Access the full text.
Sign up today, get DeepDyve free for 14 days.
W. Aulitzky, J. Frick, D. Fuchs, A. Hausen, G. Reibnegger, H. Wachter (1985)
Significance of urinary neopterin in patients with malignant tumors of the genitourinary tractCancer, 55
Neopterin excretion during incubation period , clinical manifestation and reconvalescence of Pteridines I Vo ! ' 10 I No . 3 viral infection
(1990)
Nishanian 1 ~ Giorgi JV 11 K prognostic value of cellular and serological markers in infection with human immunodeficiency vims type 1 . N . Eng ! . ]
(1989)
Fuel ) ' ; D . H . 1 UScn A , Schmutzhard E , Wachter H . Urinary neoptcrin is elevated in patients with malaria
(1994)
Interleron - gamma - induced fC : Jrmation of neopterin and degradation of tryptophan in cerebrospinal fluid of children with meningitis but not with febrilc comrul - sions
(1989)
nary neopterin as a prognostic marker in haematological neoplasias
C. Murr, L. Fuith, B. Widner, B. Wirleitner, G. Baier‐Bitterlich, D. Fuchs (1999)
Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?Anticancer research, 19 3A
A. Hausen, C. Aichberger, A. Königsrainer, G. Weiss, R. Margreiter, H. Wachter (1993)
Biliary and urinary neopterin concentrations in monitoring liver-allograft recipients.Clinical chemistry, 39 1
(1995)
Semm neopterin concentrations in chronic li ver disease
P. Kronberger, G. Weiss, J. Tschmelitsch, D. Fuchs, G. Salzer, H. Wachter, G. Reibnegger (1995)
Predictive Value of Urinary Neopterin in Patients with Lung Cancer, 33
C. Ricci, E. Minetto, G. Cascio, A. Anania, P. Omedè, E. Valente (1979)
[Immunity in sarcoidosis].Recenti progressi in medicina, 67 1
(1989)
Tumor necrosis factor - alpha and lipopolysaccharide enhance interferon - induced tryptophan dcgradation and pteridine syntl 1 esis in human cells
(1982)
Determi - nation of neopterin in human urine by reversed - pase high - performance liquid chromatography "
M. Samsonov, Dietmar Fuchs, Gilbert Reibnegger, J. Belenkov, E. Nassonov, H. Wachter (1992)
Patterns of serological markers for cellular immune activation in patients with dilated cardiomyopathy and chronic myocarditis.Clinical chemistry, 38 5
D. Griffin, B. Ward, B. Ward, Enrique Jauregui, Enrique Jauregui, Richard Johnson, A. Vaisberg, A. Vaisberg (1990)
Immune activation during measles: interferon-gamma and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease.The Journal of infectious diseases, 161 3
D. Fuchs, G. Baier‐Bitterlich, I. Wede, H. Wachter (1997)
Reactive Oxygen and ApoptosisCold Spring Harbor Monograph Archive, 34
P. Mayersbach, R. Augustin, H. Schennach, D. Fuchs, E. Werner, D. Schonitzer, H. Wachter, G. Reibnegger (1994)
Applicability of an Enzyme-linked Immunosorbant Assay for Neopterin Detection for Screening of Blood Donations, 5
Dietmar Fuchs, A. Hausen, G. Reibnegger, E. Werner, M. Dierich, H. Wachter (1988)
Neopterin as a marker for activated cell-mediated immunity: application in HIV infection.Immunology today, 9 5
D. Fuchs, A. Hausen, G. Reibnegger, E. Werner, P. Dittrich, H. Wachter (1988)
Neopterin levels in long-term hemodialysis.Clinical nephrology, 30 4
L. Leohirun, P. Thuvasethakul, V. Sumethkul, T. Pholcharoen, V. Boonpucknavig (1991)
Urinary neopterin in patients with systemic lupus erythematosus.Clinical chemistry, 37 1
(1984)
Raised serum levels and imbalances of T - lymphocyte subsets in viral diseases , aquired immune ddiciency and related lymphadenopathy syndromes
Ko tler . ~ L 1 ' . m . lt ) o \ \ · , ki H , Reib - ncggcr G . \ \ ' achrer H . ~ c { ) ptlTi n . l ' . lt ) indc : \ ofil 1 ll 11 ul 1 e response in parienrs \ \ - i rh ntL ' < . Tculmis
(1991)
Markers of disease progression in intra \ " ( : nous drug users infected with H 1 V - 1
P. Fei, António Massa, G. Prignano, M. Pietravalle, L. Alemanno, G. Vitelli, G. Palamara, A. Giglio, G. Gandolfo, G. Gentili (1992)
Behaviour of several 'progression markers' during the HIV-Ab seroconversion period. Comparison with later stages.Journal of biological regulators and homeostatic agents, 6 2
