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Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology

Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and... Abstract In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png ARS Medica Tomitana de Gruyter

Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology

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Publisher
de Gruyter
Copyright
Copyright © 2012 by the
ISSN
1841-4036
eISSN
1841-4036
DOI
10.2478/v10307-012-0021-y
Publisher site
See Article on Publisher Site

Abstract

Abstract In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications.

Journal

ARS Medica Tomitanade Gruyter

Published: Aug 1, 2012

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