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One-pot Synthesis of 3-Aryl-substituted 1-Hydroxy-2-acylindolizines

One-pot Synthesis of 3-Aryl-substituted 1-Hydroxy-2-acylindolizines A new method for the formation of C-C bonds in a one-pot synthesis of 1-hydroxy-2-acyl-3- arylindolizines (acyl: 2-pyridylformyl, thienylformyl; aryl: phenyl, pyridyl, thienyl) from the reaction of 1,3-diketones with aldehydes has been evaluated. X-Ray diffraction studies of single crystals have provided structural information about the so-formed indolizines. In the crystalline state, the hydroxyl units form intra- or intermolecular hydrogen bonds to the acyl functionalities. The color of these indolizines depends on the pH value of the solvent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Naturforschung B de Gruyter

One-pot Synthesis of 3-Aryl-substituted 1-Hydroxy-2-acylindolizines

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References (5)

Publisher
de Gruyter
Copyright
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
ISSN
0932-0776
eISSN
1865-7117
DOI
10.5560/znb.2012-0230
Publisher site
See Article on Publisher Site

Abstract

A new method for the formation of C-C bonds in a one-pot synthesis of 1-hydroxy-2-acyl-3- arylindolizines (acyl: 2-pyridylformyl, thienylformyl; aryl: phenyl, pyridyl, thienyl) from the reaction of 1,3-diketones with aldehydes has been evaluated. X-Ray diffraction studies of single crystals have provided structural information about the so-formed indolizines. In the crystalline state, the hydroxyl units form intra- or intermolecular hydrogen bonds to the acyl functionalities. The color of these indolizines depends on the pH value of the solvent.

Journal

Zeitschrift für Naturforschung B – de Gruyter

Published: Nov 1, 2012

Keywords: Aza-Nazarov Cyclization; Fused-ring Systems; Indolizines; Multi-component Reaction; Nitrogen Heterocycles

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