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/lp/de-gruyter/four-different-markers-for-activated-cell-mediated-immunity-compared-wiJVCGCY4p
References (4)
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(1988)
\ ac hter -
(1984)
LAge-S tehr -
D. Burke, R. Redfield, J. Chin (1986)
Classification system for human T-lymphotropic virus type III/lymphadenopathy-associated virus infections.MMWR. Morbidity and mortality weekly report, 35 20
-
(1981)
N . Eng ! . 1
- Publisher
- de Gruyter
- Copyright
- Copyright © 1990 by the
- ISSN
- 0933-4807
- eISSN
- 2195-4720
- DOI
- 10.1515/pteridines.1990.2.1.51
- Publisher site
- See Article on Publisher Site
Abstract
Summary Activated cell-mediated immunity, as defined by four markers, has been studied in HIV-infected patients, and compared with the clinical stages of HIV infection. All the values obtained with such markers (interferon-y expressed on lymphocytes, soluble CD8, soluble IL-2 receptor, and serum neopterin) were observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage IV-C patients. Since the replication of HIV depend strictly on the stimulation of infected cells, T-cell activation in vitro might contribute to a further spread of HIV-1 in infected subjects. Thus permanent or multiple stimulation of the cellular immune system could be an important cofactor in the progression of this syndrome.
Journal
Pteridines – de Gruyter
Published: Jan 1, 1990