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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity AbstractAutoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown. Starting from reports according to which influenza infection can trigger TTP by the production of ADAMTS13 AAbs, this study explores influenza viruses and ADAMTS13 protein for common peptide sequences that might underlie anti-influenza immune responses able to cross-react with ADAMTS13. Results document that numerous peptides are shared between influenza A and B viruses and ADAMTS13, thus supporting the hypothesis of cross-reactivity as a mechanism driving the generation of anti-ADAMTS13 AAbs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection International de Gruyter

From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

Kanduc, Darja
Infection International , Volume 7 (4): 8 – Dec 30, 2018
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8 pages

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Publisher
de Gruyter
Copyright
© 2019 Darja Kanduc, published by Sciendo
eISSN
2544-0349
DOI
10.2478/ii-2019-0002
Publisher site
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Abstract

AbstractAutoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown. Starting from reports according to which influenza infection can trigger TTP by the production of ADAMTS13 AAbs, this study explores influenza viruses and ADAMTS13 protein for common peptide sequences that might underlie anti-influenza immune responses able to cross-react with ADAMTS13. Results document that numerous peptides are shared between influenza A and B viruses and ADAMTS13, thus supporting the hypothesis of cross-reactivity as a mechanism driving the generation of anti-ADAMTS13 AAbs.

Journal

Infection International – de Gruyter

Published: Dec 30, 2018

References

  • Human parvovirus B19 Clin
  • UniProt Consortium. A fast Peptide Match service for UniProt knowledgebase
  • Before influenza tests results are available