G. Reibnegger, A. Bichler, O. Dapunt, D. Fuchs, L. Fuith, A. Hausen, H. Hetzel, H. Lutz, E. Werner, H. Wachter (1986)
Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix.Cancer research, 46 2
(1987)
Clinical presentation of CMV infection in solid org ~ U 1 transplant recipients and its impact on graft rejection and neopterin excretion . C 1 in
(1997)
C hronic imn 1 Ulle stimulatio n , oxidative stress , and apoprosis in HIV infection
D. Zaknun, G. Weiss, J. Glatzl, H. Wachter, D. Fuchs (1993)
Neopterin levels during acute rubella in children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 17 3
Barbara Reinhardt, R. Jaspert, M. Niedrig, C. Kostner, J. L'age‐Stehr (1998)
Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: A model of human flavivirus infectionJournal of Medical Virology, 56
(1995)
~ Gupta P Quamit ' ltiu ! 1 of HI \ , - l R ~ A in plasma predicts o utcome aftet · SLToco tl \ · ersion
(1989)
~ eopterin as apre - dictive marker for disease progression in hWl 1 an immu - noddiciency virus type 1 infection
(1997)
Lack o f associations of chemotactic cvtokines with viral burden , disease progression , or lymphoc \ Te subsets in HIV - infected individuals
L. Dotevall, Dietmar Fuchs, G. Reibnegger, H. Wachter, L. Hagberg (1990)
Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosisInfection, 18
(1987)
Early predictive vallie of urinary neopterin in kidney transplant rejection
M. Samsonov, E. Nassonov, G. Tilz, B. Geht, U. Demel, G. Gurkina, Shtutman Vz, A. Guseva, H. Wachter, Dietmar Fuchs (1997)
Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis.British journal of rheumatology, 36 6
A. Lewenhaupt, P. Ekman, P. Eneroth, A. Eriksson, B. Nilsson, L. Nordström (1986)
Serum levels of neopterin as related to the prognosis of human prostatic carcinoma.European urology, 12 6
(1988)
Urinary neopterin levcIs in acute and viral hepatitis
D. Fuchs, G. Granditsch, A. Hausen, G. Reibnegger, H. Wachter (1983)
URINARY NEOPTERIN EXCRETION IN COELIAC DISEASEThe Lancet, 322
D. Fuchs, A. Hausen, G. Reibnegger, E. Werner, G. Werner-Felmayer, H. Wachter (1990)
Distinct Neopterin Excretion Patterns after Vaccination, 2
B. Widner, G. Baier‐Bitterlich, I. Wede, B. Wirleitner, H. Wachter, D. Fuchs (1998)
N eopterin: Indicator of Oxidative Stress and Part of the Cytotoxic Armature of Activated Macrophages in Humans, 9
(1991)
DiHerential diagnosis of transplant fi . 111 c - tion disorders in therapy with monoclonal antibodies OKT 3
(1986)
Urinary neopterin rdeJects clinical activity in patients wich rheumatoid arthritis
D. Niederwieser, D. Fuchs, A. Hausen, G. Judmaier, G. Reibnegger, H. Wachter, C. Huber (1985)
Neopterin as a new biochemical marker in the clinical assessment of ulcerative colitis.Immunobiology, 170 4
(1993)
Macrophage activation in falcipanlm maLuia as mea ~ urcd by neo pterin and interferon gamma
(1989)
HIV antigen smdv . Beitr
H. Schennach, D. Schoenitzer, D. Fuchs (1998)
Association between chronic hepatitis C virus infection and increased neopterin concentrations in blood donations.Clinical chemistry, 44 10
M. Havel, A. Laczkovics, H. Teufelsbauer, M. Müller, E. Wolner (1989)
Neopterin as a new marker to detect acute rejection after heart transplantation.The Journal of heart transplantation, 8 2
R. Margreiter, D. Fuchs, A. Hausen, C. Huber, G. Reibnegger, M. Spielberger, H. Wachter (1983)
Neopterin as a new biochemical marker for diagnosis of allograft rejection. Experience based upon evaluation of 100 consecutive cases.Transplantation, 36 6
(1984)
ltnmune response-associated production of neopterin. Releasc from macrophages primarily lU1der control of interferon ga.mma
C. Murr, Jens Berchtold, Burghard Norer, E. Waldhart, H. Wachter, Dietmar Fuchs (1998)
Neopterin as a prognostic parameter in patients with squamous‐cell carcinomas of the oral cavityInternational Journal of Cancer, 79
(1989)
Serum - Neopterin Bestimmung zur zusat - zlichen Sicherung der Bluttransfusion
G. Reibnegger, Claudia Aichberger, D. Fuchs, A. Hausen, M. Spielberger, E. Werner, R. Margreiter, Helmut Wachtehr (1991)
