Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/de-gruyter/distinct-neopterin-excretion-patterns-after-vaccination-kuOfztzgnI
References (4)
-
(1984)
N . Eng ! -
L. Schneck (1975)
Biochemical and Clinical Aspects -
(1988)
Immuno ! -
T. Mosmann, R. Coffman (1987)
Two types of mouse helper T-cell clone Implications for immune regulation.Immunology today, 8 7-8
- Publisher
- de Gruyter
- Copyright
- Copyright © 1990 by the
- ISSN
- 0933-4807
- eISSN
- 2195-4720
- DOI
- 10.1515/pteridines.1990.2.3.147
- Publisher site
- See Article on Publisher Site
Abstract
Summary To compare the involvement of cellular immunity in response to vaccination we have investigated urinary neopterin levels in daily follow-ups of children after vaccination with live measles/mumps vaccine and of adults after boosting with the soluble antigen tetanus toxoid. Neopterin levels distinctly peaked 8 - 11 days after vaccination with measles/mumps vaccine. In contrast, after boosting with soluble antigen tetanus toxoid neopterin levels remained unaffected. Large amounts of neopterin are produced by human monocytes/ macro phages on stimulation with gamma interferon. In patients neopterin concentrations reflect activation of cell mediated immunity. The data imply that distinct pathways of T cell activation are triggered in humans after immunization with live vaccine and with soluble antigen .
Journal
Pteridines – de Gruyter
Published: Sep 1, 1990