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The Influence of Folate Binding Proteins on 1-Carbon Metabolism A Review

The Influence of Folate Binding Proteins on 1-Carbon Metabolism A Review Summary The concentration of folylpolyglutamates in liver is 10 - 20 µmol/kg tissue. This concentration is approached by that of the folate-binding sites of several enzymes involved in 1-carbon metabolism, suggesting that a large proportion of cellular folates is protein-bound. Glycine N-methyltransferase and 10-formyl-H 4 PteGlu dehydrogenase have been identified as "folate binding proteins" because of their strong affinity for folylpolyglutamates during gel chromatography. Serine hydroxymethyltransferase may also prove to be a “folate binding protein.” Although the folate-binding properties of the above proteins in vivo remain virtually untested, it is likely that the proteins have an effect on the activities of other folate-requiring enzymes, such as thymidylate synthase. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

The Influence of Folate Binding Proteins on 1-Carbon Metabolism A Review

Pteridines , Volume 1 (3) – Aug 1, 1989

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Publisher
de Gruyter
Copyright
Copyright © 1989 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pteridines.1989.1.3.159
Publisher site
See Article on Publisher Site

Abstract

Summary The concentration of folylpolyglutamates in liver is 10 - 20 µmol/kg tissue. This concentration is approached by that of the folate-binding sites of several enzymes involved in 1-carbon metabolism, suggesting that a large proportion of cellular folates is protein-bound. Glycine N-methyltransferase and 10-formyl-H 4 PteGlu dehydrogenase have been identified as "folate binding proteins" because of their strong affinity for folylpolyglutamates during gel chromatography. Serine hydroxymethyltransferase may also prove to be a “folate binding protein.” Although the folate-binding properties of the above proteins in vivo remain virtually untested, it is likely that the proteins have an effect on the activities of other folate-requiring enzymes, such as thymidylate synthase.

Journal

Pteridinesde Gruyter

Published: Aug 1, 1989

There are no references for this article.