Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Scaffidi, I. Schmitz, J. Zha, S. Korsmeyer, P. Krammer, M. Peter (1999)
Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells*The Journal of Biological Chemistry, 274
Feifan Zhou, Sheng Song, Wei Chen, D. Xing (2011)
Immunostimulatory properties of glycated chitosan.Journal of X-ray science and technology, 19 2
Thomas Efferth, Heather Dunstan, Axel Sauerbrey, Hayato Miyachi, Christopher Chitambar (2001)
The anti-malarial artesunate is also active against cancer.International journal of oncology, 18 4
Mary Shawgo, Shary Shelton, J. Robertson (2008)
Caspase-mediated Bak Activation and Cytochrome c Release during Intrinsic Apoptotic Cell Death in Jurkat Cells*Journal of Biological Chemistry, 283
Shasi Kalivendi, S. Kotamraju, Hongtao Zhao, J. Joseph, B. Kalyanaraman (2001)
Doxorubicin-induced Apoptosis Is Associated with Increased Transcription of Endothelial Nitric-oxide SynthaseThe Journal of Biological Chemistry, 276
Sharad Kumar (2007)
Caspase function in programmed cell deathCell Death and Differentiation, 14
J. Walsh, S. Cullen, Clare Sheridan, A. Lüthi, C. Gerner, Seamus Martin (2008)
Executioner caspase-3 and caspase-7 are functionally distinct proteasesProceedings of the National Academy of Sciences, 105
Junmei Hou, Disong Wang, Ruiwen Zhang, Hui Wang (2008)
Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of ActionClinical Cancer Research, 14
T. Efferth, M. Volm (2005)
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.In vivo, 19 1
A. Mercer, J. Maggs, Xiao-Ming Sun, Gerald Cohen, James Chadwick, Paul O’Neill, B. Park (2007)
Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds*Journal of Biological Chemistry, 282
A. Debrabant, M. Joshi, P. Pimenta, D. Dwyer (2004)
Generation of Leishmania donovani axenic amastigotes: their growth and biological characteristics.International journal for parasitology, 34 2
Nancy Thornberry, Y. Lazebnik (1998)
Caspases: enemies within.Science, 281 5381
T. Efferth (2007)
Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to BedsidePlanta Medica, 73
J. Fletcher, S. Meusburger, C. Hawkins, David Riglar, Erinna Lee, W. Fairlie, D. Huang, Jerry Adams (2008)
INAUGURAL ARTICLE by a Recently Elected Academy Member:Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain BaxProceedings of the National Academy of Sciences of the United States of America, 105
Tongsheng Chen, Jinjun Wang, D. Xing, Wei Chen (2007)
Spatio-Temporal Dynamic Analysis of Bid Activation and Apoptosis Induced by Alkaline Condition in Human Lung Adenocarcinoma CellCellular Physiology and Biochemistry, 20
Yun-xia Wu, D. Xing, S. Luo, Yonghong Tang, Qun Chen (2006)
Detection of caspase-3 activation in single cells by fluorescence resonance energy transfer during photodynamic therapy induced apoptosis.Cancer letters, 235 2
J. Willoughby, S. Sundar, M. Cheung, Antony Tin, J. Modiano, G. Firestone (2009)
Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression*Journal of Biological Chemistry, 284
Long-xiang Wang, Tongsheng Chen, J. Qu, Xunbin Wei (2009)
Photobleaching-Based Quantitative Analysis of Fluorescence Resonance Energy Transfer inside Single Living CellJournal of Fluorescence, 20
Hyungjin Kim, Ho-Chou Tu, Decheng Ren, O. Takeuchi, John Jeffers, G. Zambetti, J. Hsieh, E. Cheng (2009)
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Molecular cell, 36 3
A. Pautsch, G. Schulz (1998)
Structure of the outer membrane protein A transmembrane domainNature Structural Biology, 5
