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Engineering Solutions for Cranio-Maxillo-Facial Rehabilitation and Oro-Dental Healthcare

Engineering Solutions for Cranio-Maxillo-Facial Rehabilitation and Oro-Dental Healthcare Hindawi Journal of Healthcare Engineering Volume 2019, Article ID 5387305, 3 pages https://doi.org/10.1155/2019/5387305 Editorial Engineering Solutions for Cranio-Maxillo-Facial Rehabilitation and Oro-Dental Healthcare 1,2,3,4 5 6 7 Ziyad S. Haidar , Lucy Di-Silvio, Ziad E. F. Noujeim , John E. Davies, 8 9 Fre´de´ric Cuisinier, and Avijit Banerjee BioMAT’X, Universidad de los Andes, Santiago, Chile Programa de Doctorado en BioMedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile Centro de Investigacio´n e Innovacio´n Biome´dica, Universidad de los Andes, Santiago, Chile Facultad de Odontolog´ıa, Universidad de los Andes, Santiago, Chile Department of Biomaterials and Biomimetics, King’s College London, London, UK Department of Oral Medicine and Maxillofacial Radiology, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada Laboratoire Bioing´enierie et Nanosciences, Universit´e de Montpellier, Montpellier, France Centre for Oral and Craniofacial Sciences, King’s College London, London, UK Correspondence should be addressed to Ziyad S. Haidar; zhaidar@uandes.cl Received 12 May 2019; Accepted 12 May 2019; Published 18 June 2019 Copyright©2019ZiyadS.Haidaretal.#isisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oro-dental health is an essential component of good overall potential for augmenting and improving the functional and health and well-being, and consequently, good oral and esthetic craniomaxillofacial and oro-dental health profile of dental health is indeed a fundamental human right, part of patients. A good example, perhaps, is nanoDentistry, clearly multidisciplinary and interdisciplinary, building on existing the main role, and goal of the dental profession with all its interdisciplinary and multidisciplinary subspecialties to help knowledge and accruing expertise in different scientific and the population achieve a stable and healthy craniomax- technological fields, seeking persistent refinement of tradi- illofacial complex. Hence, identifying challenges and op- tional approaches, via the development and/or incorporation portunities needs to be in the forefront of our priorities, of advanced biomaterials, new functional tools, and pharma- especially considering the mounting ageing population and cological formulations to improve overall oro-dental practice swelling demand for oro-dental healthcare, products, ser- and care. While slowly evolving, nanoDentistry is expected to vices, and alternative solutions. It is noteworthy herein that provide dentists and surgeons with more precision-made and this agrees with and supports the global 2020 vision of the tailored materials, drugs, and equipment, by which safety, ´ ´ esthetics, function/efficacy, and patient compliance are en- FDI (Federation Dentaire Internationale) World Dental Federation, the world’s leading dental professional organi- hanced. Due to the complex nature of such “outside-the-box” zation, on oral and dental health, where it is proposed and (or even “no-box”) healthcare-related engineering problem– urged to expand the role of existing oral and dental solution technologies, they have attracted experts from physics, healthcare professionals and foster fundamental research chemistry, biology, materials science, pharmaceutics, robotics, and translational technologies, to better mitigate the impacts and bioengineering, as well as the industry. #e ultimatum is of socioeconomic dynamics, a cornerstone for the projection improved overall healthcare and well-being with a positive of this special issue. impact on socioeconomics and quality of life. In brief, innovative engineering solutions that incorporate Hence, this special issue is intended to bring together advanced biomaterials, nanobiotechnology,three-dimensional a collection of original and state-of-the-art works in oro- printing, computer assistance, and robotic systems offer huge dental and craniomaxillofacial healthcare and related 2 Journal of Healthcare Engineering #e paper entitled “Bone Loss around Dental Implants topics to exhibit the latest ideas, concepts, findings, achievements, and future projections and promote 5Years after Implantation of Biphasic Calcium Phosphate (HAp/βTCP) Granules” by V. Klimecs et al. deals with awareness of the rapidly evolving and enabling multi- disciplinary technology, thereby encouraging a fruitful implant dentistry as well and addresses the issue of alveolar dialogue to bridge the gap between engineering and bone loss around dental implants, clinically, and its impact dentistry (including subspecialties, extending to the head on dental implant therapy failure. For this purpose, the and neck) for research and innovation collaboration authors developed and used combinatorial bioceramic across the fields to address the critical and urgent granules as a filler biomaterial in eighteen patients suffering biodental/biomedical concerns. In particular, this special peri-implantitis, an infectious disease that causes an in- flammatory process in