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In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains

In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains ARS Medica Tomitana - 2014; 4(79): 195 - 199 10.1515/arsm-2015-0005 1 2 2 2 Stan Irina , Botnarciuc Mihaela , Tuţă Liliana , Gheorghe Emma In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains Emergency County Clinical Hospital “Sf. Apostol Andrei” Constanţa Faculty of Medicine, University „Ovidius” of Constanţa ABSTRACT lower than resistance to vancomycin (6.76%), but higher Daptomycin is the first antibiotic in a new class of cyclic than the resistance to teicoplanin (2.71%) and linezolid lipopeptides, active in vitro against Gram - positive (1.38%). In our study we did not identify daptomycin cocci. The mechanism of action is a rapid depolarization resistant strains of Enterococcus spp. of the bacterial membrane potential, loss of cytoplasmic In severe infections that require more aggressive contents, mainly K+ ions and inhibition of protein, DNA treatment using active antibiotics on MRSA, daptomycin and RNA synthesis, followed by the bacterial cell death. is a valid therapeutic option, but a susceptibility test is There were investigated 112 strains of Gram-positive required to ensure effective indication. There were no cocci recommended for daptomycin susceptibility daptomycin resistant Enterococcus spp. strains testing. Since the main clinical indications of daptomycin are the severe skin and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png ARS Medica Tomitana de Gruyter

In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains

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Publisher
de Gruyter
Copyright
Sciendo is a De Gruyter company © 2018. ALL RIGHTS RESERVED Powered by PubFactory
ISSN
1841-4036
DOI
10.1515/arsm-2015-0005
Publisher site
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Abstract

ARS Medica Tomitana - 2014; 4(79): 195 - 199 10.1515/arsm-2015-0005 1 2 2 2 Stan Irina , Botnarciuc Mihaela , Tuţă Liliana , Gheorghe Emma In vitro resistance to daptomycin of staphylococcus aureus and enterococcus spp. strains Emergency County Clinical Hospital “Sf. Apostol Andrei” Constanţa Faculty of Medicine, University „Ovidius” of Constanţa ABSTRACT lower than resistance to vancomycin (6.76%), but higher Daptomycin is the first antibiotic in a new class of cyclic than the resistance to teicoplanin (2.71%) and linezolid lipopeptides, active in vitro against Gram - positive (1.38%). In our study we did not identify daptomycin cocci. The mechanism of action is a rapid depolarization resistant strains of Enterococcus spp. of the bacterial membrane potential, loss of cytoplasmic In severe infections that require more aggressive contents, mainly K+ ions and inhibition of protein, DNA treatment using active antibiotics on MRSA, daptomycin and RNA synthesis, followed by the bacterial cell death. is a valid therapeutic option, but a susceptibility test is There were investigated 112 strains of Gram-positive required to ensure effective indication. There were no cocci recommended for daptomycin susceptibility daptomycin resistant Enterococcus spp. strains testing. Since the main clinical indications of daptomycin are the severe skin and

Journal

ARS Medica Tomitanade Gruyter

Published: Nov 1, 2014

Keywords: Medicine; Clinical Medicine; Clinical Medicine, other

References