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J. Witte, B. Schoenmaekers, D. Sessler, T. Deloof (2001)
The Analgesic Efficacy of Tramadol is Impaired by Concurrent Administration of OndansetronAnesthesia & Analgesia, 92
G. Mion, T. Villevieille (2013)
Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)CNS Neuroscience & Therapeutics, 19
H. Unlugenc, Sibel Tetiker, S. Büyükkurt, T. Guler, G. Işık (2018)
Comparison of the effect of adding remifentanil to patient-controlled tramadol or morphine for postoperative analgesia after major abdominal surgery.Journal of opioid management, 5 5
Marko Peltoniemi, N. Hagelberg, K. Olkkola, T. Saari (2016)
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain TherapyClinical Pharmacokinetics, 55
K. Minami, Yuka Sudo, K. Miyano, Robert Murphy, Y. Uezono (2015)
µ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1)Journal of Anesthesia, 29
Ketamine versus tramadol as an adjunct to morphine for analgesia after major abdominal surgery morphine : effect of adding ketamine
M. Carstensen, Moller Am (2010)
Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.British journal of anaesthesia, 104 4
Le Shen, Yuguang Huang (2016)
Role of Postoperative Multimodal Analgesia in Abdominal and Pelvic Enhanced Recovery after Surgery.Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 38 4
M. Reeves, D. Lindholm, P. Myles, H. Fletcher, J. Hunt (2001)
Adding Ketamine to Morphine for Patient-Controlled Analgesia After Major Abdominal Surgery: A Double-Blinded, Randomized Controlled TrialAnesthesia & Analgesia, 93
Jamie Murphy, Dawn Yan, Marie Hanna, E. Bravos, G. Isaac, Calvin Eng, Christopher Wu (2010)
Comparison of the postoperative analgesic efficacy of intravenous patient-controlled analgesia with tramadol to intravenous patient-controlled analgesia with opioids.Journal of opioid management, 6 2
Kelly Elterman, Zhilin Xiong (2015)
Coagulation profile changes and safety of epidural analgesia after hepatectomy: a retrospective studyJournal of Anesthesia, 29
S. Kocabaş, S. Karaman, E. Uysallar, V. Fırat (2005)
The use of tramadol and morphine for pain relief after abdominal hysterectomy.Clinical and experimental obstetrics & gynecology, 32 1
J. Eng
Sample Size Estimation : How Many Individuals Should Be Studied ?
S. Ide, M. Minami, K. Ishihara, G. Uhl, I. Sora, K. Ikeda (2006)
Mu opioid receptor-dependent and independent components in effects of tramadolNeuropharmacology, 51
A. Webb, S. Leong, P. Myles, Sara Burn (2002)
The Addition of a Tramadol Infusion to Morphine Patient-Controlled Analgesia After Abdominal Surgery: A Double-Blinded, Placebo-Controlled Randomized TrialAnesthesia & Analgesia, 95
G. Adriaenssens, K. Vermeyen, V. Hoffmann, E. Mertens, H. Adriaensen (1999)
Postoperative analgesia with i.v. patient-controlled morphine: effect of adding ketamine.British journal of anaesthesia, 83 3
H. Unlugenc, M. Gündüz, M. Ozalevli, H. Akman (2002)
A comparative study on the analgesic effect of tramadol, tramadol plus magnesium, and tramadol plus ketamine for postoperative pain management after major abdominal surgeryActa Anaesthesiologica Scandinavica, 46
(2011)
Ketamine in pain managementAdv Psychosom Med, 30
A. Page, B. Rostad, C. Staley, J. Levy, Jaemin Park, M. Goodman, J. Sarmiento, J. Galloway, K. Delman, D. Kooby (2008)
Epidural analgesia in hepatic resection.Journal of the American College of Surgeons, 206 6
Fuzhou Wang, X. Shen, Shiqin Xu, Yusheng Liu (2009)
Preoperative tramadol combined with postoperative small-dose tramadol infusion after total abdominal hysterectomy: a double-blind, randomized, controlled trialPharmacological Reports, 61
D. Pacheco, T. Romero, I. Duarte (2014)
Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptorsBrain Research, 1562
X. Shen, Fuzhou Wang, Shiqin Xu, Li Ma, Yusheng Liu, S. Feng, Wangeng Wang, Qingsong Zhao, Xiaohong Li, Liping Zhao, Xianqiang Yao, J. Qu, B. Xie, Huiping Wang, Hongmei Yuan, Y. Cao, Yan-yuan Sun, Wei Wang, Limei Guo, Zisong Song, Zhi Wang, Xueneng Guan (2008)
