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Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature

Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature Hindawi Publishing Corporation Sarcoma Volume 2006, Article ID 52140, Pages 1–3 DOI 10.1155/SRCM/2006/52140 Case Report Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature 1 2 3 4 1 Sakeer Hussain, Anil Nanda, Marjorie Fowler, Federico L. Ampil, and Gary V. Burton Department of Medicine, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Neurosurgery, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Pathology, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Radiology, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Received 29 June 2006; Revised 13 October 2006; Accepted 13 October 2006 A 26-year old man presented with a 3-month history of a progressively enlarging palpable parieto-occipital mass. A CT scan indi- cated the lesion arose from the dura with bony destruction. A stealth assisted craniotomy was performed with the provisional diag- nosis of osteoblastic meningioma. Further histopathologic analysis of the intracranial mass was consistent with leiomyosarcoma. Staging evaluation, including CT and PET scans, demonstrated no other sites of disease. Despite complete surgical resection and radiotherapy to the resection site, the disease recurred locally and systematically 5 months later. Primary intracranial mesenchy- mal tumors are rare and few cases have been previously reported. Outcomes have been universally poor and current therapeutic approaches appear to have only limited benefit. Copyright © 2006 Sakeer Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION ment. There was no history of smoking, IV drug abuse, or sexual promiscuity. Physical examination was remarkable for Intracranial neoplasms of mesenchymal origin are uncom- a palpable 5 cm, fixed, nontender mass over the right parieto- mon. The majority of these tumors represent metastatic dis- occipital region. Complete blood counts and metabolic panel ease from other primary sites. Primary intracranial soft tis- were normal. Viral serology was negative for both human im- sue sarcomas can, however, arise from mesenchymal cells mune deficiency virus (HIV) and Epstein-Barr virus (EBV). of the dura matter or the cerebral blood vessels. These tu- A CT scan of the brain demonstrated a large highly vascu- mors often mimic meningioma on preoperative MRI and, al- lar soft tissue mass involving the meninges with invasion of though rare, should be included in the differential diagnosis the parietal bone and displacement of the brain parenchyma of dural-based lesions. Immunohistochemical stains can help (Figure 1). A clinical diagnosis of osteoblastic meningioma distinguishing these tumors from meningiomas. Postopera- was made. The patient underwent an uncomplicated stealth tive radiation and chemotherapy should be considered, how- assisted craniotomy with cranioplasty and gross microsur- ever, the prognosis has been universally poor. We describe the gical resection of the tumor. The tumor involved the dura course of a patient with a primary intracranial leiomyosar- mater and had eroded through the bony skull. The surgical coma and review the literature. margins were negative. The histologic examination demon- strated a malignant spindle cell neoplasm with immunos- tains positive for smooth muscle actin and negative for ep- CASE HISTORY ithelial membrane antigen (Figure 2). Pathologic interpreta- A 26-year old previously healthy male presented with a 3 tion was a malignant spindle cell neoplasm consistent with month history of progressively enlarging parieto-occipital high grade leiomyosarcoma with myxoid and epitheloid ar- mass. There were no constitutional or neurological symp- eas. Staging CT scan of the chest, abdomen and pelvis and toms and no symptoms suggestive of other sites of involve- PET scan were negative for other sites of involvement. The 2 Sarcoma (a) [PH] Figure 1: CT scan of the head shows a large vascular soft tissue mass involving the meninges and invasion of right parietal bone. patient received radiation therapy consisting of 61.8Gy in 34 fractions using involved field (tumor bed) megavoltage irra- diation. Adjuvant chemotherapy was declined by the patient. Five months following the surgery the patient developed pain in the right hip. An MRI of the right hip showed hetero- (b) geneous marrow replacement in the right ischium extend- ing to the acetabular marrow, with extraosseous soft tissue Figure 2: (a) Malignant spindle cells, pleomorphism, and high nu- component and small ipsilateral joint effusion. A CT scan cleocytoplasmic ratio. (b) Immunostain positive for smooth muscle showed multiple lung lesions and