Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate

Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of... Summary In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate

Download PDF
5 pages

Loading next page...
 
/lp/de-gruyter/experimental-studies-of-the-effect-of-cyclic-mitoguazone-analogues-on-J6UFajn0Hr

References (6)

Publisher
de Gruyter
Copyright
Copyright © 1998 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pteridines.1998.9.4.217
Publisher site
See Article on Publisher Site

Abstract

Summary In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia.

Journal

Pteridines – de Gruyter

Published: Nov 1, 1998

There are no references for this article.