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E. Werner, A. Bichler, G. Daxenbichler, D. Fuchs, Fuith Lc, A. Hausen, H. Hetzel, G. Reibnegger, H. Wachter (1987)
Determination of neopterin in serum and urine.Clinical chemistry, 33 1
Stephen Feman, Robert Mericle, George Reed, James May, Robert Workman (1993)
Serum angiotensin converting enzyme in diabetic patients.The American journal of the medical sciences, 305 5
G. Reibnegger, H. Hetzel, D. Fuchs, L. Fuith, A. Hausen, E. Werner, H. Wachter (1987)
Clinical significance of neopterin for prognosis and follow-up in ovarian cancer.Cancer research, 47 18
G. Reibnegger, Dietmar Fuchs, Fuith Lc, A. Hausen, E. Werner, G. Werner-Felmayer, H. Wachter (1991)
Neopterin as a marker for activated cell-mediated immunity: application in malignant disease.Cancer detection and prevention, 15 6
H. Neels, M. Sande, S. Scharpe (1983)
Sensitive colorimetric assay for angiotensin converting enzyme in serum.Clinical chemistry, 29 7
G. Reibnegger, A. Bichler, O. Dapunt, D. Fuchs, L. Fuith, A. Hausen, H. Hetzel, H. Lutz, E. Werner, H. Wachter (1986)
Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix.Cancer research, 46 2
J. Lieberman (1975)
Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis.The American journal of medicine, 59 3
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Roe of angiotensin - converting enzyme in Bacille Calmette - Guerin - induced granulomatous inflammation ]
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Angiotensin-converting enzyme and its clinical significance--a review.Journal of Clinical Pathology, 36
(1992)
Serum angiotensinconverting enzyme level is elevated in patients with human immunodeficiency viru s infection
Dietmar Fuchs, Hans Jäger, Matei Popescu, Gilbert Reibnegger, E. Werner, M. Dierich, Werner Kaboth, G. Tilz, H. Wachter (1990)
Immune activation markers to predict AIDS and survival in HIV-1 seropositives.Immunology letters, 26 1
(1993)
Serum angiotensin converting enzyme activity in Crohn ' s disease and ulcerative colitis . Ital . ]
A. Bhigjee, N. Pillay, M. Omar, P. Naidoo, D. Hariparsad (1980)
Serum angiotensin-converting enzyme in sarcoidosis.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 58 15
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Serum angiotensin converting enzyme activity in Crohn's disease and ulcerative colitis.The Italian journal of gastroenterology, 25 1
H. Wachter, Dietmar Fuchs, A. Hausen, G. Reibnegger, E. Werner (1989)
Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application.Advances in clinical chemistry, 27
Dapunt 0 , Fuchs D , Fuith LC , Hausen A , Hetzel H .
C. Huber, J. Batchelor, D. Fuchs, A. Hausen, A. Lang, D. Niederwieser, G. Reibnegger, P. Swetly, J. Troppmair, H. Wachter (1984)
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gammaThe Journal of Experimental Medicine, 160
D. Niederwieser, D. Fuchs, A. Hausen, G. Judmaier, G. Reibnegger, H. Wachter, C. Huber (1985)
Neopterin as a new biochemical marker in the clinical assessment of ulcerative colitis.Immunobiology, 170 4
Dietmar Fuchs, A. Hausen, G. Reibnegger, E. Werner, M. Dierich, H. Wachter (1988)
Neopterin as a marker for activated cell-mediated immunity: application in HIV infection.Immunology today, 9 5
(1983)
Angiotens in - converting enzyme and its clinical significance - a review . 1
Summary An elevation of serum angiotensin-converting enzyme (ACE) has been reported in some disorders associated with immune activation, e.g. sarcoidosis, HIV infection or ulcerative colitis. Both endothelial cells and macrophages are thought to be the possible source of increased ACE levels. We have investigated serum ACE and neopterin, an indicator of macrophage activation, in 23 patients with solid tumors as well as in 8 controls. Similar ACE levels have been observed in the cancer patients and the controls (2.6 ± 2.1 vs 3.4 ± 1.1 μkat/1, while neopterin has been significantly higher in the cancer patients (15.4 ± 12.6 vs 7.2 ± 2.2 nmol/I, P<O.02). No correlation has been observed between serum ACE and neopterin. We conclude that an elevation of ACE is not present in cancer patients. Macrophage activation in cancer is not accompanied by increased ACE release.
Pteridines – de Gruyter
Published: Nov 1, 1994
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