Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School

Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R.... Abstract The research interests of the Hamblin Laboratory are broadly centered on the use of different kinds of light to treat many different diseases. Photodynamic therapy (PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria, cancer cells and destroy unwanted tissue. Likewise, UV light is also good at killing especially pathogens. By contrast, red or near-infrared light can have the opposite effect, to act to preserve tissue from dying and can stimulate healing and regeneration. In all these applications, nanotechnology is having an ever-growing impact. In PDT, self-assembled nano-drug carriers (micelles, liposomes, etc.) play a great role in solubilizing the photosensitizers, metal nanoparticles can carry out plasmon resonance enhancement, and fullerenes can act as photosensitizers, themselves. In the realm of healing, single-walled carbon nanotubes can be electrofocused to produce nano-electonic biomedical devices, and nanomaterials will play a great role in restorative dentistry. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nanotechnology Reviews de Gruyter

Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School

Download PDF
14 pages

Loading next page...
 
/lp/de-gruyter/nanotechnology-for-photodynamic-therapy-a-perspective-from-the-0FHgbi0FqO

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
de Gruyter
Copyright
Copyright © 2015 by the
ISSN
2191-9089
eISSN
2191-9097
DOI
10.1515/ntrev-2015-0027
Publisher site
See Article on Publisher Site

Abstract

Abstract The research interests of the Hamblin Laboratory are broadly centered on the use of different kinds of light to treat many different diseases. Photodynamic therapy (PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria, cancer cells and destroy unwanted tissue. Likewise, UV light is also good at killing especially pathogens. By contrast, red or near-infrared light can have the opposite effect, to act to preserve tissue from dying and can stimulate healing and regeneration. In all these applications, nanotechnology is having an ever-growing impact. In PDT, self-assembled nano-drug carriers (micelles, liposomes, etc.) play a great role in solubilizing the photosensitizers, metal nanoparticles can carry out plasmon resonance enhancement, and fullerenes can act as photosensitizers, themselves. In the realm of healing, single-walled carbon nanotubes can be electrofocused to produce nano-electonic biomedical devices, and nanomaterials will play a great role in restorative dentistry.