soft tissues and bone loss around an issue assembles six original contributions presenting recent advances in biomechanical properties of peri- osseointegrated implant. Clinical evaluation and radiological (3D cone-beam computed tomography) measurements were odontal tissues and metal-based biomaterials, as well as stimulating mathematical modeling methods as funda- done, after a 5-year period, to compare the situation before and after treatment of peri-implantitis with the use of dif- mental and expedited analytical tools, for clinical use. Different areas of engineering solutions, once more, ferent bioceramic materials (pure calcium hydroxyapatite vs. clearly support the previously mentioned growing need combined hydroxyapatite and β-tricalcium phosphate). #is and our hope to bridge the disciplinary communication is a registered clinical trial, providing densitometry and and collaboration gap, through this contribution. mineralization data of bone structures. In no particular order, the paper by C. Sinescu et al. On the contrary, S. Wang et al., in the article entitled entitled “Mechanical Properties of the Periodontal System “Automatic Analysis of Lateral Cephalograms Based on Multiresolution Decision Tree Regression Voting,” de- and of Dental Constructs Deduced from the Free Response of the Tooth” explores the biomechanical behavior of the veloped a fully automatic system to aid in the analysis of cephalograms, a traditional, conventional, and standard periodontal ligament (PDL), the fibrous connective and neurovascular tissue that connects the dentition (cementum two-dimensional radiological X-ray of the craniofacial area (lateral side of the head) often used in orthodontic and part of the root of an individual tooth) to the surrounding alveolar bone, for proper and healthy support of mastication orthognathic areas to assess and predict craniofacial and nutritional intake, among other key oro-dental func- growth. It is also commonly used for clinical orthodontic tions detrimental for an overall general health, well-being, diagnosis and oromaxillofacial treatment planning pur- and quality of life. By analyzing clinical and mathematical poses. Lateral cephalograms often require a specialist to studies, the authors introduce a new method for the eval- analyze and identify specific landmarks. Herein, a new uation of biomechanical and elastometric parameters of the framework for landmark detection in lateral cephalograms with low-to-high resolutions is designed. #e algorithmic tooth-PDL system, using an ultrasound probe, in different clinical scenarios and conditions. #is study presents a linear method employs multiscale decision tree regression voting in landmark detection, in each image resolution (low vs. model in good accordance with physical phenomena that would help the dentist and/or prosthodontist (oro-dental high). Patch feature extraction is based on scale-invariant rehabilitation specialist) provide better prosthesis (such as feature transform algorithms. Basically, information can be crowns and bridges) and postoperative care for the patient, extracted to predict the positions of the anatomical to help prevent periodontal and/or masticatory diseases or at structure involving the specific landmarks (45, double the least arrest the adverse consequences on the well-being of the landmarks often detected by benchmark databases), with a patient. decent average of 72% successful detection rate within a L. Bai et al. in the paper entitled “Mechanical Charac- precision range of 2.0mm. #is is another fine example of terization of 3D-Printed Individualized Ti-Mesh (Mem- “outside-the-box” multidisciplinary and multinational collaborative novelty for engineering solutions in health. brane) for Alveolar Bone Defects” describe the importance of sufficient bone volume in implant dentistry, in both the Likewise, the paper by D. Xu et al. entitled “Interactive Compliance Control of a Wrist Rehabilitation Device horizontal and vertical dimensions, and how it plays a vital role in achieving long-term esthetic and functional results. (WReD) with Enhanced Training Safety” is an inordinate Herein, using computer-assisted design and additive illustration of different disciplines and areas of research manufacturing technology, a custom-made (personalized/ coming together. It deals with human-robot interactive tasks case-by-case) titanium (Ti) mesh is developed. It is deemed (and interaction control), robot-assisted rehabilitation so- superior to conventional and commercially available lutions, and physical therapy, to improve the safety and meshes, taking into consideration, via three-dimensional efficacy of training and compliance adaptation of in- teraction, as are vital for enabling robotic or robot-specific finite element analysis, the effect of pore size and thick- ness on the mechanical properties of the Ti mesh, as well as movements to better suit the varying and/or personalized requirements of individual patients. Herein, this work variances in size and anatomical location of bone defects. Clinically, this original effort might eventually translate to proposes an interactive compliance control scheme on a wrist rehabilitation device, with satisfactory