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Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

Influenza and sudden unexpected death: the possible role of peptide cross-reactivity AbstractThis study investigates the hypothesis that cross-reactions may occur between human cardiac proteins and influenza antigens, thus possibly representing the molecular mechanism underlying influenzaassociated sudden unexpected death (SUD). Using titin protein as a research model, data were obtained on (1) the occurrence of the titin octapeptide AELLVLLE or its mimic AELLVALE in influenza A virus hemagglutinin (HA) sequences; (2) the immunological potential of AELLVLLE and its mimic AELLVALE; (3) the possible role of the flanking amino acid aa) context of the two octapeptide determinants in eliciting cross-reactivity between the human cardiac titin protein and HA antigens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection International de Gruyter

Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

Kanduc, Darja
Infection International , Volume 7 (4): 11 – Dec 30, 2018
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Publisher
de Gruyter
Copyright
© 2019 Darja Kanduc, published by Sciendo
eISSN
2544-0349
DOI
10.2478/ii-2018-0023
Publisher site
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Abstract

AbstractThis study investigates the hypothesis that cross-reactions may occur between human cardiac proteins and influenza antigens, thus possibly representing the molecular mechanism underlying influenzaassociated sudden unexpected death (SUD). Using titin protein as a research model, data were obtained on (1) the occurrence of the titin octapeptide AELLVLLE or its mimic AELLVALE in influenza A virus hemagglutinin (HA) sequences; (2) the immunological potential of AELLVLLE and its mimic AELLVALE; (3) the possible role of the flanking amino acid aa) context of the two octapeptide determinants in eliciting cross-reactivity between the human cardiac titin protein and HA antigens.

Journal

Infection International – de Gruyter

Published: Dec 30, 2018

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