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In Vitro Degradation Behaviours of PDO Monofilament and Its Intravascular Stents with Braided Structure

In Vitro Degradation Behaviours of PDO Monofilament and Its Intravascular Stents with Braided... Abstract Biodegradable intravascular stent has attracted more and more focus in recent years as an effective solution for angiostenosis. Ideal stents were expected to exhibit sufficient radial force to support the vascular wall, while suitable flexibility for the angioplasty. After vascular remodeling, stents should be degraded into small molecular and be eliminated from human body, causing no potential risk. In this paper, poly-p-dioxanone (PDO) monofilament was braided into net structure with four different braiding density, two of which exhibited sufficient radial force larger than 30 kPa, and three of which showed the bending rigidity within 11.7–88.1 N•mm 2 . The degradation behaviors of monofilaments and stents have been observed for 16 weeks. The findings obtained indicate that degradation first occurred in morphology region, which induced temporary increase of crystallinity, monofilament bending rigidity and stent mechanical properties. During this period, monofilament tends to be hard and brittle and lost its tensile properties. Then the crystalline region was degraded and stent mechanical properties decreased. All the results reveal that the PDO intravascular stents with braided structure were able to afford at least 10 weeks of sufficient support to the vascular wall. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autex Research Journal de Gruyter

In Vitro Degradation Behaviours of PDO Monofilament and Its Intravascular Stents with Braided Structure

Autex Research Journal , Volume 16 (2) – Jun 1, 2016

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Publisher
de Gruyter
Copyright
Copyright © 2016 by the
ISSN
2300-0929
eISSN
2300-0929
DOI
10.1515/aut-2015-0031
Publisher site
See Article on Publisher Site

Abstract

Abstract Biodegradable intravascular stent has attracted more and more focus in recent years as an effective solution for angiostenosis. Ideal stents were expected to exhibit sufficient radial force to support the vascular wall, while suitable flexibility for the angioplasty. After vascular remodeling, stents should be degraded into small molecular and be eliminated from human body, causing no potential risk. In this paper, poly-p-dioxanone (PDO) monofilament was braided into net structure with four different braiding density, two of which exhibited sufficient radial force larger than 30 kPa, and three of which showed the bending rigidity within 11.7–88.1 N•mm 2 . The degradation behaviors of monofilaments and stents have been observed for 16 weeks. The findings obtained indicate that degradation first occurred in morphology region, which induced temporary increase of crystallinity, monofilament bending rigidity and stent mechanical properties. During this period, monofilament tends to be hard and brittle and lost its tensile properties. Then the crystalline region was degraded and stent mechanical properties decreased. All the results reveal that the PDO intravascular stents with braided structure were able to afford at least 10 weeks of sufficient support to the vascular wall.

Journal

Autex Research Journalde Gruyter

Published: Jun 1, 2016

References