a 2.5 cm liver lesion. An actin. MRI of the brain revealed a suspicious small residual area at the parieto-occipital extradural space. Fine needle aspiration of the lung mass was performed and cytology was consistent with leiomyosarcoma. The patient initially declined systemic The association of these neoplasms with Epstein-Barr virus chemotherapy, but subsequently received liposomal doxoru- infection and AIDS is well documented in the literature bicin without response. He died 7 months after the initial [5, 6]. Our patient, however, had negative serology for both diagnosis. HIV and EBV infections. Radiation exposure has also been associated with an increased incidence of various soft tis- sue sarcomas. Intracranial leiomyosarcoma was reported 23 DISCUSSION years after radiation treatment for a pituitary adenoma [7]. Soft tissue sarcomas are rare tumors and account for only one Our review of primary intracranial myomatous tumors percent of all cancers [1]. Most intracranial soft tissue sarco- found that only one out of 29 reported cases demonstrated mas represent metastatic disease. Primary intracranial sarco- smooth muscle differentiation. The other cases were pure mas are extremely rare [2]. Intracranial sarcomas appear to mesenchymal or mixed neural and mesenchymal tumors originate from leptomeningeal lining and usually have du- showing skeletal muscle differentiation. Tumors with rhab- ral attachment [3]. Pleuripotent mesenchymal stem cells in domyomatous elements were more common than tumors the dura are probably the cells of origin. Intracerebral sar- containing leiomyosarcomatous characteristics [8]. comas may also arise from cerebral blood vessel epithelium In another study of 3829 patients with soft tissue sar- [4]. These tumors may also originate in the blood vessels out- coma, 21 patients presented with and 19 patients subse- side the dural surface and extend to the skull and meninges. quently developed brain metastases. In this study the most There was no definite evidence to confirm the origin of tu- frequent tumor type with metastatic brain involvement was mor in this case but involvement of the dura with invasion of leiomyosarcoma [9]. Leiomyosarcomas, however, tend to ex- the skull suggests a dural origin. hibit hematogenous spread to lung prior to the appearance An increased incidence of leiomyoma and leiomyosar- of brain metastases and, the metastasis usually involves brain coma has been observed in immunocompromised patients. parenchyma [9, 10]. Sakeer Hussain et al 3 The diagnosis of leiomyosarcoma is confirmed by ul- [9] Espat NJ, Bilsky M, Lewis JJ, Leung D, Brennan MF. Soft tis- sue sarcoma brain metastases: prevalence in a cohort of 3829 trastructural features of smooth muscle cells and immuno- patients. Cancer. 2002;94(10):2706–2711. histochemistry. The tumor cells are elongated with taper- [10] Haykal HA, Wang AM, Zamani A. Leiomyosarcoma metastatic ing cytoplasmic processes with elongated, convoluted nu- to the brain: CT features and review. American Journal of Neu- clei, pinocytic vesicles, and basement membrane material roradiology. 1987;8(5):911–912. around the cytoplasmic membrane. The differential diag- [11] Louis DN, Richardson EP Jr, Dickersin GR, Petrucci DA, noses, which include malignant astrocytoma, malignant fi- Rosenberg AE, Ojemann RG. Primary intracranial leiomyo- brous histocytoma, and meningioma, were excluded by im- sarcoma. Case report. Journal of Neurosurgery. 1989;71(2): munohistochemical testing. Our patient’s tumor was nega- 279–282. tive for S-100 protein and epithelial membrane antigen and positive for smooth muscle actin and cytokeratin staining. Although the pathologic and radiographic examination indicated a primary intracranial leiomyosarcoma in our pa- tient, another primary site could not be excluded with com- plete certainty. Within the limits of CT scan and other imag- ing modalities, the evaluation and the clinical course of our patient were consistent with a primary intracranial location. The prognosis for primary intracranial leiomyosarcoma is poor with the longest reported survival being 32 months [9, 11]. Patientsurvivalisprobablylimited by the difficulty in obtaining adequate surgical margins and an adequate ra- diation therapy dose to the intracranial location. Intracranial and meningeal tumor spread may also limit the benefits of systemic adjuvant chemotherapy. Despite these limitations, treatment should probably include aggressive application of multimodality therapy. A primary intracranial tumor of mesodermal origin is rare and the majority of these tumors are rhabdomyosar- coma. Leiomyosarcomas may mimic meningiomas on pre- operative MRI and, although extremely rare, must be in- cluded in the differential diagnosis of dural-based lesions REFERENCES [1] Weitz J, Antonescu CR, Brennan MF. Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time. Journal of Clinical Oncology. 2003;21(14):2719– [2] Paulus W, Slowik F, Jellinger K. Primary intracranial sarco- mas: histopathological features of 19 cases. Histopathology. 1991;18(5):395–402. [3] Lee TT, Page LK. Primary cerebral leiomyosarcoma. Clinical Neurology and Neurosurgery. 1997;99(3):210–212. [4] Feigin I, Allen L, Lipkon L, Gross SW. The endothelial hyper- plasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer. 1957;11(2):264–277. [5] Brown HG, Burger PC, Olivi A, Sills AK, Barditch-Crovo PA, Lee RR. Intracranial leiomyosarcoma in a patient with AIDS. Neuroradiology. 1999;41(1):35–39. [6] Bejjani GK, Stopak B, Schwartz A, Santi R. Primary dural leiomyosarcoma in a patient infected with human immunode- ficiency virus: case report. Neurosurgery. 1999;44(1):199–202. [7] Niwa J, Hashi K, Minase T. Radiation induced intracra- nial leiomyosarcoma: its histopathological features. Acta Neu- rochirurgica. 1996;138(12):1470–1471. [8] Pasquier B, Couderc P, Pasquier D, et al. Les tumeurs ‘muscu- laires’ ou a composante myosarcomateuse primitives du sys- teme nerveux central. Semaine des Hopitaux de Paris. 1977; 53(36):1927–1940. MEDIATORS of INFLAMMATION The Scientific Gastroenterology Journal of World Journal Research and Practice Diabetes Research Disease Markers Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 International Journal of Journal of Immunology Research Endocrinology Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Submit your manuscripts at http://www.hindawi.com BioMed PPAR Research Research International Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Journal of Obesity Evidence-Based Journal of Journal of Stem Cells Complementary and Ophthalmology International Alternative Medicine Oncology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Parkinson’s Disease Computational and Behavioural Mathematical Methods AIDS Oxidative Medicine and in Medicine Research and Treatment Cellular Longevity Neurology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sarcoma Hindawi Publishing Corporation

Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature

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Hindawi Publishing Corporation
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Copyright © 2006 Sakeer Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract

Hindawi Publishing Corporation Sarcoma Volume 2006, Article ID 52140, Pages 1–3 DOI 10.1155/SRCM/2006/52140 Case Report Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature 1 2 3 4 1 Sakeer Hussain, Anil Nanda, Marjorie Fowler, Federico L. Ampil, and Gary V. Burton Department of Medicine, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Neurosurgery, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Pathology, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Department of Radiology, Feist Weiller Cancer Center, Louisiana State University Health Science Center - Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA Received 29 June 2006; Revised 13 October 2006; Accepted 13 October 2006 A 26-year old man presented with a 3-month history of a progressively enlarging palpable parieto-occipital mass. A CT scan indi- cated the lesion arose from the dura with bony destruction. A stealth assisted craniotomy was performed with the provisional diag- nosis of osteoblastic meningioma. Further histopathologic analysis of the intracranial mass was consistent with leiomyosarcoma. Staging evaluation, including CT and PET scans, demonstrated no other sites of disease. Despite complete surgical resection and radiotherapy to the resection site, the disease recurred locally and systematically 5 months later. Primary intracranial mesenchy- mal tumors are rare and few cases have been previously reported. Outcomes have been universally poor and current therapeutic approaches appear to have only limited benefit. Copyright © 2006 Sakeer Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION ment. There was no history of smoking, IV drug abuse, or sexual promiscuity. Physical examination was remarkable for Intracranial neoplasms of mesenchymal origin are uncom- a palpable 5 cm, fixed, nontender mass over the right parieto- mon. The majority of these tumors represent metastatic dis- occipital region. Complete blood counts and metabolic panel ease from other primary sites. Primary intracranial soft tis- were normal. Viral serology was negative for both human im- sue sarcomas can, however, arise from mesenchymal cells mune deficiency virus (HIV) and Epstein-Barr virus (EBV). of the dura matter or the cerebral blood vessels. These tu- A CT scan