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Robin ef af.: Immune activation in severe multiple trauma Pteridines Vol. 2,1990, pp. 95-97 Short Communication B. Robin l ), D. Fuchs 2 " W. Koller l ' and H. Wachter 2 ,>, Abteilung fur Anasthesiologie, Universitatsklinik, Anichstr. 35, A-6020 Innsbruck , Austria Institut fLir Medizinische Chemie und Biochemie. Universitat Innsbruck , Fritz-Pregl-Str. 3, A-6020 Innsbruck , Austria I) 2) (Received March 1990) Introduction Severe multiple trauma is defined as an injury which affects more than one body region and the whole pattern of lesions leads to unstability of vital functions . Immune deteriora tion is frequently observed in this group of trauma patients , which usually comprises a decrease in the response to skin testing with recall antigens (1) and decreased proliferative responses to mitogens and alloantigens in \'itro (2). Delayed complications are seen quite o ften in these patients and feature multiple organ failure and 'or sepsis, whi ch contribute to high morbidity and mortality. There is an obvious association bet\veen the altered immunocompetence of patients following traumatic injury of various types and the outcome of patients. The development of sepsis is preferentially seen in patients with diminished in vitro responsiveness of T-cells to stimulation (3).
Pteridines – de Gruyter
Published: May 1, 1990
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