Journal

Nanotechnology Reviews – de Gruyter

Published: Aug 1, 2015

References

  • Carbon nanotubes part II : a remarkable carrier for drug and gene delivery
    Karimi
  • future in dentistry Saudi
    Shetty
  • photodynamic inactivation and photodynamic therapy for infections
    Huang
  • Stable synthetic bacteriochlorins for photodynamic therapy : role of dicyano peripheral groups central metal substitution delivery
    Huang
  • Interest of RGD - containing linear or cyclic peptide targeted tetraphenylchlorin as novel photosensitizers for selective photodynamic activity
    Frochot
  • MR Photosensitizer targeting in photodynamic therapy II Conjugates of haematoporphyrin with serum lipoproteins
    Hamblin
  • Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates
    Molpus
  • combining nanostructured materials and stem cells for dental tissue regeneration
    Mitsiadis TA
  • its application in dentistry
    Abiodun
  • The embedding of meta - tetra hydroxyphenyl chlorin into silica nanoparticle platforms for photodynamic therapy and their singlet oxygen production and pH - dependent optical properties
    Yan
  • Toxicological properties of nanomaterials
    Zhang
  • IG MR Part the synthesis of some heterocyclic spirodienones by phenolic coupling
    Coutts
  • Fabrication of channel waveguides from sol - gel - processed polyvinylpyrrolidone SiO composite materials
    Yoshida
  • DA pharmacokinetics and antitumor efficacy of the photodynamic sensitizer hexyloxyethyl devinyl pyropheophorbide - a
    Bellnier
  • characterization and in vitro application of methylene blue - containing nanoparticle platforms
    Tang
  • MR targeted photodynamic therapy : scavenger receptor expression and activation state
    Liu
  • of next - generation macromolecular drugs based on the EPR effect challenges and pitfalls
    Nakamura
  • Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma
    Mroz
  • Gad Targeted photodynamic therapy of established soft - tissue infections in mice
    Zahra
  • Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer
    Ohulchanskyy
  • NS MR SS Targeted antimicrobial photochemotherapy Agents Chemother
    Soukos
  • Inactivation of Microbial Pathogens Medical and Environmental Applications Publishing
    Hamblin
  • Cationic fullerenes are effective and selective antimicrobial photosensitizers
    Tegos
  • LK colloid formation in aqueous systems : effects of preparation method on size structure and surface charge
    Duncan
  • Stable synthetic bacteriochlorins for photodynamic therapy : role of dicyano peripheral groups central metal substitution delivery
    Huang
  • EM Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water
    Hotze
  • Pegylation of charged polymer - photosensitiser conjugates : effects on photodynamic efficacy
    Hamblin
  • EM Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water
    Hotze
  • MR targeted photodynamic therapy
    Demidova
  • MR Photosensitizer targeting in photodynamic therapy Conjugates of haematoporphyrin with albumin and transferrin
    Hamblin
  • CM a review of its use in the management of subfoveal choroidal neovascularisation
    Fenton
  • DA photosensitizer conjugates : effects of chain length and Gram classification on the photodynamic inactivation of bacteria
    Hamblin
  • Asynchronous magnetic bead rotation microviscometer for label - free DNA analysis
    Li
  • In vivo fluorescence imaging of the transport of charged chlorin conjugates in a rat orthotopic prostate tumour
    Hamblin
  • Pegylation of a chlorin polymer conjugate increases tumor targeting of photosensitizer
    Hamblin
  • therapy of cancer an update CA
    Agostinis
  • nanochemistry controlling the excitation dynamics for frequency up - and down - conversion in lanthanide - doped nanoparticles
    Chen
  • AN Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycle
    Pliss
  • combining nanostructured materials and stem cells for dental tissue regeneration
    Mitsiadis TA
  • Evaluation of bacteriochlorophyll - reconstituted low - density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo
    Marotta
  • Gold nanoshells - mediated bimodal photodynamic and photothermal cancer treatment using ultra - low doses of near infra - red light
    Vankayala
  • part preparation of a novel and versatile drug - delivery vehicle
    Karimi
  • Gold nanoshells - mediated bimodal photodynamic and photothermal cancer treatment using ultra - low doses of near infra - red light
    Vankayala
  • nanochemistry controlling the excitation dynamics for frequency up - and down - conversion in lanthanide - doped nanoparticles
    Chen
  • IG MR The enzymatic oxidation of phenolic tetrahydroisoquinoline carboxylic acids
    Coutts
  • Photodynamic therapy for methicillin - resistantStaphylococcus aureusinfection in a mouse skin abrasion model Lasers
    Dai
  • Antimicrobial photodynamic inactivation with decacationic functionalized fullerenes : oxygen independent photokilling in presence of azide and new mechanistic insights Free
    Yin
  • Photodynamic therapy forAcinetobacter baumanniiburn infections in mice Agents
    Dai
  • Effect of charge on the interaction of site - specific photoimmunoconjugates with human ovarian cancer cells
    Hamblin
  • LK colloid formation in aqueous systems : effects of preparation method on size structure and surface charge
    Duncan
  • Interest of RGD - containing linear or cyclic peptide targeted tetraphenylchlorin as novel photosensitizers for selective photodynamic activity
    Frochot
  • Gad Targeted photodynamic therapy of established soft - tissue infections in mice
    Zahra
  • Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer
    Ohulchanskyy
  • MR therapy a new antimicrobial approach to infectious disease
    Hamblin
  • Pegylation of charged polymer - photosensitiser conjugates : effects on photodynamic efficacy
    Hamblin
