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Investigation of the effect of low power laser used in photodynamic therapy for treatment of psoriasis

Investigation of the effect of low power laser used in photodynamic therapy for treatment of... Abstract Objective: The objective of this study was to investigate the effect of power on low-level lasers used in photodynamic therapy (PDT) to treat chronic plaque psoriasis in a group of Sudanese patients. Materials and methods: Twenty-four patients with chronic plaque psoriasis were randomly selected to enter this study from a total of 100 patients who attended the Khartoum Dermatology Teaching Hospital between 2010 and 2011. The lasers used for PDT were three continuous wave diode lasers in the red portion of the electromagnetic spectrum (671–675 nm) with output powers of 16, 50 and 100 mW to activate the chemical photosensitizer (Levulan ® Kerastick ® topical solution), i.e., the 24 patients were divided into three treatment groups (eight patients for each laser power group). Each patient received three sessions at 2-week intervals. The exposure time was 15 min for each laser session. Results: This study showed that 62% of the patients treated with 100 mW achieved complete clearance compared with 25% for those treated with 50 mW and 0% for those treated with 16 mW. Conclusions: The results showed that increasing the power of low-level laser in PDT increased the clearance of plaque psoriasis. PDT can be used as an alternative method for treatment of psoriasis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Photonics & Lasers in Medicine de Gruyter

Investigation of the effect of low power laser used in photodynamic therapy for treatment of psoriasis

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Publisher
de Gruyter
Copyright
Copyright © 2012 by the
ISSN
2193-0635
eISSN
2193-0643
DOI
10.1515/plm-2012-0012
Publisher site
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Abstract

Abstract Objective: The objective of this study was to investigate the effect of power on low-level lasers used in photodynamic therapy (PDT) to treat chronic plaque psoriasis in a group of Sudanese patients. Materials and methods: Twenty-four patients with chronic plaque psoriasis were randomly selected to enter this study from a total of 100 patients who attended the Khartoum Dermatology Teaching Hospital between 2010 and 2011. The lasers used for PDT were three continuous wave diode lasers in the red portion of the electromagnetic spectrum (671–675 nm) with output powers of 16, 50 and 100 mW to activate the chemical photosensitizer (Levulan ® Kerastick ® topical solution), i.e., the 24 patients were divided into three treatment groups (eight patients for each laser power group). Each patient received three sessions at 2-week intervals. The exposure time was 15 min for each laser session. Results: This study showed that 62% of the patients treated with 100 mW achieved complete clearance compared with 25% for those treated with 50 mW and 0% for those treated with 16 mW. Conclusions: The results showed that increasing the power of low-level laser in PDT increased the clearance of plaque psoriasis. PDT can be used as an alternative method for treatment of psoriasis.

Journal

Photonics & Lasers in Medicine – de Gruyter

Published: Nov 1, 2012

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