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Summary The concentration of folylpolyglutamates in liver is 10 - 20 µmol/kg tissue. This concentration is approached by that of the folate-binding sites of several enzymes involved in 1-carbon metabolism, suggesting that a large proportion of cellular folates is protein-bound. Glycine N-methyltransferase and 10-formyl-H 4 PteGlu dehydrogenase have been identified as "folate binding proteins" because of their strong affinity for folylpolyglutamates during gel chromatography. Serine hydroxymethyltransferase may also prove to be a “folate binding protein.” Although the folate-binding properties of the above proteins in vivo remain virtually untested, it is likely that the proteins have an effect on the activities of other folate-requiring enzymes, such as thymidylate synthase.
Pteridines – de Gruyter
Published: Aug 1, 1989
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