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Diffusion Magnetic Resonance Imaging with Applications to Cardiac Muscle: Short Review

Diffusion Magnetic Resonance Imaging with Applications to Cardiac Muscle: Short Review AbstractThis review describes in brief recent magnetic resonance imaging (MRI) methods for assessing cardiac structure in healthy and pathologic state using diffusion-weighted (DW) and diffusion tensor imaging (DTI) approaches. A background on the theory and MR pulse sequences employed in DW/DT imaging is given, along with the calculation of diffusion tensor (D), apparent diffusion coefficient (ADC) and fractional anisotropy (FA). Parametric maps derived from DW/DT images can quantify microstructure alterations due to fibrotic collagen deposition, along with associated changes in cardiac muscle anisotropy. Representative examples of ADC and FA parametric maps are shown from ex vivo high-resolution DT images of explanted healthy and scarred hearts obtained from pre-clinical investigations. Furthermore, examples of fiber tractography demonstrating DTI-based 3D (three-dimensional) reconstruction of fiber directions within the heart are illustrated using advanced open-source software. Lastly, future developments and potential translation of DW/DT methods into routine clinical evaluation for cardiac MR imaging protocols are highlighted. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of West University of Timisoara - Physics de Gruyter

Diffusion Magnetic Resonance Imaging with Applications to Cardiac Muscle: Short Review

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Publisher
de Gruyter
Copyright
© 2020 Mihaela Pop et al., published by Sciendo
ISSN
1224-9718
eISSN
1224-9718
DOI
10.2478/awutp-2020-0007
Publisher site
See Article on Publisher Site

Abstract

AbstractThis review describes in brief recent magnetic resonance imaging (MRI) methods for assessing cardiac structure in healthy and pathologic state using diffusion-weighted (DW) and diffusion tensor imaging (DTI) approaches. A background on the theory and MR pulse sequences employed in DW/DT imaging is given, along with the calculation of diffusion tensor (D), apparent diffusion coefficient (ADC) and fractional anisotropy (FA). Parametric maps derived from DW/DT images can quantify microstructure alterations due to fibrotic collagen deposition, along with associated changes in cardiac muscle anisotropy. Representative examples of ADC and FA parametric maps are shown from ex vivo high-resolution DT images of explanted healthy and scarred hearts obtained from pre-clinical investigations. Furthermore, examples of fiber tractography demonstrating DTI-based 3D (three-dimensional) reconstruction of fiber directions within the heart are illustrated using advanced open-source software. Lastly, future developments and potential translation of DW/DT methods into routine clinical evaluation for cardiac MR imaging protocols are highlighted.

Journal

Annals of West University of Timisoara - Physicsde Gruyter

Published: Dec 1, 2020

Keywords: Cardiac MR imaging; Diffusion-Weighted (DW); Diffusion Tensor (DT); Apparent diffusion coefficient; Fractional Anisotropy; Myocardial fiber directions

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