POSTTRANSPLANT NEOPTERIN EXCRETION IN RENAL ALLOGRAFT RECIPIENTS—A RELIABLE DIAGNOSTIC AID FOR ACUTE REJECTION AND A PREDICTIVE MARKER OF LONG‐TERM GRAFT SURVIVALTransplantation, 52
(1995)
erythe - matosus
H. Gaines, M. Sydow, L. Stedingk, G. Biberfeld, B. Böttiger, L. Hansson, P. Lundbergh, A. Sönnerborg, J. Wasserman, Ö. Strannegård (1990)
Immunological changes in primary HIV‐1 infectionAIDS, 4
A. Brown, D. Dance, W. Chaowagul, H. Webster, N. White (1990)
Activation of cellular immune responses in melioidosis patients as assessed by urinary neopterin.Transactions of the Royal Society of Tropical Medicine and Hygiene, 84 4
S. Clark, M. Saag, W. Decker, Sherri Campbell-Hill, Joseph Roberson, P. Veldkamp, J. Kappes, B. Hahn, G. Shaw (1991)
High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection.The New England journal of medicine, 324 14
Günter Weiss, C. Murr, Heinz Zoller, Margot Haun, B. Widner, C. Ludescher, Dietmar Fuchs (1999)
Modulation of neopterin formation and tryptophan degradation by Th1‐ and Th2‐derived cytokines in human monocytic cellsClinical & Experimental Immunology, 116
(1994)
Transient high levels of viremia in patients with primary human immunodeficiency vims type I infection . ; - : I . Eng !
A. Fauci (1988)
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.Science, 239 4840
A. Krämer, R. Biggar, H. Hampl, R. Friedman, Dietmar Fuchs, H. Wachter, J. Goedert (1992)
Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific.American journal of epidemiology, 136 1
B. Halliwell, M. Murcia, Susanna Chirico, O. Aruoma (1995)
Free radicals and antioxidants in food and in vivo: what they do and how they work.Critical reviews in food science and nutrition, 35 1-2
Melmed Rn, Jeremy Taylor, R. Detels, M. Bozorgmehri, J. Fahey (1989)
Serum neopterin changes in HIV-infected subjects: indicator of significant pathology, CD4 T cell changes, and the development of AIDS.Journal of acquired immune deficiency syndromes, 2 1
(1987)
Clinical presentation of CM V infection in solid organ transplant recipients and its impact on graft rejection and neopterin excretion Clin
(1984)
Elevated mmo r necrosis factor alpha and interleukin - 6 Sen 1 ! 11 levels as markers for complicated Plasmodium falciparum malaria
(1987)
Detennination of neopterin in serum and urine
T. Iizuka, Y. Minatogawa, Hiroshi Suzuki, M. Itoh, S. Nakamine, Y. Hatanaka, S. Uemura, M. Koike (1993)
Urinary neopterin as a predictive marker of coronary artery abnormalities in Kawasaki syndrome.Clinical chemistry, 39 4
H. Wachter, Dietmar Fuchs, A. Hausen, G. Reibnegger, E. Werner (1989)
Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application.Advances in clinical chemistry, 27
(1994)
Increased prevalence of IgM antibodies to Epstein - Barr virus and parvovirus B 19 in blood don , uions \ \ · ith above normal neopterin con - cemr ~ ltiol 1 S . Clin
G. Hussey, E. Goddard, J. Hughes, J. Ryon, M. Kerran, E. Carelse, P. Strebel, L. Markowitz, J. Moodie, P. Barron, Z. Latief, R. Sayed, D. Beatty, D. Griffin (1996)
The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune response in infants.The Journal of infectious diseases, 173 6
(1999)
Inverse relationship benveen alpha - tocopherol and l 1 eopterin concentrations in cerebrospinal fluid of patients with dementia
(1994)
Incrcased urinary neoptcrin in acute myocardial infarction
A. Königsrainer, G. Reibnegger, D. Ofner, G. Klima, T. Tauscher, R. Margreiter (1990)
Pancreatic juice neopterin excretion--reliable marker for detection of pancreatic allograft rejection.Transplantation proceedings, 22 2
D. Fuchs, M. Banekovich, A. Hausen, J. Hutterer, G. Reibnegger, E. Werner, F. Gschnait, M. Dierich, H. Wachter (1988)
Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1.Clinical chemistry, 34 12
H. Kawasaki, H. Watanabe, S. Yamada, K. Watanabe, A. Suyama (1988)
Prognostic significance of urinary neopterin levels in patients with hepatocellular carcinoma.The Tohoku journal of experimental medicine, 155 4