trajectory shortening the duration of the surgical procedure(s) as well as minimizing if not alleviating or eliminating the risk of tracking responses. Interestingly, this interactive compliance postoperative infections, a fine example of multidisciplinary control method can adaptively adjust the range of training healthcare engineering research. motions and encourage active engagement from human Journal of Healthcare Engineering 3 users simultaneously, opening doors wide for more clinical BioMAT’X R&D&I Team, Faculty of Dentistry at the applications. It is perhaps worth mentioning, for the in- Universidad de los Andes for their technical support (FAI- terested reader, that the interactive compliance control of the UANDESINV-IN-2015-101,CONCIYT-FONDEF ID16|10366, wrist rehabilitation device was achieved based on an ad- and CORFO 18COTE-89695). mittance law (where the device deviates from the reference trajectory in the presence of patient-robot interaction nev- Ziyad S. Haidar ertheless is also still following the reference trajectory—read Lucy Di Silvio article for more inspiring details!) due to the availability of Ziad E. F. Noujeim direct measurement of the interaction torque. John E. Davies Last but not least, G. P. Panotopoulos et al. revisit the Fr´ed´eric Cuisinier controversial issue of cell migration and cell-to-cell com- Avijit Banerjee munications in the article entitled “Non-Motile Single-Cell Migration as a Random Walk in Non-Uniformity: #e “Extreme Dumping Limit” for Cell-to-Cell Communica- tions.” Single-cell movement as a random walk in an ex- ternal potential, observed within the extreme dumping limit (defined herein as the extreme nonuniform behavior ob- served for cell responses and cell-to-cell communications), is mathematically modeled in this work. #e authors attempt to solve the Fokker–Planck equation in order to compute higher “moments” of the displacement of the cell and then build experimentally measurable quantities. Seemingly, the dynamics depend, every time, on the external force applied, leading to predictions distinct from standard results of a free Brownian particle. #is demonstrates that cell migration viewed as a stochastic process is still compatible with bi- ological and experimental observations without the need to rely on more complicated or sophisticated models pre- viously proposed in the literature. #e derived model and equation could be potentially beneficial to explain cellular migration during relevant biological processes, including wound healing, inflammation, and embryonic development, via a minimalistic approach. Finally, while we believe and aspire that this special issue will be useful and inspiring for scientists, researchers, en- gineers, and clinical practitioners involved in healthcare engineering solutions, it is recommended to pay special attention to the potentially impactful role of applied bio- dental tissue engineering, drug/gene delivery (controlled and metered systems) and cell therapy, image-guided and -assisted surgery, and nanoDentistry and green dentistry, towards developing better solutions for problems and conditions of the oro-dental and cranio-maxillo-facial complex. Conflicts of Interest #e guest editorial team declare that they have no conflicts of interest regarding the publication of the special issue. Acknowledgments #e guest editorial team would like to express gratitude to all the contributing authors and anonymous reviewers for their interest in selecting this special issue as a venue for dis- seminating their scholarly work and for their driven, careful, and insightful reading, appraisal, commentaries, and sug- gestions of the received manuscripts, respectfully. Finally, the lead guest editor is pleased to particularly thank the International Journal of Advances in Rotating Machinery Multimedia Journal of The Scientific Journal of Engineering World Journal Sensors Hindawi Hindawi Publishing Corporation Hindawi Hindawi Hindawi Hindawi www.hindawi.com Volume 2018 http://www www.hindawi.com .hindawi.com V Volume 2018 olume 2013 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 Journal of Control Science and Engineering Advances in Civil Engineering Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 Submit your manuscripts at www.hindawi.com Journal of Journal of Electrical and Computer Robotics Engineering Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 VLSI Design Advances in OptoElectronics International Journal of Modelling & Aerospace International Journal of Simulation Navigation and in Engineering Engineering Observation Hindawi Hindawi Hindawi Hindawi Volume 2018 Volume 2018 Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com www.hindawi.com www.hindawi.com Volume 2018 International Journal of Active and Passive International Journal of Antennas and Advances in Chemical Engineering Propagation Electronic Components Shock and Vibration Acoustics and Vibration Hindawi Hindawi Hindawi Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Healthcare Engineering Hindawi Publishing Corporation

Engineering Solutions for Cranio-Maxillo-Facial Rehabilitation and Oro-Dental Healthcare

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Publisher
