Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013

Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013 Hindawi Publishing Corporation International Journal of Alzheimer’s Disease Volume 2013, Article ID 838274, 2 pages http://dx.doi.org/10.1155/2013/838274 Editorial Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013 1,2 3 4 Rosanna Squitti, Tjaard Hoogenraad, George Brewer, 5 6 Ashley I. Bush, and Renato Polimanti Department of Neuroscience, AFaR-Ospedale “San Giovanni Calibita” Fatebenefratelli, Isola Tiberina, 00186 Rome, Italy Neurodegeneration Laboratory, IRCCS San Raa ff ele Pisana, 00166 Rome, Italy Department of Neurology, University Hospital Utrecht, 3584 CX Utrecht, eTh Netherlands Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA Florey Institute of Neuroscience & Mental Health, University of Melbourne, Melbourne, VIC 3053, Australia Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy Correspondence should be addressed to Rosanna Squitti; rosanna.squitti@afar.it Received 18 November 2013; Accepted 18 November 2013 Copyright © 2013 Rosanna Squitti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In recent years, the number of studies about the role of copper a 2% cholesterol diet to explore the role of copper in drink- metabolism in the pathophysiology of Alzheimer’s disease ing water in determining the AD progression, especially high- (AD) has been rapidly increasing. A wide range of experi- lighting theoutstanding contribution of thelateD.L.Sparks. mental approaches have been used to explore this important Another paper is provided by K. Singh and collaborators. issue: in vitro analyses, investigations on animal models, They present novel data about the positive eeff cts of a new bioinformatic surveys, and patients’ studies. Most of these copper chelator, L-2,6-pyridinedicarboxylic acid, 2,6-bis[2- studies have indicated that systemic disarrangements of [(4-carboxyphenyl) methylene] hydrazide], in the eye tissues copper metabolism can be one of the pathologic pathways of transgenic Drosophila expressing beta-amyloid (A𝛽 ). at the basis of AD, and moreover, preventive and therapeutic Oneofthe paperisareview articlebyG.J.Brewerand S. strategies based on copper may be developed in order to slow Kaur about the importance of ingestion of inorganic copper down or to block the disease progression. However, further (suchasthatofdrinkingwater)asapossible factor of AD studies are necessary to translate these ndin fi gs into clinical causation and of zinc therapy to reduce serum “free” copper practice. In 2011, the International Journal of Alzheimer’s levels and, consequently, to slow down cognition loss in AD Disease(IJAD)published theannualissue“Copper Status in patients. ey Th also furnished novel data about a 6-month Alzheimer’s Disease and Other Neurodegenerative Disorders”, small double blind trial of a new zinc formulation on AD in order to collect some relevant studies about copper and patients. AD. Aeft r two years, due to the growing literature about In another paper, A. Rembach and colleagues show their this topic, we andIJADhavedecided to presentthe 2013 outcomes on the brain-specific alteration in copper levels of annual issue. In this issue, studies from dieff rent international AD patients. Specifically, they observed that the decrease of authors are published about the recent advances in the efi ld copper in the human frontal cortex was conn fi ed in the sol- of copper metabolism in AD. We decided to include inves- uble fractions. tigations based on different approaches in order to display Two of the papers are two research articles provided by the multiplicity of experimental methodologies, currently N. Arnal and collaborators. In these papers, they display the present to investigate this important subject. interactions between copper and cholesterol in neurodegen- Oneofthe paperofthisannualissueisareview articleby erative processes of Wistar rats and the effects of copper and B. G. Schreurs about the use of the AD rabbit model based on cholesterol on mitochondrial function in a rat model. 2 International Journal of Alzheimer’s Disease Another paper is a review article by X. Y. Choo and collab- orators. In this review, the authors focused their attention on AD-related inflammation, highlighting recent advances on the role of copper as modulator of inflammatory processes in AD. Finally, last but not least, there is the paper by C. Salustri and collaborators. In this research article, the authors provide novel information about the role of copper in the neurophys- iology of AD. Specifically, they investigated whether copper dysfunction aeff cts neurotransmission in AD patients, high- lighting the association between copper and glutamatergic and Gabaergic transmission. In conclusion, we provided an issue with a wide range of experimental evidence about the relevant role of copper in AD pathogenesis. Although we are still far to completely understand this important topic, the data present can help the reader to better understand the recent advance in this research efi ld. Rosanna Squitti Tjaard Hoogenraad George Brewer Ashley I. Bush Renato Polimanti MEDIATORS of INFLAMMATION The Scientific Gastroenterology Journal of World Journal Research and Practice Diabetes Research Disease Markers Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 International Journal of Journal of Immunology Research Endocrinology Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Submit your manuscripts at http://www.hindawi.com BioMed PPAR Research Research International Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Journal of Obesity Evidence-Based Journal of Journal of Stem Cells Complementary and Ophthalmology International Alternative Medicine Oncology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Parkinson’s Disease Computational and Behavioural Mathematical Methods AIDS Oxidative Medicine and in Medicine Research and Treatment Cellular Longevity Neurology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Alzheimer's Disease Hindawi Publishing Corporation

Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013

Loading next page...
 