Ying-ying Lu, Tongsheng Chen, Jun-le Qu, Wen-liang Pan, Lei Sun, Xun Wei (2009)
Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cellsJournal of Biomedical Science, 16
Lan Zhang, D. Xing, Miaojuan Chen (2008)
BimL displacing Bcl-xL promotes Bax translocation during TNFα-induced apoptosisApoptosis, 13
Tao Chen, Mian Li, Ruiwen Zhang, Hui Wang (2008)
Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapyJournal of Cellular and Molecular Medicine, 13
Yun-xia Wu, D. Xing, Wei Chen (2006)
Single Cell FRET Imaging for Determination of Pathway of Tumor Cell Apoptosis Induced by Photofrin-PDTCell Cycle, 5
S. Ghavami, M. Hashemi, Sudharsana Ande, B. Yeganeh, W. Xiao, M. Eshraghi, C. Bus, K. Kadkhoda, E. Wiechec, A. Halayko, M. Los (2009)
Apoptosis and cancer: mutations within caspase genesJournal of Medical Genetics, 46
Ying-ying Lu, Tongsheng Chen, Xiaopin Wang, Jun-le Qu, Min Chen (2010)
The JNK inhibitor SP600125 enhances dihydroartemisinin‐induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cellsFEBS Letters, 584
Wen-jing Guo, Tongsheng Chen, Xiaopin Wang, Rong Chen (2010)
Taxol induces concentration-dependent apoptotic and paraptosis-like cell death in human lung adenocarcinoma (ASTC-a-1) cells.Journal of X-ray science and technology, 18 3
R. Handrick, T. Ontikatze, K. Bauer, Florian Freier, Amelie Rübel, J. Dürig, C. Belka, V. Jendrossek (2010)
Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic PathwayMolecular Cancer Therapeutics, 9
C. Minichsdorfer, M. Hohenegger (2009)
Autocrine amplification loop in statin‐induced apoptosis of human melanoma cellsBritish Journal of Pharmacology, 157
Ye Ji, Yi-Cai Zhang, L. Pei, Li Shi, Jing-long Yan, Xue Ma (2011)
Anti-tumor effects of dihydroartemisinin on human osteosarcomaMolecular and Cellular Biochemistry, 351
K. Takemoto, T. Nagai, A. Miyawaki, M. Miura (2003)
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effectsThe Journal of Cell Biology, 160
R. Onuki, A. Nagasaki, H. Kawasaki, T. Baba, T. Uyeda, K. Taira (2002)
Confirmation by FRET in individual living cells of the absence of significant amyloid β-mediated caspase 8 activationProceedings of the National Academy of Sciences of the United States of America, 99
Artemisinin (ARTE), an antimalarial phytochemical component from the sweet wormwood plant, has been shown a potential anticancer activity by inducing cell apoptosis. The aim of this report is to explore the mechanism of ARTE-induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis. Cell counting kit (CCK-8) assay showed that ARTE induced cytotoxcity in a dose- and time-dependent manner. Confocal microscopy fluorescence imaging of cells stained with Hoechst 33258 and flow cytometry (FCM) analysis of cells stained with Annexin V-FITC/propidium iodide (PI) showed that ARTE induced reactive oxygen species (ROS)-dependent apoptosis. Confocal fluorescence resonance energy transfer (FRET) imaging of single living cells expressing SCAT3, SCAT9 or CFP-Bid-YFP and fluorometic substrate assay showed that ARTE induced the activation of caspase-3, -8 and -9. Moreover, inhibition of caspase-8 or -9 completely blocked ARTE-induced apoptosis which was only partially attenuated by caspase-3 inhibitor. Interestingly, silencing Bax and Bak by RNA interference (RNAi) did not attenuate ARTE-induced apoptosis. Collectively, ARTE induces caspase-dependent but Bax/Bak-independent apoptosis in ASTC-a-1 cells.
Journal of X-Ray Science and Technology – IOS Press
Published: Jan 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.