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Relationship among Serum hsp65 Antibodies, Neopterin, Autoantibodies and Atherosclerosis

Relationship among Serum hsp65 Antibodies, Neopterin, Autoantibodies and Atherosclerosis Summary A statistical reinvestigation was performed on data from two separate earlier studies, investigating heatshock protein 65 and neopterin in the same population of subjects examined for the presence of carotid atherosclerosis. Both heat-shock protein 65 and neopterin concentrations are significantly correlated with atherosclerosis, but the correlation between both biochemical analytes is low albeit significant. Neopterin, but not heat-shock protein 65 concentrations were shown to be significantly higher in women with presence of antinuclear antibodies, particularly in women older than 65 years of age. This finding seems to explain earlier observations of raised neopterin concentrations in such older women, irrespective of the presence or absence of atherosclerosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Relationship among Serum hsp65 Antibodies, Neopterin, Autoantibodies and Atherosclerosis

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Publisher
de Gruyter
Copyright
Copyright © 1994 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pteridines.1994.5.4.139
Publisher site
See Article on Publisher Site

Abstract

Summary A statistical reinvestigation was performed on data from two separate earlier studies, investigating heatshock protein 65 and neopterin in the same population of subjects examined for the presence of carotid atherosclerosis. Both heat-shock protein 65 and neopterin concentrations are significantly correlated with atherosclerosis, but the correlation between both biochemical analytes is low albeit significant. Neopterin, but not heat-shock protein 65 concentrations were shown to be significantly higher in women with presence of antinuclear antibodies, particularly in women older than 65 years of age. This finding seems to explain earlier observations of raised neopterin concentrations in such older women, irrespective of the presence or absence of atherosclerosis.

Journal

Pteridinesde Gruyter

Published: Nov 1, 1994

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