner A , Sartorelli V , Rosenthal N . SirT1 in muscle physiology and disease: Lessons from mouse models. Disease Models & Mechanisms. 2010;35-6:298–303.20354108
-
( Phillips T , Leeuwenburgh C . Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB Journal. 2005;196:668–70.15665035)
Phillips T , Leeuwenburgh C . Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB Journal. 2005;196:668–70.15665035, Phillips T , Leeuwenburgh C . Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB Journal. 2005;196:668–70.15665035
-
( Owen D , Ornaghi P , Yang JC , Lowe N , Evans P , Ballario P , et al The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5The EMBO Journal 2000;1922:6141–9.)
Owen D , Ornaghi P , Yang JC , Lowe N , Evans P , Ballario P , et al The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5The EMBO Journal 2000;1922:6141–9., Owen D , Ornaghi P , Yang JC , Lowe N , Evans P , Ballario P , et al The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5The EMBO Journal 2000;1922:6141–9.
-
M. Altun, Henrike Besche, H. Overkleeft, R. Piccirillo, Mariola Edelmann, B. Kessler, A. Goldberg, B. Ulfhake (2010)
Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway*The Journal of Biological Chemistry, 285
-
Sarah Senf, Pooja Sandesara, Andrew Judge (2011)
p300 acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscleThe FASEB Journal, 25
-
( Baumgartner R , Koehler K , Gallagher D , Romero L , Heymsfield S , Ross R , et al Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology. 1998;1478:755–63.9554417)
Baumgartner R , Koehler K , Gallagher D , Romero L , Heymsfield S , Ross R , et al Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology. 1998;1478:755–63.9554417, Baumgartner R , Koehler K , Gallagher D , Romero L , Heymsfield S , Ross R , et al Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology. 1998;1478:755–63.9554417
-
( Nguyen-Tran D-H , Hait N , Sperber H , Qi J , Fischer K , Ieronimakis N , et al Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Disease Models and Mechanisms. 2014;71:41–54.24077965)
Nguyen-Tran D-H , Hait N , Sperber H , Qi J , Fischer K , Ieronimakis N , et al Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Disease Models and Mechanisms. 2014;71:41–54.24077965, Nguyen-Tran D-H , Hait N , Sperber H , Qi J , Fischer K , Ieronimakis N , et al Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. Disease Models and Mechanisms. 2014;71:41–54.24077965
-
( Karlsson J , Komi PV , Viitasalo JH . Muscle strength and muscle characteristics in monozygous and dizygous twins. Acta physiologica Scandinavica. 1979;1063:319–25.574351)
Karlsson J , Komi PV , Viitasalo JH . Muscle strength and muscle characteristics in monozygous and dizygous twins. Acta physiologica Scandinavica. 1979;1063:319–25.574351, Karlsson J , Komi PV , Viitasalo JH . Muscle strength and muscle characteristics in monozygous and dizygous twins. Acta physiologica Scandinavica. 1979;1063:319–25.574351
-
A. Newman, C. Haggerty, B. Goodpaster, T. Harris, S. Kritchevsky, M. Nevitt, T. Miles, M. Visser, The G (2003)
Strength and Muscle Quality in a Well‐Functioning Cohort of Older Adults: The Health, Aging and Body Composition StudyJournal of the American Geriatrics Society, 51
-
K. Tiainen, S. Sipilä, M. Alen, E. Heikkinen, J. Kaprio, M. Koskenvuo, A. Tolvanen, S. Pajala, T. Rantanen (2005)
Shared genetic and environmental effects on strength and power in older female twins.Medicine and science in sports and exercise, 37 1
-
( Duby R , Olson E . Signaling pathways in skeletal muscle remodeling. Annual Review of Biochemistry. 2006;751:19–37.)
Duby R , Olson E . Signaling pathways in skeletal muscle remodeling. Annual Review of Biochemistry. 2006;751:19–37., Duby R , Olson E . Signaling pathways in skeletal muscle remodeling. Annual Review of Biochemistry. 2006;751:19–37.
-
( Clark B , Manini T . Sarcopenia=/=dynapenia. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2008;638:829–34.)
Clark B , Manini T . Sarcopenia=/=dynapenia. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2008;638:829–34., Clark B , Manini T . Sarcopenia=/=dynapenia. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences. 2008;638:829–34.
