Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial

Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a... BACKGROUND:Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.OBJECTIVE:This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.METHODS:Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).RESULTS:Body weight decreased similarly (P < 0.001) by ADF (–7.8±1.2%) and CR (–8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased (P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.CONCLUSION:These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition and Healthy Aging IOS Press

Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial

Download PDF
9 pages

Loading next page...
 
/lp/ios-press/effect-of-alternate-day-fasting-on-markers-of-bone-metabolism-an-CeBq7gT0ua
Publisher
IOS Press
Copyright
Copyright © 2017 © 2017 – IOS Press and the authors. All rights reserved
ISSN
2451-9480
eISSN
2451-9502
DOI
10.3233/NHA-170031
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND:Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.OBJECTIVE:This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.METHODS:Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).RESULTS:Body weight decreased similarly (P < 0.001) by ADF (–7.8±1.2%) and CR (–8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased (P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.CONCLUSION:These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.

Journal

Nutrition and Healthy Aging – IOS Press

Published: Jan 1, 2017

There are no references for this article.