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Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep vein thrombosis

Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep... Abstract We studied total plasma homocysteine levels (tHcy) in Algerian patients with a deep venous thrombosis (DVT). We measured tHcy levels in a total of 99 subjects enrolled in this study, including 40 patients with DVT and 59 healthy controls. The mean tHcy level in the patients was 12.62±8.7 μmol/L and that in the controls was 10.2± 2.1 μmol/L. In a univariate regression model, tHcy concentrations were inversely correlated with triglycerides (TG) ( r =–0.358; p=0.023) and total cholesterol (TC) ( r =–0.454; p=0.003) concentrations. Logistic regression analysis showed that tHcy after adjustment was significantly associated with the following factors: TC (p=0.003) and TG (p=0.023). The analysis in DVT patients showed that variables independently associated with tHcy were TC (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.7–2.6), low-density lipoprotein cholesterol (OR 2.0, 95% CI 1.6–2.5), creatinine (OR 2.2, 95% CI 1.7–2.6), and smoking (OR 2.1, 95% CI 1.7–2.5). In conclusion, these results indicate that tHcy levels and other biochemical parameters are important determinant factors for DVT diseases in Algerian patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep vein thrombosis

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References (64)

Publisher
de Gruyter
Copyright
Copyright © 2014 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pterid-2014-0009
Publisher site
See Article on Publisher Site

Abstract

Abstract We studied total plasma homocysteine levels (tHcy) in Algerian patients with a deep venous thrombosis (DVT). We measured tHcy levels in a total of 99 subjects enrolled in this study, including 40 patients with DVT and 59 healthy controls. The mean tHcy level in the patients was 12.62±8.7 μmol/L and that in the controls was 10.2± 2.1 μmol/L. In a univariate regression model, tHcy concentrations were inversely correlated with triglycerides (TG) ( r =–0.358; p=0.023) and total cholesterol (TC) ( r =–0.454; p=0.003) concentrations. Logistic regression analysis showed that tHcy after adjustment was significantly associated with the following factors: TC (p=0.003) and TG (p=0.023). The analysis in DVT patients showed that variables independently associated with tHcy were TC (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.7–2.6), low-density lipoprotein cholesterol (OR 2.0, 95% CI 1.6–2.5), creatinine (OR 2.2, 95% CI 1.7–2.6), and smoking (OR 2.1, 95% CI 1.7–2.5). In conclusion, these results indicate that tHcy levels and other biochemical parameters are important determinant factors for DVT diseases in Algerian patients.

Journal

Pteridinesde Gruyter

Published: Dec 1, 2014

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