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Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning Abstract 3D tubular scaffolds made from Poly-(Ɛ-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS solutions is studied. The influence of different CS solutions (CS/polyethylene glycol (PEO)/glacial acetic acid (AcOH), CS/trifluoroacetic acid (TFA), CS/ AcOH) on fibre formation and producibility of nanofibrous tubes is investigated. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) is used to verify the presence of CS in the blended samples. Tensile testing and pore size measurements are done to underline the good prerequisites of the fabricated blended PCL/ CS nanofibrous tubes as potential scaffolds for vascular grafts. Tubes fabricated from the combination of PCL and CS dissolved in AcOH possesses properties, which are favourable for future cell culture studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autex Research Journal de Gruyter

Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

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Publisher
de Gruyter
Copyright
Copyright © 2015 by the
ISSN
2300-0929
eISSN
2300-0929
DOI
10.1515/aut-2015-0016
Publisher site
See Article on Publisher Site

Abstract

Abstract 3D tubular scaffolds made from Poly-(Ɛ-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS solutions is studied. The influence of different CS solutions (CS/polyethylene glycol (PEO)/glacial acetic acid (AcOH), CS/trifluoroacetic acid (TFA), CS/ AcOH) on fibre formation and producibility of nanofibrous tubes is investigated. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) is used to verify the presence of CS in the blended samples. Tensile testing and pore size measurements are done to underline the good prerequisites of the fabricated blended PCL/ CS nanofibrous tubes as potential scaffolds for vascular grafts. Tubes fabricated from the combination of PCL and CS dissolved in AcOH possesses properties, which are favourable for future cell culture studies.

Journal

Autex Research Journalde Gruyter

Published: Mar 1, 2015

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