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J. Jung, S. Jin (2021)
Microneedle for transdermal drug delivery: current trends and fabricationJournal of Pharmaceutical Investigation, 51
S. Furse, A. Kroon (2015)
Phosphatidylcholine’s functions beyond that of a membrane brickMolecular Membrane Biology, 32
Liabeuf (2014)
Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French national pharmacovigilance databaseClin. Interv. Aging, 9
Eshant Bhatia, R. Banerjee (2020)
Hybrid silver-gold nanoparticles suppress drug resistant polymicrobial biofilm formation and intracellular infection.Journal of materials chemistry. B
(2015)
A I 2015 Phosphatidylcholine’s functions beyond that of a membrane brickMol
P. Ferrari, A. Nicolini, M. Manca, G. Rossi, L. Anselmi, M. Conte, A. Carpi, F. Bonino (2012)
Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 66 6
A. Ali, A. Hassan, Essam Eissa, Heba Aboud (2021)
Response Surface Optimization of Ultra-Elastic Nanovesicles Loaded with Deflazacort Tailored for Transdermal Delivery: Accentuated Bioavailability and Anti-Inflammatory EfficacyInternational Journal of Nanomedicine, 16
T. Nguyen, Yujeong Oh, Yun-Seo Kim, Yura Shin, Seung-ki Baek, Jung-Hwan Park (2020)
Progress in microneedle array patch (MAP) for vaccine deliveryHuman Vaccines & Immunotherapeutics, 17
Shruti Guhasarkar, P. More, R. Banerjee (2017)
Urothelium‐adherent, ion‐triggered liposome‐in‐gel system as a platform for intravesical drug deliveryJournal of Controlled Release, 245
R. Jeevan, R. Venkat, Mansoor Khan, Kunta, Goskonda, Harry Brotherton, Indra Reddy (1997)
Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin.Journal of pharmaceutical sciences, 86 12
Delly Ramadon, Maelíosa McCrudden, A. Courtenay, R. Donnelly (2021)
Enhancement strategies for transdermal drug delivery systems: current trends and applicationsDrug Delivery and Translational Research, 12
S. Lale, Aswathy G, A. Aravind, D. Kumar, V. Koul (2014)
AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy.Biomacromolecules, 15 5
J. Pardeike, A. Hommoss, R. Müller (2009)
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.International journal of pharmaceutics, 366 1-2
B. Koletzko, K. Godfrey, L. Poston, H. Szajewska, J. Goudoever, M. Waard, B. Brands, R. Grivell, Andrea Deussen, J. Dodd, B. Patro-Gołąb, B. Zalewski (2019)
Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project RecommendationsAnnals of Nutrition and Metabolism, 74
Liping Chen, Lina Ma, Shufang Yang, Xiaowen Wu, X. Dai, Shifeng Wang, Xinyuan Shi (2019)
A multiscale study of the penetration-enhancing mechanism of mentholJournal of Traditional Chinese Medical Sciences
Eman El-leithy, H. Abdel-Bar, Raghda el-Moneum (2018)
Validation of High Performance Liquid Chromatographic Method for Folic Acid Assay
S. Liabeuf, V. Gras, J. Moragny, M. Laroche, M. Andréjak
Clinical Interventions in Aging Dovepress on Behalf of the French National Network of Pharmacovigilance Centers
Naresh Modepalli, H. Shivakumar, Maelíosa McCrudden, Ryan Donnelly, A. Banga, S. Murthy (2016)
Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety.Journal of pharmaceutical sciences, 105 3
Vahid Alimardani, S. Abolmaali, G. Yousefi, Zahra Rahiminezhad, M. Abedi, A. Tamaddon, S. Ahadian (2021)
Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of TherapeuticsJournal of Clinical Medicine, 10
Available at: www.cdc.gov/nutrition/micronutrientmalnutrition/micronutrients/index.html)
Zoe Tolkien, L. Stecher, A. Mander, Dora Pereira, J. Powell (2015)
Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-Effects in Adults: A Systematic Review and Meta-AnalysisPLoS ONE, 10
Rebeca Peñalva, I. Esparza, M. Agüeros, C. González-Navarro, C. González-Ferrero, J. Irache (2015)
Casein nanoparticles as carriers for the oral delivery of folic acidFood Hydrocolloids, 44
M. Kapoor, A. D'Souza, Noorjahan Aibani, S. Nair, Puja Sandbhor, D. Kumari, R. Banerjee (2018)
