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Synthesis and antibacterial activity
- Publisher
- de Gruyter
- Copyright
- ©2016 by De Gruyter
- ISSN
- 0932-0776
- eISSN
- 1865-7117
- DOI
- 10.1515/znb-2016-0043
- Publisher site
- See Article on Publisher Site
Abstract
AbstractA selected set of N1-(4-chloro-9-ethylcarbazol-3-yl)amidrazones (7a–n) has been synthesized by reacting the respective hydrazonoyl chloride 5 derived from 3-amino-9-ethylcarbazole (3), with an appropriate sec-cyclic amine (6a–n) in ethanol in the presence of triethylamine. Unexpectedly, aromatic ring chlorination occurred at C-4 of 3 during its conversion to 6 as evidenced by analytical and spectral data and further confirmed by single crystal X-ray structure determination of the amidrazone 7n. Compounds 7a–n were tested for their in vitro antibacterial activity. Among the tested bacterial strains, methicillin-resistant Staphylococcus aureus was the most susceptible to 7f and Bacillus cereus to 7b both with a minimum inhibitory concentration value of 1.56 µg mL−1. Compounds 7c, 7f, and 7h could be useful as lead structures for further development of new antibacterial agents against Gram-positive and Gram-negative pathogens.
Journal
Zeitschrift für Naturforschung B – de Gruyter
Published: Aug 1, 2016