Hindawi Publishing Corporation
Copyright
Copyright © 2019 Ziyad S. Haidar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN
2040-2295
eISSN
2040-2309
DOI
10.1155/2019/5387305
Publisher site
See Article on Publisher Site

Abstract

Hindawi Journal of Healthcare Engineering Volume 2019, Article ID 5387305, 3 pages https://doi.org/10.1155/2019/5387305 Editorial Engineering Solutions for Cranio-Maxillo-Facial Rehabilitation and Oro-Dental Healthcare 1,2,3,4 5 6 7 Ziyad S. Haidar , Lucy Di-Silvio, Ziad E. F. Noujeim , John E. Davies, 8 9 Fre´de´ric Cuisinier, and Avijit Banerjee BioMAT’X, Universidad de los Andes, Santiago, Chile Programa de Doctorado en BioMedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile Centro de Investigacio´n e Innovacio´n Biome´dica, Universidad de los Andes, Santiago, Chile Facultad de Odontolog´ıa, Universidad de los Andes, Santiago, Chile Department of Biomaterials and Biomimetics, King’s College London, London, UK Department of Oral Medicine and Maxillofacial Radiology, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada Laboratoire Bioing´enierie et Nanosciences, Universit´e de Montpellier, Montpellier, France Centre for Oral and Craniofacial Sciences, King’s College London, London, UK Correspondence should be addressed to Ziyad S. Haidar; zhaidar@uandes.cl Received 12 May 2019; Accepted 12 May 2019; Published 18 June 2019 Copyright©2019ZiyadS.Haidaretal.#isisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oro-dental health is an essential component of good overall potential for augmenting and improving the functional and health and well-being, and consequently, good oral and esthetic craniomaxillofacial and oro-dental health profile of dental health is indeed a fundamental human right, part of patients. A good example, perhaps, is nanoDentistry, clearly multidisciplinary and interdisciplinary, building on existing the main role, and goal of the dental profession with all its interdisciplinary and multidisciplinary subspecialties to help knowledge and accruing expertise in different scientific and the population achieve a stable and healthy craniomax- technological fields, seeking persistent refinement of tradi- illofacial complex. Hence, identifying challenges and op- tional approaches, via the development and/or incorporation portunities needs to be in the forefront of our priorities, of advanced biomaterials, new functional tools, and pharma- especially considering the mounting ageing population and cological formulations to improve overall oro-dental practice swelling demand for oro-dental healthcare, products, ser- and care. While slowly evolving, nanoDentistry is expected to vices, and alternative solutions. It is noteworthy herein that provide dentists and surgeons with more precision-made and this agrees with and supports the global 2020 vision of the tailored materials, drugs, and equipment, by which safety, ´ ´ esthetics, function/efficacy, and patient compliance are en- FDI (Federation Dentaire Internationale) World Dental Federation, the world’s leading dental professional organi- hanced. Due to the complex nature of such “outside-the-box” zation, on oral and dental health, where it is proposed and (or even “no-box”) healthcare-related engineering problem– urged to expand the role of existing oral and dental solution technologies, they have attracted experts from physics, healthcare professionals and foster fundamental research chemistry, biology, materials science, pharmaceutics, robotics, and translational technologies, to better mitigate the impacts and bioengineering, as well as the industry. #e ultimatum is of socioeconomic dynamics, a cornerstone for the projection improved overall healthcare and well-being with a positive of this special issue. impact on socioeconomics and quality of life. In brief, innovative engineering solutions that incorporate Hence, this special issue is intended to bring together advanced biomaterials, nanobiotechnology,three-dimensional a collection of original and state-of-the-art works in oro- printing, computer assistance, and robotic systems offer huge dental and craniomaxillofacial healthcare and related 2 Journal of Healthcare Engineering #e paper entitled “Bone Loss around Dental Implants topics to exhibit the latest ideas, concepts, findings, achievements, and future projections and promote 5Years after Implantation of Biphasic Calcium Phosphate (HAp/βTCP) Granules” by V. Klimecs et al. deals with awareness of the rapidly evolving and enabling multi- disciplinary technology, thereby encouraging a fruitful implant dentistry as well and addresses the issue of alveolar dialogue to bridge the gap between engineering and bone loss around dental implants, clinically, and its impact dentistry (including subspecialties, extending to the head on dental implant therapy failure. For this purpose, the and neck) for research and innovation collaboration authors developed and used combinatorial bioceramic across the fields to address the critical and urgent granules as a filler biomaterial in eighteen patients suffering biodental/biomedical concerns. In particular, this special peri-implantitis, an infectious disease that causes an in- flammatory process in