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R. Elin, S. Wolff (1973)
Nonspecificity of the limulus amebocyte lysate test: positive reactions with polynucleotides and proteins.The Journal of infectious diseases, 128 3
(1987)
Pterine : Pig 1 l 1 ente . Col ~ lktoren unci Signalverbind - ungen bei der zelluliiren Interaktion
Selective Induction of MOdonu - clear Phagocytes to Produce Neopterin by IntertCrons
M. Abou-Donia, D. Duch, C. Nichol, O. Viveros (1983)
Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex.Endocrinology, 112 6
(1989)
and Brzoska JE Behandlung der chronischcn Po ! ya l 1 hritis mit IntertCron - gamma
Radioimmunoassay for Determination of Rio - pterin
(1989)
Behandlung der chronischcn Po!ya l1hritis mit IntertCron-gamma
Redl H . Schlag G . and Inth om D . Dery - thro - neopterin pl asma levels in intensive care pa tients with and withou t septic complications
Parallel induction of tctrahy - drohiopterin biosynthesis and indo \ eamine : > . J - dioxygenase activity in human cells and cell lines by interieron - ga 1 l 11 l 1 a
Guzma n RF . Oker - herg CV . Mason AD . and Pruin 11 ' . BA . Effect of Indomethacin o n Resista nce to Endotoxin and Tumour Necrosis Factor Shock
Peroxide and Pteridine : A Hypothesis on the Regulation of Macrophage Antimicrohia l Activity hy Interferon - gamma . In : Gresser I . Vilcek 1 . ( Eds . )
(1992)
a nd Redl H . Die Bedeutung von Media to rcn im traum ati schen Schock
(1986)
Die ha kterielle Peritonitis-cine chirurgische Standorthestimmung
(1987)
Troppmai r 1. Ro kos H. a nd Curti(ls He
Thyroid li 1 l 1 ction and endotoxinemia III experimental peritonitis
. IT . and Simmons RL Mechanisms of the adjuvant elICct of hemoglobin in expcrimental peritonitis . VI . The adjuvant elrect of hemoglobin in granulocytopcnic rats
C. Dinarello (1984)
Interleukin-1 and the pathogenesis of the acute-phase response.The New England journal of medicine, 311 22
D. Duch, S. Bowers, J. Woolf, C. Nichol (1984)
Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species.Life sciences, 35 18
Ein experimcntel \ es Peritonitisll 1 odell an der Ratte - stan - dardisicrte Bcurteilung des Krankheitsverlaules
C. Huber, J. Batchelor, D. Fuchs, A. Hausen, A. Lang, D. Niederwieser, G. Reibnegger, P. Swetly, J. Troppmair, H. Wachter (1984)
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gammaThe Journal of Experimental Medicine, 160
Summary As a result to a microhial stimulus different defence systems are activated. Bacterial lipopolysaccharids (endotoxins) can lead to activation of the immune system in which phagocytic cells like macrophages. secrete cytokines and inflammatory mediators. Owing to a hyperactivation of immune mechanisms and also to generalized inflammatory processes organic lesions or even multiple failure of organs can evolve due to influences by cytokines and anaphylatoxines. On a standardized peritonitis model with wistar-pragrats. release of endotoxin. interferon-gamma synthesis and release of hiopterin into plasma has heen measured 6 hours after intraperi to neal administration of E.-coli-haemoglobin suspension. In the initial phase of the immune response interferon-gamma - being endogenously induced by endotoxin - stimulates synthesis of pteridines. Due to antagonistic effects to the cytokines (which stimulate the inflammatory processes) interferon-gamma regulatorily intervenes with the inflammatory mechanisms. The production of biopterin serves as a measure of activation of the monocyte/macrophage system. In comparison to a control group. treated with sodium chloride. statistically significant different have been found in the measuring parameters endotoxin. biopterin and interferon-gamma. The significant correlation of all parameters confirm the quick activation of immune mechanisms as response of the immune system to endotoxinaemia in diffuse purulent peritonitis.
Pteridines – de Gruyter
Published: Aug 1, 1993
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