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The high-risk HPV infection and urinary system tumor

The high-risk HPV infection and urinary system tumor AbstractHPV is classified into high-risk and low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the infection caused by the high-risk type, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection International de Gruyter

The high-risk HPV infection and urinary system tumor

Yang, Wenyan
Infection International , Volume 6 (4): 4 – Apr 10, 2018
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References (27)

Publisher
de Gruyter
Copyright
© 2017 Walter de Gruyter GmbH, Berlin/Boston
eISSN
2544-0349
DOI
10.2478/ii-2018-0004
Publisher site
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Abstract

AbstractHPV is classified into high-risk and low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the infection caused by the high-risk type, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.

Journal

Infection International – de Gruyter

Published: Apr 10, 2018

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