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- Publisher
- IOS Press
- Copyright
- Copyright © 2016 IOS Press and the authors. All rights reserved
- ISSN
- 1093-2607
- eISSN
- 1875-869X
- DOI
- 10.3233/HAB-160297
- pmid
- 27792005
- Publisher site
- See Article on Publisher Site
Abstract
BACKGROUND: Multiple sclerosis (MS) as a complex neurologicaldisease can be due to vitamin D deficiency. CYP27B1 is referred to as avitamin D metabolizing enzyme. MATERIALS AND METHODS: This studycompared the expression level of CYP27B1 in Relapsing-Remitting MS (RRMS)patients with normal individuals in Iran. The RNA was extracted from 50 RRMSpatients and 50 normal controls. Quantitative RT-PCR was adopted to measurethe expression level of CYP27B1 gene. RESULTS: The expression levelof CYP27B1gene was significantly lower in the RRMS patients than theirnormal counterparts (P value = 0.04). Also, the RRMS females participating hada significant reduction in CYP27B1 gene expression compared to normalfemales (P-Value = 0.01). In addition, the correlation between CYP27B1expression level, and the risk of Expanded Disability Status Scaleof Kurtzke (EDSS) was not linear. Additionally, there was no significantcorrelation between expression status of CYP27B1gene and duration of thedisease. CONCLUSION: A significant decrease in the expression levelof CYP27A1 in female patients could indicate their greater vulnerability toMS than the male patients.
Journal
Human Antibodies – IOS Press
Published: Jan 1, 2017