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Ultrasonic neuromodulation

Ultrasonic neuromodulation Ultrasonic waves can be non-invasively steered and focused into mm-scale regions across the human body and brain, and their application in generating controlled artificial modulation of neuronal activity could therefore potentially have profound implications for neural science and engineering. Ultrasonic neuro-modulation phenomena were experimentally observed and studied for nearly a century, with recent discoveries on direct neural excitation and suppression sparking a new wave of investigations in models ranging from rodents to humans. In this paper we review the physics, engineering and scientific aspects of ultrasonic fields, their control in both space and time, and their effect on neuronal activity, including a survey of both the field’s foundational history and of recent findings. We describe key constraints encountered in this field, as well as key engineering systems developed to surmount them. In closing, the state of the art is discussed, with an emphasis on emerging research and clinical directions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neural Engineering IOP Publishing

Ultrasonic neuromodulation

Journal of Neural Engineering , Volume 13 (3): 18 – Jun 1, 2016

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References (112)

Copyright
Copyright © 2016 IOP Publishing Ltd
ISSN
1741-2560
eISSN
1741-2552
DOI
10.1088/1741-2560/13/3/031003
pmid
27153566
Publisher site
See Article on Publisher Site

Abstract

Ultrasonic waves can be non-invasively steered and focused into mm-scale regions across the human body and brain, and their application in generating controlled artificial modulation of neuronal activity could therefore potentially have profound implications for neural science and engineering. Ultrasonic neuro-modulation phenomena were experimentally observed and studied for nearly a century, with recent discoveries on direct neural excitation and suppression sparking a new wave of investigations in models ranging from rodents to humans. In this paper we review the physics, engineering and scientific aspects of ultrasonic fields, their control in both space and time, and their effect on neuronal activity, including a survey of both the field’s foundational history and of recent findings. We describe key constraints encountered in this field, as well as key engineering systems developed to surmount them. In closing, the state of the art is discussed, with an emphasis on emerging research and clinical directions.

Journal

Journal of Neural EngineeringIOP Publishing

Published: Jun 1, 2016

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