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Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment

Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes... 1IntroductionIn 2013, the global burden of diabetes was estimated to be 382 million individuals, increasing to almost 592 million by 2035 [1]. The economic burden of diabetes is also high, in part due to chronic comorbidities such as cardiovascular and renal disease. US healthcare spending because of diabetes and its complications reached almost $306 billion in 2012 [2]. Of note, the aging population, specifically those over 65, are expected to experience the greatest increase in diabetes incidence, with a 134% increase by year 2030 [3]. Although the increased diabetes prevalence in the aged population may be explained partly by reduced all-cause mortality due to the advances of modern medicine, sedentary lifestyle and poor dietary habits are major risk factors for diabetes and are highly associated with the onset and rapid progression of diabetes.The modern food supply has evolved from that of our distant ancestors because of advances in agriculture, technology, and economic interest. Not only has an increased food supply made it easier for individuals in industrialized countries to consume a greater number of calories, but also the nutritional composition of that food supply continues to change. One class of nutrients that is drastically diverging from that of our http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition and Healthy Aging IOS Press

Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment

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References (149)

Publisher
IOS Press
Copyright
Copyright © 2017 IOS Press and the authors. All rights reserved
ISSN
2451-9480
eISSN
2451-9502
DOI
10.3233/NHA-160004
Publisher site
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Abstract

1IntroductionIn 2013, the global burden of diabetes was estimated to be 382 million individuals, increasing to almost 592 million by 2035 [1]. The economic burden of diabetes is also high, in part due to chronic comorbidities such as cardiovascular and renal disease. US healthcare spending because of diabetes and its complications reached almost $306 billion in 2012 [2]. Of note, the aging population, specifically those over 65, are expected to experience the greatest increase in diabetes incidence, with a 134% increase by year 2030 [3]. Although the increased diabetes prevalence in the aged population may be explained partly by reduced all-cause mortality due to the advances of modern medicine, sedentary lifestyle and poor dietary habits are major risk factors for diabetes and are highly associated with the onset and rapid progression of diabetes.The modern food supply has evolved from that of our distant ancestors because of advances in agriculture, technology, and economic interest. Not only has an increased food supply made it easier for individuals in industrialized countries to consume a greater number of calories, but also the nutritional composition of that food supply continues to change. One class of nutrients that is drastically diverging from that of our

Journal

Nutrition and Healthy Aging – IOS Press

Published: Jan 1, 2017

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