of the brain demonstrated a large highly vascu- mors often mimic meningioma on preoperative MRI and, al- lar soft tissue mass involving the meninges with invasion of though rare, should be included in the differential diagnosis the parietal bone and displacement of the brain parenchyma of dural-based lesions. Immunohistochemical stains can help (Figure 1). A clinical diagnosis of osteoblastic meningioma distinguishing these tumors from meningiomas. Postopera- was made. The patient underwent an uncomplicated stealth tive radiation and chemotherapy should be considered, how- assisted craniotomy with cranioplasty and gross microsur- ever, the prognosis has been universally poor. We describe the gical resection of the tumor. The tumor involved the dura course of a patient with a primary intracranial leiomyosar- mater and had eroded through the bony skull. The surgical coma and review the literature. margins were negative. The histologic examination demon- strated a malignant spindle cell neoplasm with immunos- tains positive for smooth muscle actin and negative for ep- CASE HISTORY ithelial membrane antigen (Figure 2). Pathologic interpreta- A 26-year old previously healthy male presented with a 3 tion was a malignant spindle cell neoplasm consistent with month history of progressively enlarging parieto-occipital high grade leiomyosarcoma with myxoid and epitheloid ar- mass. There were no constitutional or neurological symp- eas. Staging CT scan of the chest, abdomen and pelvis and toms and no symptoms suggestive of other sites of involve- PET scan were negative for other sites of involvement. The 2 Sarcoma (a) [PH] Figure 1: CT scan of the head shows a large vascular soft tissue mass involving the meninges and invasion of right parietal bone. patient received radiation therapy consisting of 61.8Gy in 34 fractions using involved field (tumor bed) megavoltage irra- diation. Adjuvant chemotherapy was declined by the patient. Five months following the surgery the patient developed pain in the right hip. An MRI of the right hip showed hetero- (b) geneous marrow replacement in the right ischium extend- ing to the acetabular marrow, with extraosseous soft tissue Figure 2: (a) Malignant spindle cells, pleomorphism, and high nu- component and small ipsilateral joint effusion. A CT scan cleocytoplasmic ratio. (b) Immunostain positive for smooth muscle showed multiple lung lesions and a 2.5 cm liver lesion. An actin. MRI of the brain revealed a suspicious small residual area at the parieto-occipital extradural space. Fine needle aspiration of the lung mass was performed and cytology was consistent with leiomyosarcoma. The patient initially declined systemic The association of these neoplasms with Epstein-Barr virus chemotherapy, but subsequently received liposomal doxoru- infection and AIDS is well documented in the literature bicin without response. He died 7 months after the initial [5, 6]. Our patient, however, had negative serology for both diagnosis. HIV and EBV infections. Radiation exposure has also been associated with an increased incidence of various soft tis- sue sarcomas. Intracranial leiomyosarcoma was reported 23 DISCUSSION years after radiation treatment for a pituitary adenoma [7]. Soft tissue sarcomas are rare tumors and account for only one Our review of primary intracranial myomatous tumors percent of all cancers [1]. Most intracranial soft tissue sarco- found that only one out of 29 reported cases demonstrated mas represent metastatic disease. Primary intracranial sarco- smooth muscle differentiation. The other cases were pure mas are extremely rare [2]. Intracranial sarcomas appear to mesenchymal or mixed neural and mesenchymal tumors originate from leptomeningeal lining and usually have du- showing skeletal muscle differentiation. Tumors with rhab- ral attachment [3]. Pleuripotent mesenchymal stem cells in domyomatous elements were more common than tumors the dura are probably the cells of origin. Intracerebral sar- containing leiomyosarcomatous characteristics [8]. comas may also arise from cerebral blood vessel epithelium In another study of 3829 patients with soft tissue sar- [4]. These tumors may also originate in the blood vessels out- coma, 21 patients presented with and 19 patients subse- side the dural surface and extend to the skull and meninges. quently developed brain metastases. In this study the most There was no definite evidence to confirm the origin of tu- frequent tumor type with metastatic brain involvement was mor in this case but involvement of the dura with invasion of leiomyosarcoma [9]. Leiomyosarcomas, however, tend to ex- the skull suggests a dural origin. hibit hematogenous spread to lung prior to the appearance An increased incidence of leiomyoma and leiomyosar- of brain metastases and, the metastasis usually involves brain coma has been observed in immunocompromised patients. parenchyma [9, 10]. Sakeer Hussain et al 3 The diagnosis of leiomyosarcoma is confirmed by ul- [9] Espat NJ, Bilsky M, Lewis JJ, Leung D, Brennan MF. Soft tis- sue sarcoma brain metastases: prevalence in a cohort of 3829 trastructural features of smooth muscle cells and immuno- patients. Cancer. 