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Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate physiological barriers

Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate... Abstract In this paper we present a microfluidic system based on transparent biocompatible polymers with a porous membrane as substrate for various cell types which allows the simulation of various physiological barriers under continuous laminar flow conditions at distinct tunable shear rates. Besides live cell and fluorescence microscopy, integrated electrodes enable the investigation of the permeability and barrier function of the cell layer as well as their interaction with external manipulations using the Electric Cell-substrate Impedance Sensing (ECIS) method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Directions in Biomedical Engineering de Gruyter

Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate physiological barriers

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Publisher
de Gruyter
Copyright
Copyright © 2015 by the
ISSN
2364-5504
eISSN
2364-5504
DOI
10.1515/cdbme-2015-0004
Publisher site
See Article on Publisher Site

Abstract

Abstract In this paper we present a microfluidic system based on transparent biocompatible polymers with a porous membrane as substrate for various cell types which allows the simulation of various physiological barriers under continuous laminar flow conditions at distinct tunable shear rates. Besides live cell and fluorescence microscopy, integrated electrodes enable the investigation of the permeability and barrier function of the cell layer as well as their interaction with external manipulations using the Electric Cell-substrate Impedance Sensing (ECIS) method.

Journal

Current Directions in Biomedical Engineering – de Gruyter

Published: Sep 1, 2015

References

  • Electrical impedance of cultured endothelium under fluid flow
  • Micromotion of mammalian cells measured electrically
  • Development of a novel two-channel microfluidic system for biomedical applications in cancer research
  • Investigation of endothelial growth using a polycarbonate based a microfluidic chip as artificial blood capillary vessel with integrated impedance sensors for application in cancer research
  • On-ship epithelial barrier function assays using electrical impedance spectroscopy
  • Investigation of endothelial growth using a polycarbonate based a microfluidic chip as artificial blood capillary vessel with integrated impedance sensors for application in cancer research
  • Development of a novel two-channel microfluidic system for biomedical applications in cancer research
  • A Real-time Electrical Impedance Based Technique to Measure Invasion of Endothelial Cell Monolayer by Cancer Cells
  • Real-Time Impedance Assay to Follow the Invasive Activities of Metastastic Cells in Culture
  • On-ship epithelial barrier function assays using electrical impedance spectroscopy
  • A Real-time Electrical Impedance Based Technique to Measure Invasion of Endothelial Cell Monolayer by Cancer Cells
  • Real-Time Impedance Assay to Follow the Invasive Activities of Metastastic Cells in Culture
  • Electrical impedance of cultured endothelium under fluid flow
  • Micromotion of mammalian cells measured electrically