D. Niederwieser, C. Huber, A. Gratwohl, P. Bannert, D. Fuchs, A. Hausen, G. Reibnegger, B. Speck, H. Wachter (1984)
NEOPTERIN AS A NEW BIOCHEMICAL MARKER IN THE CLINICAL MONITORING OF BONE MARROW TRANSPLANT RECIPIENTSTransplantation, 38
G. Reibnegger, H. Hetzel, D. Fuchs, L. Fuith, A. Hausen, E. Werner, H. Wachter (1987)
Clinical significance of neopterin for prognosis and follow-up in ovarian cancer.Cancer research, 47 18
\ \ ' achter H . : - ' : eopterin formation and tn ' prophan degradation b \ ' a human myelol 11 onocytic ceU line ( THP - l )
(1988)
Relationship between semm neopterin and lymphocytic alveoli tis in
G. Maerker-alzer, O. Diemer, R. Strümper, M. Rohe (2004)
Neopterin production in inflamed knee joints: high levels in synovial fluidsRheumatology International, 6
L. Hagberg, L. Dotevall, G. Norkrans, M. Larsson, H. Wachter, Dietmar Fuchs (1993)
Cerebrospinal fluid neopterin concentrations in central nervous system infection.The Journal of infectious diseases, 168 5
(1997)
Neopterin , b 2 - microglob - ulin . , md the acute phase proteins in HIV - l seropos itive , 1 Ild seronegative Zambian patients with mberculosis
(1988)
. I - iver involvement in human schist < lsol 11 iasis mansoni . Assessment bv immuno logical and biochemical m ' lrkers . Par , lsirol . Res .
J. Popov, T. McGraw, B. Hofmann, B. Vowels, A. Shum, P. Nishanian, J. Fahey (1992)
Acute lymphoid changes and ongoing immune activation in SIV infection.Journal of acquired immune deficiency syndromes, 5 4
(1979)
Erh ( . > hte Auss - cheidung von Neopterin im Harn von Patienten mit malignen TlU 110 ren lmd mit Viruserkrankungen . Hoppe - Seylers Z . Physio !
(1986)
A simple index relating clinical activit \ " in Crolms disease with T - cell activation : Hematokrit , frequency of liquid stools an urinary neoptcrin as par ' 1 Il 1 eters
(1992)
Earl \ - changes of ne ( lptcrin \ . · OIKentr , l - tions during treatment of human immul 1 oddicienC \ ' vints . infection with zido \ " lldine
(1995)
Semm - soluble reccptors fix um 10 r necrosis factor - alpha and intcrleukin - 2 , and neopterin in acute rheumatic fever
(1990)
Clinical resolve - ment of m alaria infection parallels decrease of high ' " elevated sen . lm neopterin level
(1997)
Senlm concentrations of neopterin , soluble interleukin - 2 receptor , and soluble TNB - receptor in Wegeners granulomatosis
(1989)
Association hetween serum neopterin concentration and in vitro replicative capacity HIV - l isolates . 1
(1999)
Are dentritic cells a relevant source of neopterin production in clinical conditions
R. Zangerle, D. Schönitzer, D. Fuchs, J. Möst, M. Dierich, H. Wachter (1992)
Reducing HIV transmission by seronegative bloodThe Lancet, 339
J. Andersson, S. Nagy, Groth Cg, U. Andersson (1992)
Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level.Immunology, 75 1
Summary Neopterin is produced and secreted in large amounts by interferon-g stimulated human monocytes/macrophages. Neopterin measurement in urine and semm provides a usefi.ll possibility to estimate the dcgree of ccllular (Thl-type) immune activation, which is directed against viral infections, intracellular bacteria, and certain parasites. Also in malignancy, autoimmw1e diseases and allograft rejection episodes neopterin sensitively reflects the extent of cellular immune activation. Determination of neoptcrin concentrations can be conveniently performed by immunoassay like ELISA or RIA, and HPLC. The major diagnostic applications of neopterin monitoring are: surveillancc of the immw1e status of organ recipients, therapy control and prognosis of diseasc progression in tumor diseascs and HIV infections and also detection of unknown infections in e.g. blood banks. High neopterin levels are strongly associated with oxidative stress, opening an additional application field of ncopterin monitoring to estimate the extent of tissue damagc in the course of immune activation.
Pteridines – de Gruyter
Published: Aug 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.