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- Publisher
- de Gruyter
- Copyright
- Copyright © 1989 by the
- ISSN
- 0933-4807
- eISSN
- 2195-4720
- DOI
- 10.1515/pteridines.1989.1.4.235
- Publisher site
- See Article on Publisher Site
Abstract
Summary The effects of a diet of 85% casein on the activities of the phenylalanine hydroxylases of rat liver and kidney have been compared. Whereas only the tetrahydrobiopterin-dependent activity of rat hepatic phenylalanine hydroxylase is significantly stimulated, both the tetrahydrobiopterin-dependent and the dimethyltetrahydropterin- dependent activities of the renal enzyme are significantly decreased, after five days of feeding a casein diet. The animals fed a high protein diet for seven days have an increased rate of phenylalanine catabolism in vivo, which is also reflected in increased flux of label from phenylalanine into glucose. The regulation of phenylalanine metabolism, under these conditions, is discussed.
Journal
Pteridines – de Gruyter
Published: Nov 1, 1989