Comparison of the analgesic efficacy of preemptive and preventive tramadol after lumpectomy.Pharmacological reports : PR, 60 3
N. Guillou, M. Tanguy, P. Seguin, B. Branger, J. Campion, Y. Mallédant (2003)
The Effects of Small-Dose Ketamine on Morphine Consumption in Surgical Intensive Care Unit Patients After Major Abdominal SurgeryAnesthesia & Analgesia, 97
R. Arcioni, M. Rocca, S. Romanò, R. Romano, P. Pietropaoli, A. Gasparetto (2002)
Ondansetron Inhibits the Analgesic Effects of Tramadol: A Possible 5-HT3 Spinal Receptor Involvement in Acute Pain in HumansAnesthesia & Analgesia, 94
P. Tilleul, M. Aissou, F. Bocquet, N. Thiriat, O. Grelle, M. Burke, J. Hutton, M. Beaussier (2012)
Cost-effectiveness analysis comparing epidural, patient-controlled intravenous morphine, and continuous wound infiltration for postoperative pain management after open abdominal surgery.British journal of anaesthesia, 108 6
C. Stiller, H. Lundblad, L. Weidenhielm, T. Tullberg, B. Grantinger, P. Lafolie, K. Jansson (2007)
The addition of tramadol to morphine via patient‐controlled analgesia does not lead to better post‐operative pain relief after total knee arthroplastyActa Anaesthesiologica Scandinavica, 51
A. Lepri, S. Sia, S. Catinelli, R. Casali, G. Novelli (2006)
Patient-controlled analgesia with tramadol versus tramadol plus ketorolac.Minerva anestesiologica, 72 1-2
J. Persson (2013)
Ketamine in Pain ManagementCNS Neuroscience & Therapeutics, 19
Test employed: Fisher's exact test. Key: PONV, postoperative nausea and vomiting
C. Murdoch, B. Crooks, C. Miller (2002)
Effect of the addition of ketamine to morphine in patient‐controlled analgesiaAnaesthesia, 57
AbstractBackground and aimsPatient-controlled analgesia (PCA) with morphine is commonly used to provide analgesia following major surgery, but is not sufficient as a monotherapy strategy. This study aimed to compare the adjunctive analgesic effect of ketamine versus tramadol on postoperative analgesia provided via PCA-morphine in patients undergoing major upper abdominal surgeries.MethodsForty-two patients undergoing elective major upper abdominal surgery under general anesthesia were allocated to receive either ketamine (load dose of 0.5 mg kg−1 followed by a continuous infusion of 0.12 mg kg−1 h−1 up to 48 postoperative hours; ketamine group, n = 21) or tramadol (load dose of 1 mg kg−1 followed by a continuous infusion of 0.2 mg kg−1 h−1 up to 48 postoperative hours; tramadol group, n = 21) in addition to their standard postoperative analgesia with PCA-morphine. Postoperative data included morphine consumption, visual analog scale (VAS) scores, and side effects during the first 48 postoperative hours after PCA-morphine initiation.ResultsThere were no significant differences in patient demographic and intraoperative data between the two groups. Tramadol group had significantly less total morphine consumption during the first 48 postoperative hours (28.905 [16.504] vs 54.524 [20.846] mg [p < 0.001]) and presented significantly lower VAS scores at rest and mobilization (p < 0.05) than the ketamine group. No statistical difference was recorded between the two groups (p > 0.05) regarding postoperative cough, sedation, hallucinations, pruritus, urine retention, and postoperative nausea and vomiting. However, patients in the ketamine group reported dry mouth more frequently than patients in the tramadol group (p = 0.032).ConclusionsPostoperative administration of tramadol was superior to ketamine due to significantly reduced opioid consumption and better pain scores in patients receiving PCA-morphine after major upper abdominal surgery.
Romanian Journal of Anaesthesia and Intensive Care – de Gruyter
Published: Jul 1, 2020
Keywords: Ketamine; tramadol; morphine; postoperative analgesia
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