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SESSION 2 : INFECTIOUS DISEASES Human hyperimmune IgG from immunized. plasma donors for treatment and prevention of infection with multi-drug resistant Staphylococcus aureus A. Fattom. L. Basham, S. Shepherd, J. Sarwar, A Ortioz, L. Fries, and R Naso W. W.Karakawa Bacterial Pathogenesis Laboratory. NABL Rockville. MD. USA The emergence and rapid spread in hospitals of multidrug resistant bacterial infections such as vancomycin resistant enterococci, methicillin resistant staphylococci and penicillin resistant pneumococci, have drawn attention to the need for alternative therapies, including immunotherapies, to combat these. Capsular polysaccharide (CP) vaccines were developed and proved to be effective in preventing some bacterial infections including pneumococci and meningococci. However, active immunization of several at-risk populations is impractical. Active immunization requires both immuno competance and a window of time, from a few days to a few weeks, for the body to mount an appropriate immune response. Groups such as trauma patients, low birthweight neonates, patients on chemotherapy; and many surgical patients are at high risk for infection and either have compromised immune systems, or do not have enough time to mount an effective immune response to active immunization before the onset of infection. For these indiciduals, passive immunization in the form of
Human Antibodies – IOS Press
Published: Jan 1, 1996
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