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- Publisher
- de Gruyter
- Copyright
- © 2019 Polish Society of Hematology and Transfusion Medicine, Insitute of Hematology and Transfusion Medicine. Published by Sciendo
- eISSN
- 2300-7117
- DOI
- 10.2478/ahp-2019-0002
- Publisher site
- See Article on Publisher Site
Abstract
StreszczenieTransplantacja komórek krwiotwórczych (hematopoietic cell transplantation – HCT ) jest ugruntowaną metodą leczenia zarówno nienowotworowych, jak i rozrostowych chorób układu krwiotwórczego. U kobiet wiąże się jednak z występowaniem powikłań wczesnych i późnych dotyczących układu moczowo-płciowego. Konsekwencją gonadotoksycznego postępowania przygotowawczego (chemioterapii i radioterapii) jest przedwczesne wygaśnięcie funkcji jajników. U biorczyń allogenicznych przeszczepów (allogeneic HCT, allo-HCT) dodatkowo występują powikłania związane z występowaniem przewlekłej choroby przeczep przeciw gospodarzowi (chronic graft-versus-host disease – cGvHD) w istotny sposób upośledzające jakość życia kobiet w przypadku zajęcia strefy anogenitalnej (GvHDgyn). Dodatkowo przewlekła immunosupresja sprzyja występowaniu wtórnych nowotworów układu moczowo-płciowego. Pacjentki po HCT, szczególnie obciążone cGvHD, wymagają długoletniej interdyscyplinarnej opieki, włączając opiekę ginekologiczną. W pracy przedstawiono problemy ginekologiczne pacjentek po HCT oraz zaproponowano schemat standardu opieki ginekologicznej po transplantacji na podstawie piśmiennictwa i własnych doświadczeń.
Journal
Acta Haematologica Polonica – de Gruyter
Published: May 8, 2019