Stable Liposome in Cosmetic Platforms for Transdermal Folic acid delivery for fortification and treatment of micronutrient deficienciesScientific Reports, 8
F. Marangoni, I. Cetin, E. Verduci, G. Canzone, M. Giovannini, P. Scollo, G. Corsello, A. Poli (2016)
Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus DocumentNutrients, 8
Abd (2016)
Skin models for the testing of transdermal drugsClin. Pharmacol.: Adv. Appl., 8
S. Dugam, R. Tade, Rani Dhole, S. Nangare (2021)
Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectivesFuture Journal of Pharmaceutical Sciences, 7
Noriyuki Uchida, M. Yanagi, H. Hamada (2021)
Physical Enhancement? Nanocarrier? Current Progress in Transdermal Drug DeliveryNanomaterials, 11
M. Kapoor, Shruti Guhasarkar, R. Banerjee (2017)
Stratum corneum modulation by chemical enhancers and lipid nanostructures: implications for transdermal drug delivery.Therapeutic delivery, 8 8
Douglas Kalman, S. Feldman, Adam Samson, D. Krieger
Clinical Pharmacology: Advances and Applications Dovepress
Lalitkumar Vora, Kurtis Moffatt, I. Tekko, Alejandro Paredes, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Ke Peng, Raghu Thakur, R. Donnelly (2020)
Microneedle array systems for long-acting drug delivery.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
A. Dugdale (2006)
Predicting iron and folate deficiency anaemias from standard blood testing: the mechanism and implications for clinical medicine and public health in developing countriesTheoretical Biology & Medical Modelling, 3
Naresh Modepalli, S. Jo, M. Repka, S. Murthy (2013)
Microporation and ‘Iron’tophoresis for Treating Iron Deficiency AnemiaPharmaceutical Research, 30
Rebeca Peñalva, I. Esparza, C. González-Navarro, G. Quincoces, I. Peñuelas, J. Irache (2015)
Zein nanoparticles for oral folic acid deliveryJournal of Drug Delivery Science and Technology, 30
Adequate micronutrient availability is particularly important in women, children and infants. Micronutrient deficiencies are the major cause of maternal and neonatal morbidity. To overcome this, WHO recommends the use of folic acid and iron supplements for reducing anaemia and improving the health of the mother and infants. Oral intake of supplements for nutritional deficiencies are associated with gastric irritation, nausea, constipation and non-patient compliance due to associated taste. In case of absorption deficiency nutrients administered orally pass-through digestive tract unabsorbed. In the present study, we propose transdermal delivery of nutraceuticals to avoid the limitations associated with oral intake. Transdermal delivery has limited use because of the closely packed barrier of the stratum corneum that limits the permeability of molecules across skin. Here, we have used biomimetic nanovesicles impregnated in transdermal patches for delivery of folic acid and iron. Nanovesicles are prepared using an abundant component of cell membrane, phosphatidyl choline and a permeation enhancer. Further these nanovesicles are impregnated onto polyacrylate based transdermal patch. In vitro studies have shown the ability of nanovesicles to fluidise skin lipids and penetrate into deeper skin. In vivo application of transdermal patches gradually increased the systemic concentration of nutraceuticals. Post application of the patch, five-fold increase in plasma folic acid concentration and 1.5-fold increase in plasma iron concertation was achieved in 6 h. Developed nanovesicles were compatible with keratinocytes and fibroblasts as tested in vitro and have the potential to enhance the cellular uptake of molecules. Skin irritation studies on human volunteers have confirmed the safety of nutraceutical loaded nanovesicles. Thus, the developed nutraceutical loaded transdermal patches provide a potential, easy to use platform for micronutrient delivery in infants and mothers.
Biomedical Materials – IOP Publishing
Published: Jul 1, 2022
Keywords: drug delivery; nutraceuticals; transdermal delivery; nanomedicine; nanovesicles
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