-
K. Dietz, P. Casaccia (2010)
HDAC inhibitors and neurodegeneration: at the edge between protection and damage.Pharmacological research, 62 1
-
( Tiainen K , Sipilä S , Alén M , Heikkinen E , Kaprio J , Koskenvuo M , et al Shared genetic and environmental effects on strength and power in older female twins. Medicine and Science in Sports and Exercise. 2005;371:72–8.15632671)
Tiainen K , Sipilä S , Alén M , Heikkinen E , Kaprio J , Koskenvuo M , et al Shared genetic and environmental effects on strength and power in older female twins. Medicine and Science in Sports and Exercise. 2005;371:72–8.15632671, Tiainen K , Sipilä S , Alén M , Heikkinen E , Kaprio J , Koskenvuo M , et al Shared genetic and environmental effects on strength and power in older female twins. Medicine and Science in Sports and Exercise. 2005;371:72–8.15632671
-
Y. Jang, M. Lustgarten, Yuhong Liu, F. Muller, A. Bhattacharya, Hanyu Liang, A. Salmon, S. Brooks, L. Larkin, C. Hayworth, A. Richardson, H. Remmen (2010)
Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degenerationThe FASEB Journal, 24
-
R. Koopman, L. Verdijk, R. Manders, A. Gijsen, M. Gorselink, E. Pijpers, A. Wagenmakers, L. Loon (2006)
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.The American journal of clinical nutrition, 84 3
-
( Backs J , Backs T , Bezprozvannaya S , McKinsey T , Olson E . Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4. Mol Cell Biol. 2008;2810:3437–45.18332106)
Backs J , Backs T , Bezprozvannaya S , McKinsey T , Olson E . Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4. Mol Cell Biol. 2008;2810:3437–45.18332106, Backs J , Backs T , Bezprozvannaya S , McKinsey T , Olson E . Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4. Mol Cell Biol. 2008;2810:3437–45.18332106
-
Andrew Williams, Gregorio Valdez, V. Moresi, X. Qi, John McAnally, J. Elliott, R. Bassel-Duby, J. Sanes, E. Olson (2009)
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in MiceScience, 326
-
Pedro Sousa‐Victor, Laura Garcia-Prat, A. Serrano, Eusebio Perdiguero, P. Muñoz-Cánoves (2015)
Muscle stem cell aging: regulation and rejuvenationTrends in Endocrinology & Metabolism, 26
-
S. McGee, E. Fairlie, A. Garnham, M. Hargreaves (2009)
Exercise‐induced histone modifications in human skeletal muscleThe Journal of Physiology, 587
-
Joo-Yong Lee, H. Koga, Y. Kawaguchi, W. Tang, E. Wong, Ya‐sheng Gao, U. Pandey, Susmita Kaushik, Emily Tresse, Jianrong Lu, J. Taylor, A. Cuervo, T. Yao (2010)
HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagyThe EMBO Journal, 29
-
( Berdeaux R , Goebel N , Banaszynski L , Takemori H , Wandless T , Shelton D , et al SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nature Medicine. 2007;135:597–603.)
Berdeaux R , Goebel N , Banaszynski L , Takemori H , Wandless T , Shelton D , et al SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nature Medicine. 2007;135:597–603., Berdeaux R , Goebel N , Banaszynski L , Takemori H , Wandless T , Shelton D , et al SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nature Medicine. 2007;135:597–603.
-
( Gao Z , Yin J , Zhang J , Ward R , Martin R , Lefevre M , et al Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes. 2009;587.)
Gao Z , Yin J , Zhang J , Ward R , Martin R , Lefevre M , et al Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes. 2009;587., Gao Z , Yin J , Zhang J , Ward R , Martin R , Lefevre M , et al Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes. 2009;587.
-
M. D'Andrea, A. Pisaniello, C. Serra, M. Senni, L. Castaldi, M. Molinaro, M. Bouché (2006)
Protein kinase C theta co‐operates with calcineurin in the activation of slow muscle genes in cultured myogenic cellsJournal of Cellular Physiology, 207
-
Matthew McBrian, Iman Behbahan, R. Ferrari, Trent Su, Ta-Wei Huang, Kunwu Li, C. Hong, H. Christofk, M. Vogelauer, D. Seligson, S. Kurdistani (2013)
Histone acetylation regulates intracellular pH.Molecular cell, 49 2
-
( Gallagher D , Visser M , De Meersman RE , Sepúlveda D , Baumgartner RN , Pierson RN , et al Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. Journal of Applied Physiology (Bethesda, Md: 1985). 1997;831:229–39.)