soft tissues and bone loss around an issue assembles six original contributions presenting recent advances in biomechanical properties of peri- osseointegrated implant. Clinical evaluation and radiological (3D cone-beam computed tomography) measurements were odontal tissues and metal-based biomaterials, as well as stimulating mathematical modeling methods as funda- done, after a 5-year period, to compare the situation before and after treatment of peri-implantitis with the use of dif- mental and expedited analytical tools, for clinical use. Different areas of engineering solutions, once more, ferent bioceramic materials (pure calcium hydroxyapatite vs. clearly support the previously mentioned growing need combined hydroxyapatite and β-tricalcium phosphate). #is and our hope to bridge the disciplinary communication is a registered clinical trial, providing densitometry and and collaboration gap, through this contribution. mineralization data of bone structures. In no particular order, the paper by C. Sinescu et al. On the contrary, S. Wang et al., in the article entitled entitled “Mechanical Properties of the Periodontal System “Automatic Analysis of Lateral Cephalograms Based on Multiresolution Decision Tree Regression Voting,” de- and of Dental Constructs Deduced from the Free Response of the Tooth” explores the biomechanical behavior of the veloped a fully automatic system to aid in the analysis of cephalograms, a traditional, conventional, and standard periodontal ligament (PDL), the fibrous connective and neurovascular tissue that connects the dentition (cementum two-dimensional radiological X-ray of the craniofacial area (lateral side of the head) often used in orthodontic and part of the root of an individual tooth) to the surrounding alveolar bone, for proper and healthy support of mastication orthognathic areas to assess and predict craniofacial and nutritional intake, among other key oro-dental func- growth. It is also commonly used for clinical orthodontic tions detrimental for an overall general health, well-being, diagnosis and oromaxillofacial treatment planning pur- and quality of life. By analyzing clinical and mathematical poses. Lateral cephalograms often require a specialist to studies, the authors introduce a new method for the eval- analyze and identify specific landmarks. Herein, a new uation of biomechanical and elastometric parameters of the framework for landmark detection in lateral cephalograms with low-to-high resolutions is designed. #e algorithmic tooth-PDL system, using an ultrasound probe, in different clinical scenarios and conditions. #is study presents a linear method employs multiscale decision tree regression voting in landmark detection, in each image resolution (low vs. model in good accordance with physical phenomena that would help the dentist and/or prosthodontist (oro-dental high). Patch feature extraction is based on scale-invariant rehabilitation specialist) provide better prosthesis (such as feature transform algorithms. Basically, information can be crowns and bridges) and postoperative care for the patient, extracted to predict the positions of the anatomical to help prevent periodontal and/or masticatory diseases or at structure involving the specific landmarks (45, double the least arrest the adverse consequences on the well-being of the landmarks often detected by benchmark databases), with a patient. decent average of 72% successful detection rate within a L. Bai et al. in the paper entitled “Mechanical Charac- precision range of 2.0mm. #is is another fine example of terization of 3D-Printed Individualized Ti-Mesh (Mem- “outside-the-box” multidisciplinary and multinational collaborative novelty for engineering solutions in health. brane) for Alveolar Bone Defects” describe the importance of sufficient bone volume in implant dentistry, in both the Likewise, the paper by D. Xu et al. entitled “Interactive Compliance Control of a Wrist Rehabilitation Device horizontal and vertical dimensions, and how it plays a vital role in achieving long-term esthetic and functional results. (WReD) with Enhanced Training Safety” is an inordinate Herein, using computer-assisted design and additive illustration of different disciplines and areas of research manufacturing technology, a custom-made (personalized/ coming together. It deals with human-robot interactive tasks case-by-case) titanium (Ti) mesh is developed. It is deemed (and interaction control), robot-assisted rehabilitation so- superior to conventional and commercially available lutions, and physical therapy, to improve the safety and meshes, taking into consideration, via three-dimensional efficacy of training and compliance adaptation of in- teraction, as are vital for enabling robotic or robot-specific finite element analysis, the effect of pore size and thick- ness on the mechanical properties of the Ti mesh, as well as movements to better suit the varying and/or personalized requirements of individual patients. Herein, this work variances in size and anatomical location of bone defects. Clinically, this original effort might eventually translate to proposes an interactive compliance control scheme on a wrist rehabilitation device, with