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Protective Effect of Ranopterin Neopterin on Experimentally Induced Graffi Tumours in Hamsters

Protective Effect of Ranopterin Neopterin on Experimentally Induced Graffi Tumours in Hamsters Zvetkova et at.: Protective effect of ranopterin nenpterin Pteridines Vol. 9, 1998, pp. 196 - 200 Protective Effect of Ranopterin Neopterin on Experimentally Induced GrafE Tumours in Hamsters E. Zvetkova 1 §, R. Toshkova\ V. Ralchevsky\ A . Dikov\ E. Katzarova\ 1. Chowdhury! and 1. Yanchev2 lInstitute of Experimental Morphology and Anthropology, 2Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria ( Received February 15, 1998) The probable antitumour action of ranopterinneopterin may be mediated by two mechanisms: a direct action on tumour cells by activated and NO producing cytotoxic macrophages (1,2) or indirectly by activation of host T-cell immune and defence mechanisms ( 1,3,4). The possibility that neopterin might alter tumour process was also supported by data ( 5) on elevated neopterin concentrations in body fluids during malignant disease suggesting that high neopterin levels might reflect the host's response to tumour cells or virally transformed cells. As can be concluded from in vitro data neopterin release is coupled with early events of activated cell-mediated immunity (CMI) and results support the notion that persistent preactivation of eMI without destruction of tumour cells may enhance tumour growth (3). However, in vitro tests do not necessarily reflect http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Protective Effect of Ranopterin Neopterin on Experimentally Induced Graffi Tumours in Hamsters

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References (20)

Publisher
de Gruyter
Copyright
Copyright © 1998 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pteridines.1998.9.4.196
Publisher site
See Article on Publisher Site

Abstract

Zvetkova et at.: Protective effect of ranopterin nenpterin Pteridines Vol. 9, 1998, pp. 196 - 200 Protective Effect of Ranopterin Neopterin on Experimentally Induced GrafE Tumours in Hamsters E. Zvetkova 1 §, R. Toshkova\ V. Ralchevsky\ A . Dikov\ E. Katzarova\ 1. Chowdhury! and 1. Yanchev2 lInstitute of Experimental Morphology and Anthropology, 2Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria ( Received February 15, 1998) The probable antitumour action of ranopterinneopterin may be mediated by two mechanisms: a direct action on tumour cells by activated and NO producing cytotoxic macrophages (1,2) or indirectly by activation of host T-cell immune and defence mechanisms ( 1,3,4). The possibility that neopterin might alter tumour process was also supported by data ( 5) on elevated neopterin concentrations in body fluids during malignant disease suggesting that high neopterin levels might reflect the host's response to tumour cells or virally transformed cells. As can be concluded from in vitro data neopterin release is coupled with early events of activated cell-mediated immunity (CMI) and results support the notion that persistent preactivation of eMI without destruction of tumour cells may enhance tumour growth (3). However, in vitro tests do not necessarily reflect

Journal

Pteridines – de Gruyter

Published: Nov 1, 1998

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