Gallagher D , Visser M , De Meersman RE , Sepúlveda D , Baumgartner RN , Pierson RN , et al Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. Journal of Applied Physiology (Bethesda, Md: 1985). 1997;831:229–39., Gallagher D , Visser M , De Meersman RE , Sepúlveda D , Baumgartner RN , Pierson RN , et al Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. Journal of Applied Physiology (Bethesda, Md: 1985). 1997;831:229–39.
-
( Altun M , Besche H , Overkleeft H , Piccirillo R , Edelmann M , Kessler B , et al Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. Journal of Biological Chemistry. 2010;28551:39597–608.20940294)
Altun M , Besche H , Overkleeft H , Piccirillo R , Edelmann M , Kessler B , et al Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. Journal of Biological Chemistry. 2010;28551:39597–608.20940294, Altun M , Besche H , Overkleeft H , Piccirillo R , Edelmann M , Kessler B , et al Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. Journal of Biological Chemistry. 2010;28551:39597–608.20940294
-
( Iezzi S , Cossu G , Nervi C , Sartorelli V , Puri P . Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc Natl Acad Sci U S A. 2002;9911:7757–62.12032356)
Iezzi S , Cossu G , Nervi C , Sartorelli V , Puri P . Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc Natl Acad Sci U S A. 2002;9911:7757–62.12032356, Iezzi S , Cossu G , Nervi C , Sartorelli V , Puri P . Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc Natl Acad Sci U S A. 2002;9911:7757–62.12032356
-
Z. Radák, R. Takahashi, Atsushi Kumiyama, H. Nakamoto, H. Ohno, T. Ookawara, S. Goto (2002)
Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendonExperimental Gerontology, 37
-
( Edström L , Larsson L . Effects of age on contractile and enzyme-histochemical properties of fast- and slow-twitch single motor units in the rat. The Journal of Physiology. 1987;392, 129–45.2965761)
Edström L , Larsson L . Effects of age on contractile and enzyme-histochemical properties of fast- and slow-twitch single motor units in the rat. The Journal of Physiology. 1987;392, 129–45.2965761, Edström L , Larsson L . Effects of age on contractile and enzyme-histochemical properties of fast- and slow-twitch single motor units in the rat. The Journal of Physiology. 1987;392, 129–45.2965761
-
C. Mozzetta, S. Consalvi, V. Saccone, Matthew Tierney, A. Diamantini, Kathryn Mitchell, G. Marazzi, G. Borsellino, L. Battistini, D. Sassoon, A. Sacco, P. Puri (2013)
Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx miceEMBO Molecular Medicine, 5
-
Suryaprakash Raichur, Song Teh, K. Ohwaki, Vidhi Gaur, Y. Long, M. Hargreaves, S. McGee, J. Kusunoki (2012)
Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells.Journal of molecular endocrinology, 49 3
-
M. Campbell, A. McComas, F. Petito (1973)
Physiological changes in ageing musclesJournal of Neurology, Neurosurgery & Psychiatry, 36
-
V. Hughes, R. Roubenoff, M. Wood, W. Frontera, W. Evans, M. Singh (2004)
Anthropometric assessment of 10-y changes in body composition in the elderly.The American journal of clinical nutrition, 80 2
-
Charette (1991)
Muscle hypertrophy response to resistance training in older womenJournal of Applied Physiology (Bethesda, Md: 1985), 70
-
I. Janssen, S. Heymsfield, R. Ross (2002)
Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical DisabilityJournal of the American Geriatrics Society, 50
-
( Dressel U , Bailey P , Wang M , Downes M , Evans R , Muscat G . A Dynamic role for HDAC7 in MEF2-mediated muscle differentiation. Journal of Biological Chemistry. 2001;27620:17007–13.11279209)
Dressel U , Bailey P , Wang M , Downes M , Evans R , Muscat G . A Dynamic role for HDAC7 in MEF2-mediated muscle differentiation. Journal of Biological Chemistry. 2001;27620:17007–13.11279209, Dressel U , Bailey P , Wang M , Downes M , Evans R , Muscat G . A Dynamic role for HDAC7 in MEF2-mediated muscle differentiation. Journal of Biological Chemistry. 2001;27620:17007–13.11279209
