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J. Casals-Sánchez, M. Prous, Miguel Gallego, Juan Olmos, Loreto Ortells, Cesar García (2012)
Characteristics of patients with spondyloarthritis followed in rheumatology units in Spain. emAR II study.Reumatologia clinica, 8 3
R. Peluso, S. Iervolino, M. Vitiello, V. Bruner, G. Lupoli, M. Minno (2015)
Extra-articular manifestations in psoriatic arthritis patientsClinical Rheumatology, 34
B. Widemann, P. Adamson (2006)
Understanding and managing methotrexate nephrotoxicity.The oncologist, 11 6
T. Shigehara, Concepción Zaragoza, C. Kitiyakara, Hideko Takahashi, Huiyan Lu, M. Moeller, L. Holzman, J. Kopp (2003)
Inducible podocyte-specific gene expression in transgenic mice.Journal of the American Society of Nephrology : JASN, 14 8
Rodrigues (2012)
Low prevalence of renal cardiac pulmonary and neurological extra - articular clinical manifestations in spondyloarthritis : analysis of the Brazilian Registry of SpondyloarthritisRev Bras Reumatol, 11
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Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death
H. Chiu, H-L. Huang, C-H Li, Yun-Ju Yin, H.A. Chen, S. Hsu, S‐J. Lin, T. Tsai, Shinn-Ying Ho (2015)
Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population‐based cohort studyBritish Journal of Dermatology, 173
C. Pană, L. Tuta, Loredana Pazara, M. Șuța (2015)
SP426ASSOCIATION BETWEEN INFLAMMATION AND RENAL INVOLVEMENT IN PSORIATIC ARTHRITISNephrology Dialysis Transplantation, 30
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Understanding and managing methotrexate
S. Feldman, Yang Zhao, Lizheng Shi, M. Tran, Jackie Lu (2015)
Economic and Comorbidity Burden Among Moderate‐to‐Severe Psoriasis Patients with Comorbid Psoriatic ArthritisArthritis Care & Research, 67
C. Chi, Jui Wang, Yu-Fen Chen, Shu-hui Wang, Fu-Li Chen, T. Tung (2015)
Risk of incident chronic kidney disease and end-stage renal disease in patients with psoriasis: A nationwide population-based cohort study.Journal of dermatological science, 78 3
C. Chi, J. Wang, Y. Chen, S. Wang, F. Chen, T. Tung (2015)
Risk of Incident Chronic Kidney Disease and End-Stage Renal Disease in Patients with Psoriasis: a Nationwide Population-Based Cohort Study.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 18 7
A. Ogdie, S. Schwartzman, M. Husni (2015)
Recognizing and managing comorbidities in psoriatic arthritisCurrent Opinion in Rheumatology, 27
C. Rodrigues, W. Vieira, A. Bortoluzzo, C. Gonçalves, José Silva, A. Ximenes, M. Bértolo, S. Ribeiro, M. Keiserman, R. Menin, T. Skare, S. Carneiro, V. Azevedo, E. Albuquerque, W. Bianchi, R. Bonfiglioli, C. Campanholo, H. Carvalho, I. Costa, A. Duarte, C. Kohem, N. Leite, Sonia Lima, E. Meirelles, I. Pereira, M. Pinheiro, E. Polito, G. Resende, F. Rocha, M. Santiago, M. Sauma, V. Valim, P. Sampaio-Barros (2012)
Baixa prevalência das manifestações extra-articulares renais, cardíacas, pulmonares e neurológicas nas espondiloartrites: análise do Registro Brasileiro de EspondiloartritesRevista Brasileira De Reumatologia, 52
J. Casals-Sánchez, M. Prous, Miguel Gallego, Juan Olmos, Loreto Ortells, Cesar García (2012)
Characteristics of Patients With Spondyloarthritis Followed in Rheumatology Units in Spain. emAR II StudyReumatología Clínica, 8
D. Keith, G. Nichols, C. Gullion, Jonathan Brown, David Smith (2004)
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A. Ogdie, S. Schwartzman, L. Eder, A. Maharaj, D. Zisman, S. Raychaudhuri, S. Reddy, E. Husni (2014)
Comprehensive Treatment of Psoriatic Arthritis: Managing Comorbidities and Extraarticular ManifestationsThe Journal of Rheumatology, 41
J. Baker, E. Krishnan, Lan Chen, H. Schumacher (2005)
Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?The American journal of medicine, 118 8
R. Foley, Anne Murray, Shuling Li, C. Herzog, A. McBean, P. Eggers, A. Collins (2005)
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G. Alenius, Bernd Stegmayr, S. Dahlqvist (2001)
Renal abnormalities in a population of patients with psoriatic arthritis.Scandinavian journal of rheumatology, 30 5
Abstract Introduction. Psoriatic arthritis (PA) is a multi-system inflammatory disorder that involves both musculoskeletal structures (joints, enthesis, tendons) and the skin and nails (psoriasis). Clinical manifestations can be varied from clinically asymptomatic disease to arthritis mutilans and invalidating forms. Purpose. Identification of renal disease in patients with psoriatic arthritis depending on the degree of activity and severity of skin and joint disease. Material and Methods. We conducted a retrospective study of 89 patients diagnosed with psoriatic arthritis in the Rheumatology Department of Clinical Emergency Hospital “Sf. Andrei” in Constanta. We collected demographic and behavioural data (age, sex, ethnicity, smoking), clinical and biological elements of joint and skin disease activity (number of painful and swollen joints, joint pain score - VAS, PASI score, ESR, CRP) and evaluation of renal function (serum creatinine, serum uric acid, urinalysis examination for proteinuria and hematuria). Chronic kidney disease was staged by calculating the value of glomerular filtration rate (GFR) with CKD-EPI 2009 equation. Results. 49 patients have full screening of renal function, especially in disease onset or in case of therapy switch. Proteinuria was found in a significant percentage of patients (32.65%), vary widely between 10-500 mg/dL. Chronic kidney disease (CKD) was commonly found in our patients (42.85%), mostly in women (66.6%). Most cases of CKD were in stage 2 (12.4%). We observed a significant correlation between age and levels of serum creatinine (p = 0.041), caucasians developing more frequently CKD (p <0.0001). The presence of skin psoriasis did not interfere with renal function decline in PA patients, but its severity, measured with PASI score, was correlated with cronic kidney failure stages (p = 0.05) and proteinuria (p = 0.044). The severity of joint pain (TJC, VAS) is directly related to kidney disease (p <0.0001, respectively p = 0.05). The majority of patients with extensive joint erosions also had renal impairment (p = NS) and it can be seen a direct correlation between erosive joint disease and serum creatinine (p = 0.029). Conclusions: Both the severity of psoriasis and articular disease may be involved in worsening of renal function, probably due to the chronic systemic inflammation and to an aggressive therapy imposed by the disease evolution.
ARS Medica Tomitana – de Gruyter
Published: Feb 1, 2016
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