  • Cationic fullerenes are effective and selective antimicrobial photosensitizers
    Tegos
  • Gold mining for great expectations from tiny nanoparticles Photodyn
    Gamaleia
  • MR Photodynamic therapy with fullerenes in vivo : reality or a dream
    Sharma
  • MR targeted photodynamic therapy : scavenger receptor expression and activation state
    Liu
  • IG MR Synthesis of spiroheterocycles by oxidative coupling of phenolic sulphonamides
    Coutts
  • MR CH AT Optical monitoring and treatment of potentially lethal wound infections in vivo
    Hamblin
  • Fabrication of channel waveguides from sol - gel - processed polyvinylpyrrolidone SiO composite materials
    Yoshida
  • Two - photon photodynamic therapy Laser
    Bhawalkar
  • Del Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a chlorin immunoconjugate
    Governatore
  • Antimicrobial photodynamic inactivation with decacationic functionalized fullerenes : oxygen independent photokilling in presence of azide and new mechanistic insights Free
    Yin
  • Del Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a chlorin immunoconjugate
    Governatore
  • Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle
    Garcia
  • synthesis and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy
    Schneider
  • rd Ultrafast dynamics in multibranched structures with enhanced two - photon absorption
    Wang
  • Photodynamic therapy for methicillin - resistantStaphylococcus aureusinfection in a mouse skin abrasion model Lasers
    Dai
  • AS de PA Liposomes for photodynamic therapy
    Derycke
  • Evaluation of bacteriochlorophyll - reconstituted low - density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo
    Marotta
  • light source smaller than the optical wavelength
    Lieberman
  • AN Characterization of porphyrins chlorins and bacteriochlorins formed via allomerization of bacteriochlorophyll a Synthesis of highly stable bacteriopurpurinimides and their metal complexes
    Kozyrev
  • MR On the mechanism of the tumour - localising effect in photodynamic therapy
    Hamblin
  • MR Antimicrobial photodynamic therapy and photodynamic inactivation or killing bugs with dyes and light a symposium - in - print
    Hamblin
  • Inhibition of aggregation of bacteriochlorophyllides in mesoporous silica
    Dandler
  • MR Photosensitizer targeting in photodynamic therapy Conjugates of haematoporphyrin with albumin and transferrin
    Hamblin
  • Optical nanosensors for chemical analysis inside single living cells for pH and calcium and the intracellular application of PEBBLE sensors
    Clark HA
  • Personalized neuroprosthetics rv
    Borton
  • Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates
    Molpus
  • MR DA CH Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Hamblin
  • MR targeted photodynamic therapy
    Demidova
  • light source smaller than the optical wavelength
    Lieberman
  • AN Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycle
    Pliss
  • Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor
    Tawakol
  • Photosensitizer delivery to vulnerable atherosclerotic plaque : comparison of macrophage - targeted conjugate versus free chlorine
    Tawakol
  • In vivo fluorescence imaging of the transport of charged chlorin conjugates in a rat orthotopic prostate tumour
    Hamblin
  • therapy in dentistry a literature
    Gursoy
  • IG MR Synthesis of spiroheterocycles by oxidative coupling of phenolic sulphonamides
    Coutts
  • NS MR The effect of charge on cellular uptake and phototoxicity of polylysine chlorin conjugates
    Soukos
  • The biosynthesis of showdomycin studies with stable isotopes and the determination of principal precursors
    Buchanan
  • Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor
    Tawakol
  • Synthesis photophysical and electrochemistry of near - IR absorbing bacteriochlorins related to bacteriochlorophyll a
    Kozyrev
  • Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma
    Mroz
  • Photodynamic therapy forStaphylococcus aureusinfected burn wounds in mice
    Lambrechts
  • therapy of cancer an update CA
    Agostinis
  • The embedding of meta - tetra hydroxyphenyl chlorin into silica nanoparticle platforms for photodynamic therapy and their singlet oxygen production and pH - dependent optical properties
    Yan
  • Effect of charge on the interaction of site - specific photoimmunoconjugates with human ovarian cancer cells
    Hamblin
  • of next - generation macromolecular drugs based on the EPR effect challenges and pitfalls
    Nakamura
  • photodynamic inactivation and photodynamic therapy for infections
    Huang
  • Photodynamic therapy forStaphylococcus aureusinfected burn wounds in mice
    Lambrechts
  • - targeted mesoporous silica nanoparticles for photodynamic therapy
    Brevet
  • Scavenger - receptor targeted photodynamic therapy
    Hamblin
  • LK based restorative materials for dental caries management
    Melo MA
  • AS de PA Liposomes for photodynamic therapy
    Derycke
  • therapy in dentistry a literature
    Gursoy
  • IG MR The enzymatic oxidation of phenolic tetrahydroisoquinoline carboxylic acids
    Coutts
  • Inactivation of Microbial Pathogens Medical and Environmental Applications Publishing
    Hamblin
  • reactions on photoprotoporphyrin IX : new synthetic models for the special pair of the photosynthetic reaction center
    Zheng
  • KM Nanosized voltmeter enables cellular - wide electric field mapping
    Tyner
  • MR therapy a new antimicrobial approach to infectious disease
    Hamblin
  • wide open playing field for chemists
    Culotta
  • Functionalized fullerenes mediate photodynamic killing of cancer cells type versus type II photochemical mechanism Free
    Mroz
  • Electrofocusing for Bio Devices Publishing Philadelphia
    Lakshmanan
  • future in dentistry Saudi
    Shetty
  • MR Photodynamic therapy with fullerenes in vivo : reality or a dream
    Sharma
  • Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle
    Garcia
  • DA pharmacokinetics and antitumor efficacy of the photodynamic sensitizer hexyloxyethyl devinyl pyropheophorbide - a
    Bellnier
  • KM Nanosized voltmeter enables cellular - wide electric field mapping
    Tyner
  • Pegylation of a chlorin polymer conjugate increases tumor targeting of photosensitizer
    Hamblin
  • MR Photosensitizer targeting in photodynamic therapy II Conjugates of haematoporphyrin with serum lipoproteins
    Hamblin
  • rd Ultrafast dynamics in multibranched structures with enhanced two - photon absorption
    Wang
  • LK based restorative materials for dental caries management
    Melo MA
  • Da Photodynamic therapy targeting neuropilin interest of pseudopeptides with improved stability properties
    Thomas
  • Targeting - triggered porphysome nanostructure disruption for activatable photodynamic therapy
    Jin
  • The biosynthesis of showdomycin studies with stable isotopes and the determination of principal precursors
    Buchanan
  • MR CH AT Optical monitoring and treatment of potentially lethal wound infections in vivo
    Hamblin
  • Optical nanosensors for chemical analysis inside single living cells for pH and calcium and the intracellular application of PEBBLE sensors
    Clark HA
  • Biosynthesis of aromatic isoprenoids part the preparation of dimethylallyl tryptophan and cyclo alanyl tryptophan and their non - incorporation into echinulin
    Grundon
  • MR DA CH Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Hamblin
  • The novel albumin - chitosan core - shell nanoparticles for gene delivery preparation optimization and cell uptake investigation
    Karimi
  • Gad Effects of growth phase and extracellular slime on photodynamic inactivation of gram - positive pathogenic bacteria Antimicrob Agents Chemother
    Zahra
  • MR On the mechanism of the tumour - localising effect in photodynamic therapy
    Hamblin
  • synthesis and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy
    Schneider
  • The biosynthesis of pyrazofurin and formycin
    Buchanan
  • The biosynthesis of pyrazofurin and formycin
    Buchanan
  • IG MR Part the synthesis of some heterocyclic spirodienones by phenolic coupling
    Coutts
  • Personalized neuroprosthetics rv
    Borton
  • Asynchronous magnetic bead rotation microviscometer for label - free DNA analysis
    Li
  • The novel albumin - chitosan core - shell nanoparticles for gene delivery preparation optimization and cell uptake investigation
    Karimi
  • - targeted mesoporous silica nanoparticles for photodynamic therapy
    Brevet
  • Da Photodynamic therapy targeting neuropilin interest of pseudopeptides with improved stability properties
    Thomas
  • Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections
    Lu
  • Toxicological properties of nanomaterials
    Zhang
  • Two - photon photodynamic therapy Laser
    Bhawalkar
  • Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections
    Lu
  • NS MR SS Targeted antimicrobial photochemotherapy Agents Chemother
    Soukos
  • Observation of stimulated emission by direct three - photon excitation
    He
  • reactions on photoprotoporphyrin IX : new synthetic models for the special pair of the photosynthetic reaction center
    Zheng
  • DA photosensitizer conjugates : effects of chain length and Gram classification on the photodynamic inactivation of bacteria
    Hamblin
  • its application in dentistry
    Abiodun
  • Synthesis photophysical and electrochemistry of near - IR absorbing bacteriochlorins related to bacteriochlorophyll a
    Kozyrev
  • Photodynamic therapy forAcinetobacter baumanniiburn infections in mice Agents
    Dai
  • characterization and in vitro application of methylene blue - containing nanoparticle platforms
    Tang
  • CM a review of its use in the management of subfoveal choroidal neovascularisation
    Fenton
  • Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy
    Wang
  • Carbon nanotubes part II : a remarkable carrier for drug and gene delivery
    Karimi
  • Electrofocusing for Bio Devices Publishing Philadelphia
    Lakshmanan
  • NS MR The effect of charge on cellular uptake and phototoxicity of polylysine chlorin conjugates
    Soukos
  • Gold mining for great expectations from tiny nanoparticles Photodyn
    Gamaleia
  • AN Characterization of porphyrins chlorins and bacteriochlorins formed via allomerization of bacteriochlorophyll a Synthesis of highly stable bacteriopurpurinimides and their metal complexes
    Kozyrev
  • Functionalized fullerenes mediate photodynamic killing of cancer cells type versus type II photochemical mechanism Free
    Mroz
  • Scavenger - receptor targeted photodynamic therapy
    Hamblin
  • Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria
    Demidova
  • Inhibition of aggregation of bacteriochlorophyllides in mesoporous silica
    Dandler
  • Biosynthesis of aromatic isoprenoids part the preparation of dimethylallyl tryptophan and cyclo alanyl tryptophan and their non - incorporation into echinulin
    Grundon
  • Observation of stimulated emission by direct three - photon excitation
    He
  • wide open playing field for chemists
    Culotta
  • Targeting - triggered porphysome nanostructure disruption for activatable photodynamic therapy
    Jin
  • part preparation of a novel and versatile drug - delivery vehicle
    Karimi
  • Photosensitizer delivery to vulnerable atherosclerotic plaque : comparison of macrophage - targeted conjugate versus free chlorine
    Tawakol
  • Gad Effects of growth phase and extracellular slime on photodynamic inactivation of gram - positive pathogenic bacteria Antimicrob Agents Chemother
    Zahra
  • Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy
    Wang
  • Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria
    Demidova
  • MR Antimicrobial photodynamic therapy and photodynamic inactivation or killing bugs with dyes and light a symposium - in - print
    Hamblin