2002;94(10):2706–2711. histochemistry. The tumor cells are elongated with taper- [10] Haykal HA, Wang AM, Zamani A. Leiomyosarcoma metastatic ing cytoplasmic processes with elongated, convoluted nu- to the brain: CT features and review. American Journal of Neu- clei, pinocytic vesicles, and basement membrane material roradiology. 1987;8(5):911–912. around the cytoplasmic membrane. The differential diag- [11] Louis DN, Richardson EP Jr, Dickersin GR, Petrucci DA, noses, which include malignant astrocytoma, malignant fi- Rosenberg AE, Ojemann RG. Primary intracranial leiomyo- brous histocytoma, and meningioma, were excluded by im- sarcoma. Case report. Journal of Neurosurgery. 1989;71(2): munohistochemical testing. Our patient’s tumor was nega- 279–282. tive for S-100 protein and epithelial membrane antigen and positive for smooth muscle actin and cytokeratin staining. Although the pathologic and radiographic examination indicated a primary intracranial leiomyosarcoma in our pa- tient, another primary site could not be excluded with com- plete certainty. Within the limits of CT scan and other imag- ing modalities, the evaluation and the clinical course of our patient were consistent with a primary intracranial location. The prognosis for primary intracranial leiomyosarcoma is poor with the longest reported survival being 32 months [9, 11]. Patientsurvivalisprobablylimited by the difficulty in obtaining adequate surgical margins and an adequate ra- diation therapy dose to the intracranial location. Intracranial and meningeal tumor spread may also limit the benefits of systemic adjuvant chemotherapy. Despite these limitations, treatment should probably include aggressive application of multimodality therapy. A primary intracranial tumor of mesodermal origin is rare and the majority of these tumors are rhabdomyosar- coma. Leiomyosarcomas may mimic meningiomas on pre- operative MRI and, although extremely rare, must be in- cluded in the differential diagnosis of dural-based lesions REFERENCES [1] Weitz J, Antonescu CR, Brennan MF. Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time. Journal of Clinical Oncology. 2003;21(14):2719– [2] Paulus W, Slowik F, Jellinger K. Primary intracranial sarco- mas: histopathological features of 19 cases. Histopathology. 1991;18(5):395–402. [3] Lee TT, Page LK. Primary cerebral leiomyosarcoma. Clinical Neurology and Neurosurgery. 1997;99(3):210–212. [4] Feigin I, Allen L, Lipkon L, Gross SW. The endothelial hyper- plasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer. 1957;11(2):264–277. [5] Brown HG, Burger PC, Olivi A, Sills AK, Barditch-Crovo PA, Lee RR. Intracranial leiomyosarcoma in a patient with AIDS. Neuroradiology. 1999;41(1):35–39. [6] Bejjani GK, Stopak B, Schwartz A, Santi R. Primary dural leiomyosarcoma in a patient infected with human immunode- ficiency virus: case report. Neurosurgery. 1999;44(1):199–202. [7] Niwa J, Hashi K, Minase T. Radiation induced intracra- nial leiomyosarcoma: its histopathological features. Acta Neu- rochirurgica. 1996;138(12):1470–1471. [8] Pasquier B, Couderc P, Pasquier D, et al. Les tumeurs ‘muscu- laires’ ou a composante myosarcomateuse primitives du sys- teme nerveux central. Semaine des Hopitaux de Paris. 1977; 53(36):1927–1940. MEDIATORS of INFLAMMATION The Scientific Gastroenterology Journal of World Journal Research and Practice Diabetes Research Disease Markers Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 International Journal of Journal of Immunology Research Endocrinology Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Submit your manuscripts at http://www.hindawi.com BioMed PPAR Research Research International Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Journal of Obesity Evidence-Based Journal of Journal of Stem Cells Complementary and Ophthalmology International Alternative Medicine Oncology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Parkinson’s Disease Computational and Behavioural Mathematical Methods AIDS Oxidative Medicine and in Medicine Research and Treatment Cellular Longevity Neurology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014

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Sarcoma – Hindawi Publishing Corporation

Published: Dec 20, 2006

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