Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Is folic acid supplementation to food benefit or risk for human health?

Is folic acid supplementation to food benefit or risk for human health? AbstractThe need for sufficient quantities of folic acid for normal embryogenesis and fetal development is well known. Women of childbearing age must be sure to have an adequate intake of folic acid periconceptionally prior to and during pregnancy. Folate plays an essential role in the biosynthesis of RNA and DNA, phospholipid and neurostransmitters synthesis, using S-adenosylmethionine (SAM) as the primary methyl group donor. In some countries, the knowledge that folic acid is preventable for the reduction of the risk for neural tube defects (NTD) and in lowering the high amount of homocysteine (Hcy) led to the recommendation that all women capable of becoming pregnant should consume 400 µg of folic acid daily. Later, in 1998, folic acid fortification of all enriched cereal grain product flour was implemented in some countries. In addition to careful monitoring of adverse effects, the studies are warranted in order to determine the potentially positive and deleterious effects of folic acid fortification and supplementation on the human health or human diseases. To further understand the metabolic action of folates we asked ourselves the question: Is the intake of a sufficient amount of this vitamin a benefit or risk for human health? http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Loading next page...
 
/lp/de-gruyter/is-folic-acid-supplementation-to-food-benefit-or-risk-for-human-health-0VBT42yWQr

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
de Gruyter
Copyright
©2013 by Walter de Gruyter Berlin Boston
ISSN
2195-4720
eISSN
2195-4720
DOI
10.1515/pterid-2013-0024
Publisher site
See Article on Publisher Site

Abstract

AbstractThe need for sufficient quantities of folic acid for normal embryogenesis and fetal development is well known. Women of childbearing age must be sure to have an adequate intake of folic acid periconceptionally prior to and during pregnancy. Folate plays an essential role in the biosynthesis of RNA and DNA, phospholipid and neurostransmitters synthesis, using S-adenosylmethionine (SAM) as the primary methyl group donor. In some countries, the knowledge that folic acid is preventable for the reduction of the risk for neural tube defects (NTD) and in lowering the high amount of homocysteine (Hcy) led to the recommendation that all women capable of becoming pregnant should consume 400 µg of folic acid daily. Later, in 1998, folic acid fortification of all enriched cereal grain product flour was implemented in some countries. In addition to careful monitoring of adverse effects, the studies are warranted in order to determine the potentially positive and deleterious effects of folic acid fortification and supplementation on the human health or human diseases. To further understand the metabolic action of folates we asked ourselves the question: Is the intake of a sufficient amount of this vitamin a benefit or risk for human health?

Journal

Pteridinesde Gruyter

Published: Dec 1, 2013

References