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Synthesis of madecassic acid derivatives and their cytotoxic activity

Synthesis of madecassic acid derivatives and their cytotoxic activity AbstractFifteen new 28-amide derivatives of madecassic acid, isolated from the tropical medicinal herb Centella asiatica (Apiaceae), have been synthesised, and their cytotoxicity on three cancer cell lines, KB (carcinoma cancer), HepG2 (liver cancer) and Lu-1 (lung cancer), was evaluated. The results showed that acetylation of the 2,3,23-hydroxyl group and/or amidation of the 28-COOH group strongly increased the cytotoxicity of the synthesised compounds. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Naturforschung B de Gruyter

Synthesis of madecassic acid derivatives and their cytotoxic activity

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References (14)

Publisher
de Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
0932-0776
eISSN
1865-7117
DOI
10.1515/znb-2017-0172
Publisher site
See Article on Publisher Site

Abstract

AbstractFifteen new 28-amide derivatives of madecassic acid, isolated from the tropical medicinal herb Centella asiatica (Apiaceae), have been synthesised, and their cytotoxicity on three cancer cell lines, KB (carcinoma cancer), HepG2 (liver cancer) and Lu-1 (lung cancer), was evaluated. The results showed that acetylation of the 2,3,23-hydroxyl group and/or amidation of the 28-COOH group strongly increased the cytotoxicity of the synthesised compounds.

Journal

Zeitschrift für Naturforschung Bde Gruyter

Published: Feb 23, 2018

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