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The physiological and mononuclear cell activation response to cryotherapy following a mixed martial arts contest: a pilot study

The physiological and mononuclear cell activation response to cryotherapy following a mixed... Abstract Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin generation. Urine was collected from 10 elite male mixed martial artists before, immediately post and 1, 2, 24 and 48 h following a contest. Myoglobin was analysed by reverse-phase high performance liquid chromatography, and urinary neopterin and total neopterin (neopterin+7,8-dihydroneopterin) were measured by strong cation exchange high-performance liquid chromatography. Cold water immersion and passive recovery were compared using changes in these markers, while cryotherapy tested total neopterin production in γ-interferon and phorbol myristate acetate (PMA)-stimulated blood-derived mononuclear cells (monocytes/T cells). Myoglobin significantly increased (p<0.05) at 1 h post-contest, neopterin significantly increased at 1 and 24 h (p<0.05), total neopterin significantly increased (p<0.05) at 1 h post for the passive group only, and significant individual variation was observed for all markers (p<0.01). Cold water immersion attenuated total neopterin production (p<0.05), while cryotherapy significantly reduced total neopterin production in PMA-stimulated mononuclear cells (p<0.01). Cryotherapy attenuates the post-exercise inflammatory response following an MMA contest. The evidence also suggests that the mechanisms responsible for this may be related to direct immune cell suppression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

The physiological and mononuclear cell activation response to cryotherapy following a mixed martial arts contest: a pilot study

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Publisher
de Gruyter
Copyright
Copyright © 2015 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pterid-2015-0010
Publisher site
See Article on Publisher Site

Abstract

Abstract Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin generation. Urine was collected from 10 elite male mixed martial artists before, immediately post and 1, 2, 24 and 48 h following a contest. Myoglobin was analysed by reverse-phase high performance liquid chromatography, and urinary neopterin and total neopterin (neopterin+7,8-dihydroneopterin) were measured by strong cation exchange high-performance liquid chromatography. Cold water immersion and passive recovery were compared using changes in these markers, while cryotherapy tested total neopterin production in γ-interferon and phorbol myristate acetate (PMA)-stimulated blood-derived mononuclear cells (monocytes/T cells). Myoglobin significantly increased (p<0.05) at 1 h post-contest, neopterin significantly increased at 1 and 24 h (p<0.05), total neopterin significantly increased (p<0.05) at 1 h post for the passive group only, and significant individual variation was observed for all markers (p<0.01). Cold water immersion attenuated total neopterin production (p<0.05), while cryotherapy significantly reduced total neopterin production in PMA-stimulated mononuclear cells (p<0.01). Cryotherapy attenuates the post-exercise inflammatory response following an MMA contest. The evidence also suggests that the mechanisms responsible for this may be related to direct immune cell suppression.

Journal

Pteridines – de Gruyter

Published: Dec 1, 2015

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    Takeda
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    Jakeman
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    Fragala
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    Choo
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    McGorm
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    Sutkowy
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    Kharraz
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    Roberts LA
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    Spath
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    Broatch
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    Smart
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    Costello
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    Goldberger
  • Protein ingestion before sleep improves postexercise overnight recovery
    Groen
  • Amtmann Amtmann Lactate and rate of perceived exertion responses of athletes training for and competing in a mixed martial arts event
    Spath
  • Physical exercise combined with whole - body cryotherapy in evaluating the level of lipid peroxidation products and other oxidant stress indicators in kayakers Oxid
    Sutkowy
  • Inhibition of haemolysis by the macrophage synthesized antioxidant dihydroneopterin
    Gieseg
  • The relationship between changes in interstitial creatine kinase and game - related impacts in rugby union
    Smart
  • Effectiveness of post - match recovery strategies in rugby players
    Gill
  • MS AR AM LP receptor expression during muscle recovery
    Fragala
  • Cold water immersion and recovery from strenuous exercise : a meta - analysis
    Leeder
  • Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow - mediated dilation in healthy humans
    Rakobowchuk
  • Cardiovascular regulation during water immersion Human
    Park
  • Impact - induced muscle damage and urinary pterins in professional rugby dihydroneopterin oxidation by myoglobin
    Lindsay
  • Measurement of changes in urinary neopterin and total neopterin in body builders using SCX
    Lindsay
  • MAP Cryotherapy post - training reduces muscle damage markers in jiu - jitsu fighters
    Santos
  • Cold water immersion enhances recovery of submaximal muscle function after resistance exercise
    Roberts LA
  • Dissociation of neopterin dihydroneopterin from plasma components before HPLC analysis
    Flavall
  • Hematological and biochemical markers after a tournament in world - class athletes Bras
    Brandao
  • Dissociation of neopterin dihydroneopterin from plasma components before HPLC analysis
    Flavall