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- Publisher
- de Gruyter
- Copyright
- © 2017 Walter de Gruyter GmbH, Berlin/Boston
- eISSN
- 2544-0349
- DOI
- 10.1515/ii-2017-0164
- Publisher site
- See Article on Publisher Site
Abstract
AbstractNADPH oxidase is the main source of intracellular reactive oxygen species (ROS). ROS plays an important role in a variety of tumor types. The ROS mediated by NADPH oxidase increases the expression of hypoxia-inducible factor alpha (HIF-α) through multiple signaling pathways in tumor, and HIF-α could be regulated and controlled by downstream multiple targeted genes such as vascular endothelial growth factor, glucose transporter to promote tumor angiogenesis, cell energy metabolism reprogram and tumor metastasis. Meanwhile, HIF-α can also regulate the expression of NADPH oxidase by ROS, thus further promoting development of tumor. In this review, we summarized the functions of NADPH in tumorigenesis and discussed their potential implications in cancer therapy.
Journal
Infection International – de Gruyter
Published: Apr 10, 2018