/lp/hindawi-publishing-corporation/copper-status-in-alzheimer-s-disease-and-other-neurodegenerative-d8KooGPdid

References (2)

Publisher
Hindawi Publishing Corporation
Copyright
Copyright © 2013 Rosanna Squitti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN
2090-8024
DOI
10.1155/2013/838274
Publisher site
See Article on Publisher Site

Abstract

Hindawi Publishing Corporation International Journal of Alzheimer’s Disease Volume 2013, Article ID 838274, 2 pages http://dx.doi.org/10.1155/2013/838274 Editorial Copper Status in Alzheimer’s Disease and Other Neurodegenerative Disorders 2013 1,2 3 4 Rosanna Squitti, Tjaard Hoogenraad, George Brewer, 5 6 Ashley I. Bush, and Renato Polimanti Department of Neuroscience, AFaR-Ospedale “San Giovanni Calibita” Fatebenefratelli, Isola Tiberina, 00186 Rome, Italy Neurodegeneration Laboratory, IRCCS San Raa ff ele Pisana, 00166 Rome, Italy Department of Neurology, University Hospital Utrecht, 3584 CX Utrecht, eTh Netherlands Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA Florey Institute of Neuroscience & Mental Health, University of Melbourne, Melbourne, VIC 3053, Australia Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy Correspondence should be addressed to Rosanna Squitti; rosanna.squitti@afar.it Received 18 November 2013; Accepted 18 November 2013 Copyright © 2013 Rosanna Squitti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In recent years, the number of studies about the role of copper a 2% cholesterol diet to explore the role of copper in drink- metabolism in the pathophysiology of Alzheimer’s disease ing water in determining the AD progression, especially high- (AD) has been rapidly increasing. A wide range of experi- lighting theoutstanding contribution of thelateD.L.Sparks. mental approaches have been used to explore this important Another paper is provided by K. Singh and collaborators. issue: in vitro analyses, investigations on animal models, They present novel data about the positive eeff cts of a new bioinformatic surveys, and patients’ studies. Most of these copper chelator, L-2,6-pyridinedicarboxylic acid, 2,6-bis[2- studies have indicated that systemic disarrangements of [(4-carboxyphenyl) methylene] hydrazide], in the eye tissues copper metabolism can be one of the pathologic pathways of transgenic Drosophila expressing beta-amyloid (A𝛽 ). at the basis of AD, and moreover, preventive and therapeutic Oneofthe paperisareview articlebyG.J.Brewerand S. strategies based on copper may be developed in order to slow Kaur about the importance of ingestion of inorganic copper down or to block the disease progression. However, further (suchasthatofdrinkingwater)asapossible factor of AD studies are necessary to translate these ndin fi gs into clinical causation and of zinc therapy to reduce serum “free” copper practice. In 2011, the International Journal of Alzheimer’s levels and, consequently, to slow down cognition loss in AD Disease(IJAD)published theannualissue“Copper Status in patients. ey Th also furnished novel data about a 6-month Alzheimer’s Disease and Other Neurodegenerative Disorders”, small double blind trial of a new zinc formulation on AD in order to collect some relevant studies about copper and patients. AD. Aeft r two years, due to the growing literature about In another paper, A. Rembach and colleagues show their this topic, we andIJADhavedecided to presentthe 2013 outcomes on the brain-specific alteration in copper levels of annual issue. In this issue, studies from dieff rent international AD patients. Specifically, they observed that the decrease of authors are published about the recent advances in the efi ld copper in the human frontal cortex was conn fi ed in the sol- of copper metabolism in AD. We decided to include inves- uble fractions. tigations based on different approaches in order to display Two of the papers are two research articles provided by the multiplicity of experimental methodologies, currently N. Arnal and collaborators. In these papers, they display the present to investigate this important subject. interactions between copper and cholesterol in neurodegen- Oneofthe paperofthisannualissueisareview articleby erative processes of Wistar rats and the effects of copper and B. G. Schreurs about the use of the AD rabbit model based on cholesterol on mitochondrial function in a rat model. 2 International Journal of Alzheimer’s Disease Another paper is a review article by X. Y. Choo and collab- orators. In this review, the authors focused their attention on AD-related inflammation, highlighting recent advances on the role of copper as modulator of inflammatory processes in AD. Finally, last but not least, there is the paper by C. Salustri and collaborators. In this research article, the authors provide novel information about the role of copper in the neurophys- iology of AD. Specifically, they investigated whether copper dysfunction aeff cts neurotransmission in AD patients, high- lighting the association between copper and glutamatergic and Gabaergic transmission. In conclusion, we provided an issue with a wide range of experimental evidence about the relevant role of copper in AD pathogenesis. Although we are still far to completely understand this important topic, the data present can help the reader to better understand the recent advance in this research efi ld. Rosanna Squitti Tjaard Hoogenraad George Brewer Ashley I. Bush Renato Polimanti MEDIATORS of INFLAMMATION The Scientific Gastroenterology Journal of World Journal Research and Practice Diabetes Research Disease Markers Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 International Journal of Journal of Immunology Research Endocrinology Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Submit your manuscripts at http://www.hindawi.com BioMed PPAR Research Research International Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Journal of Obesity Evidence-Based Journal of Journal of Stem Cells Complementary and Ophthalmology International Alternative Medicine Oncology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 Parkinson’s Disease Computational and Behavioural Mathematical Methods AIDS Oxidative Medicine and in Medicine Research and Treatment Cellular Longevity Neurology Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation Hindawi Publishing Corporation http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014

Journal

International Journal of Alzheimer's DiseaseHindawi Publishing Corporation

Published: Dec 19, 2013

There are no references for this article.