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- Publisher
- de Gruyter
- Copyright
- Copyright © 2015 by the
- ISSN
- 2193-0635
- eISSN
- 2193-0643
- DOI
- 10.1515/plm-2014-0052
- Publisher site
- See Article on Publisher Site
Abstract
Photon Lasers Med 2015; 4(1): 13 Editorial Photodynamische Diagnostik und Therapie Was verspricht die Zukunft? DOI 10.1515/plm-2014-0052 This special issue is dedicated to photodynamics, the diagnostic and therapeutic use of photosensitizers activated by light. Although the roots go back to the late 19th century [1], in many clinical disciplines photodynamics is still not as well established as researchers would have expected or hoped. In this editorial, we want to shed some light on why this is and whether photodynamic procedures have a more promising future. Photodynamic diagnosis (PDD) involves exciting and detecting tissue fluorescence from a previously administered photosensitizing drug and drawing diagnostic conclusions from the signals obtained. It is part of a broader range of photodiagnostic techniques (PD), which include autofluorescence, non-phototoxic drug fluorescence (e.g., labeled antibodies) and other ways of interrogating tissue with optical signals and analyzing the emitted signal, such as elastic scattering spectroscopy. PDD overlaps with photodynamic therapy (PDT) in which tissue ablation can be achieved by activating photosensitizers with light, leading to necrosis or apoptosis. The term "photodynamic therapy" dates back to 1904, when Prof. Hermann von Tappeiner was trying to clarify how the mechanism behind the phototoxicity, which he and his
Journal
Photonics & Lasers in Medicine – de Gruyter
Published: Feb 1, 2015