Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Summary Serum kynurenine and neopterin concentrations were determined in patients with chronic mesangioproliferative glomerulonephritis with normal renal function and in patients with chronic renal failure. Significantly increased kynurenine and neopterin levels have been observed in 28% of mesangioproliferative glomerulonephritis patients. In vitro, interferon-y induces the formation of neopterin in human monocytes/macrophages. Also the degradation of tryptophan via the kynurenine pathway is induced by interferon-yo Our data show increased kynurenine and neopterin concentrations in serum in the case of mesangioproliferative glomerulonephritis. There was a positive correlation between serum kynurenine and neopterin levels. The same association between kynurenine and neopterin have been found in patients with chronic renal failure . At the end stage of renal disease, elevated levels of kynurenine and neopterin corresponded to the decrease of renal functions. In 59% of patients with mesangioproliferative glomerulonephritis, we detected also pyridoxal-5-phosphate deficiency concomitant with the increase of serum concentration of kynurenine. L-tryptophan peroral loading test could be useful for differentiation the both causes of hyperkynureninemia.
Pteridines – de Gruyter
Published: Nov 1, 1998
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.