satisfactory trajectory shortening the duration of the surgical procedure(s) as well as minimizing if not alleviating or eliminating the risk of tracking responses. Interestingly, this interactive compliance postoperative infections, a fine example of multidisciplinary control method can adaptively adjust the range of training healthcare engineering research. motions and encourage active engagement from human Journal of Healthcare Engineering 3 users simultaneously, opening doors wide for more clinical BioMAT’X R&D&I Team, Faculty of Dentistry at the applications. It is perhaps worth mentioning, for the in- Universidad de los Andes for their technical support (FAI- terested reader, that the interactive compliance control of the UANDESINV-IN-2015-101,CONCIYT-FONDEF ID16|10366, wrist rehabilitation device was achieved based on an ad- and CORFO 18COTE-89695). mittance law (where the device deviates from the reference trajectory in the presence of patient-robot interaction nev- Ziyad S. Haidar ertheless is also still following the reference trajectory—read Lucy Di Silvio article for more inspiring details!) due to the availability of Ziad E. F. Noujeim direct measurement of the interaction torque. John E. Davies Last but not least, G. P. Panotopoulos et al. revisit the Fr´ed´eric Cuisinier controversial issue of cell migration and cell-to-cell com- Avijit Banerjee munications in the article entitled “Non-Motile Single-Cell Migration as a Random Walk in Non-Uniformity: #e “Extreme Dumping Limit” for Cell-to-Cell Communica- tions.” Single-cell movement as a random walk in an ex- ternal potential, observed within the extreme dumping limit (defined herein as the extreme nonuniform behavior ob- served for cell responses and cell-to-cell communications), is mathematically modeled in this work. #e authors attempt to solve the Fokker–Planck equation in order to compute higher “moments” of the displacement of the cell and then build experimentally measurable quantities. Seemingly, the dynamics depend, every time, on the external force applied, leading to predictions distinct from standard results of a free Brownian particle. #is demonstrates that cell migration viewed as a stochastic process is still compatible with bi- ological and experimental observations without the need to rely on more complicated or sophisticated models pre- viously proposed in the literature. #e derived model and equation could be potentially beneficial to explain cellular migration during relevant biological processes, including wound healing, inflammation, and embryonic development, via a minimalistic approach. Finally, while we believe and aspire that this special issue will be useful and inspiring for scientists, researchers, en- gineers, and clinical practitioners involved in healthcare engineering solutions, it is recommended to pay special attention to the potentially impactful role of applied bio- dental tissue engineering, drug/gene delivery (controlled and metered systems) and cell therapy, image-guided and -assisted surgery, and nanoDentistry and green dentistry, towards developing better solutions for problems and conditions of the oro-dental and cranio-maxillo-facial complex. Conflicts of Interest #e guest editorial team declare that they have no conflicts of interest regarding the publication of the special issue. Acknowledgments #e guest editorial team would like to express gratitude to all the contributing authors and anonymous reviewers for their interest in selecting this special issue as a venue for dis- seminating their scholarly work and for their driven, careful, and insightful reading, appraisal, commentaries, and sug- gestions of the received manuscripts, respectfully. Finally, the lead guest editor is pleased to particularly thank the International Journal of Advances in Rotating Machinery Multimedia Journal of The Scientific Journal of Engineering World Journal Sensors Hindawi Hindawi Publishing Corporation Hindawi Hindawi Hindawi Hindawi www.hindawi.com Volume 2018 http://www www.hindawi.com .hindawi.com V Volume 2018 olume 2013 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 Journal of Control Science and Engineering Advances in Civil Engineering Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 Submit your manuscripts at www.hindawi.com Journal of Journal of Electrical and Computer Robotics Engineering Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 VLSI Design Advances in OptoElectronics International Journal of Modelling & Aerospace International Journal of Simulation Navigation and in Engineering Engineering Observation Hindawi Hindawi Hindawi Hindawi Volume 2018 Volume 2018 Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com www.hindawi.com www.hindawi.com Volume 2018 International Journal of Active and Passive International Journal of Antennas and Advances in Chemical Engineering Propagation Electronic Components Shock and Vibration Acoustics and Vibration Hindawi Hindawi Hindawi Hindawi Hindawi www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018 www.hindawi.com Volume 2018

Journal

Journal of Healthcare EngineeringHindawi Publishing Corporation

Published: Jun 18, 2019

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