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Pneumothorax in Critically Ill COVID-19 Patients in the Indian Subcontinent

Pneumothorax in Critically Ill COVID-19 Patients in the Indian Subcontinent AbstractBackground and aimsTo explore the incidence and risk factors, as well as mortality, in critically ill COVID-19 patients who developed pneumothorax (PTX) and/or pneumomediastinum (PNM).MethodsA retrospective cohort study was undertaken to analyse data of all patients with moderate to severe COVID-19 disease who were either RTPCR positive or had a clinico-radiological diagnosis. The exposure group consisted of COVID-19 patients who presented with PTX/PNM, whereas the non-exposure group consisted of patients who did not develop PTX and/or PNM during the stay.ResultsIncidence of PTX/PNM was observed to be 1.9% among critically ill COVID-19 patients. 94.4% (17/18) of patients in the PTX group received positive pressure ventilation (PPV); the majority of these patients were on non-invasive ventilation when they developed PTX/PNM; only one patient was receiving conventional oxygen therapy. COVID-19 patients who developed PTX/PNM had 2.7 times higher mortality. A mortality rate of 72.2% was observed in COVID-19 patients who developed PTX/PNM.ConclusionDevelopment of PTX/PNM in critically ill COVID-19 patients is associated with more severe disease involvement, and institution of PPV is an additional risk factor. Significantly high mortality was observed following PTX/PNM in critically ill COVID-19 patients and is an independent marker of poor prognosis in COVID-19 disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Romanian Journal of Anaesthesia and Intensive Care de Gruyter

Pneumothorax in Critically Ill COVID-19 Patients in the Indian Subcontinent

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Publisher
de Gruyter
Copyright
© 2022 Anshul Singh, published by Sciendo
eISSN
2502-0307
DOI
10.2478/rjaic-2022-0002
Publisher site
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Abstract

AbstractBackground and aimsTo explore the incidence and risk factors, as well as mortality, in critically ill COVID-19 patients who developed pneumothorax (PTX) and/or pneumomediastinum (PNM).MethodsA retrospective cohort study was undertaken to analyse data of all patients with moderate to severe COVID-19 disease who were either RTPCR positive or had a clinico-radiological diagnosis. The exposure group consisted of COVID-19 patients who presented with PTX/PNM, whereas the non-exposure group consisted of patients who did not develop PTX and/or PNM during the stay.ResultsIncidence of PTX/PNM was observed to be 1.9% among critically ill COVID-19 patients. 94.4% (17/18) of patients in the PTX group received positive pressure ventilation (PPV); the majority of these patients were on non-invasive ventilation when they developed PTX/PNM; only one patient was receiving conventional oxygen therapy. COVID-19 patients who developed PTX/PNM had 2.7 times higher mortality. A mortality rate of 72.2% was observed in COVID-19 patients who developed PTX/PNM.ConclusionDevelopment of PTX/PNM in critically ill COVID-19 patients is associated with more severe disease involvement, and institution of PPV is an additional risk factor. Significantly high mortality was observed following PTX/PNM in critically ill COVID-19 patients and is an independent marker of poor prognosis in COVID-19 disease.

Journal

Romanian Journal of Anaesthesia and Intensive Care – de Gruyter

Published: Jul 1, 2022

Keywords: COVID-19; acute respiratory distress syndrome; pneumothorax; pneumomediastinum; positive pressure ventilation

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