-
( Colman R , Anderson R , Johnson S , Kastman E , Kosmatka K , Beasley M , et al Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;3255937:201–4.19590001)
Colman R , Anderson R , Johnson S , Kastman E , Kosmatka K , Beasley M , et al Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;3255937:201–4.19590001, Colman R , Anderson R , Johnson S , Kastman E , Kosmatka K , Beasley M , et al Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;3255937:201–4.19590001
-
( Mihaylova M , Vasquez D , Ravnskjaer K , Denechaud P-D , Yu R , Alvarez J , et al Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011;1454:607–21.21565617)
Mihaylova M , Vasquez D , Ravnskjaer K , Denechaud P-D , Yu R , Alvarez J , et al Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011;1454:607–21.21565617, Mihaylova M , Vasquez D , Ravnskjaer K , Denechaud P-D , Yu R , Alvarez J , et al Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011;1454:607–21.21565617
-
( White T , LeBrasseur N . Myostatin and sarcopenia: Opportunities and challenges - a mini-review. Gerontology. 2014;604:289–93.24457615)
White T , LeBrasseur N . Myostatin and sarcopenia: Opportunities and challenges - a mini-review. Gerontology. 2014;604:289–93.24457615, White T , LeBrasseur N . Myostatin and sarcopenia: Opportunities and challenges - a mini-review. Gerontology. 2014;604:289–93.24457615
-
Amelia Johnston, K. Murphy, Laura Jenkinson, D. Laine, Kerstin Emmrich, P. Faou, R. Weston, K. Jayatilleke, Jessie Schloegel, G. Talbo, J. Casey, Vitalina Levina, W. Wong, H. Dillon, Tushar Sahay, J. Hoogenraad, H. Anderton, Cathrine Hall, P. Schneider, M. Tanzer, M. Foley, A. Scott, P. Gregorevic, Spring Liu, L. Burkly, G. Lynch, J. Silke, N. Hoogenraad (2015)
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs SurvivalCell, 162
-
( Chai RJ , Vukovic J , Dunlop S , Grounds M , Shavlakadze T . Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle. PloS One. 2011;612.)
Chai RJ , Vukovic J , Dunlop S , Grounds M , Shavlakadze T . Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle. PloS One. 2011;612., Chai RJ , Vukovic J , Dunlop S , Grounds M , Shavlakadze T . Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle. PloS One. 2011;612.
- Publisher
- IOS Press
- Copyright
- Copyright © 2016 IOS Press and the authors. All rights reserved
- ISSN
- 2451-9480
- eISSN
- 2451-9502
- DOI
- 10.3233/NHA-160005
- Publisher site
- See Article on Publisher Site
Abstract
BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is associated with muscle weakness, frailty, and the loss of independence in older adults. The mechanisms contributing to sarcopenia are not totally understood, but muscle fiber loss due to apoptosis, reduced stimulation of anabolic pathways, activation of catabolic pathways, denervation, and altered metabolism have been observed in muscle from old rodents and humans.OBJECTIVE: Recently, histone deacetylases (HDACs) have been implicated in muscle atrophy and dysfunction due to denervation, muscular dystrophy, and disuse, and HDACs play key roles in regulating metabolism in skeletal muscle. In this review, we will discuss the role of HDACs in muscle atrophy and the potential of HDAC inhibitors for the treatment of sarcopenia.CONCLUSIONS: Several HDAC isoforms are potential targets for intervention in sarcopenia. Inhibition of HDAC1 prevents muscle atrophy due to nutrient deprivation. HDAC3 regulates metabolism in skeletal muscle and may inhibit oxidative metabolism during aging. HDAC4 and HDAC5 have been implicated in muscle atrophy due to denervation, a process implicated in sarcopenia. HDAC inhibitors are already in use in the clinic, and there is promise in targeting HDACs for the treatment of sarcopenia.
Journal
Nutrition and Healthy Aging – IOS Press
Published: Jan 1, 2016